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Pharmacological basis for the role of curcumin in chronic diseases: An age-old spice with modern targets - Source: Trends in Pharmacological Sciences, Feb 2009

  [ 78 votes ]   [ 1 Comment ]
By Bharat B Aggarwal, Bokyung Sung • www.ProHealth.com • February 27, 2009


Curcumin (diferuloylmethane), a yellow pigment in the spice turmeric (also called curry powder), has been used for centuries as a treatment for inflammatory diseases.

Extensive research within the past two decades has shown that curcumin mediates its anti-inflammatory effects through the downregulation of:

• Inflammatory transcription factors (such as nuclear factor kappaB),

• Enzymes (such as cyclooxygenase 2 and 5 lipoxygenase)

• And cytokines (such as tumor necrosis factor, interleukin 1 and interleukin 6).

Because of the crucial role of inflammation in most chronic diseases, the potential of curcumin has been examined in neoplastic [tumorous], neurological, cardiovascular, pulmonary and metabolic diseases.

The pharmacodynamics and pharmacokinetics of curcumin have been examined in animals and in humans.

Various pharmacological aspects of curcumin in vitro [lab] and in vivo [living subjects] are discussed in detail here.

Source: Trends in Pharmacological Sciences, Feb 2009;30(2):85-94. PMID: 19110321 by Aggarwal BB, Sung B. Cytokine Research Laboratory, Department of Experimental Therapeutics, University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA. [E-mail: aggarwal@mdanderson.org]





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Article Comments Post a Comment

Turmeric
Posted by: twylawelty
Mar 5, 2009
My doctor had me add this as a supplement for Fibromyalgia. I use the capsules and I must relate that it has helped relieve the soreness.
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