ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Tea drinkers have lower glaucoma risk

Why Is Chlorella Considered a Superfood?

Soy, cruciferous vegetables could help lower breast cancer treatment side effects

The Long-Term Benefits of Drinking Oolong Tea

Wonderful White Tea: A Drink Fit for an Emperor

Why You Should Try This Sweet-Smelling and Health-Boosting Essential Oil

Arnica: This Powerful Herb Promotes Various Kinds of Healing

Chamomile Tea: Why This Ancient Therapeutic Drink Still Stands Out Today

Get ‘Hooked’ on Cat’s Claw: The Many Benefits of This Amazonian Herb

Try Apple Cider Vinegar and Black Cumin Oil as Your Go-To Salad Dressing

 
Print Page
Email Article

Quercetin increases brain and muscle mitochondrial biogenesis and exercise tolerance – Source: American Journal of Physiology. Regulatory Integrative and Comparative Physiology, Feb 11, 2009

  [ 65 votes ]   [ Discuss This Article ]
By J Mark Davis, PhD, et al. • www.ProHealth.com • March 5, 2009


[Note: Quercetin is a component of green tea and many other colored fruits and vegetables such as red grapes, berries, apples, broccoli & greens.]

Quercetin is one of a broad group of natural polyphenolic flavonoid substances that are being investigated for their widespread health benefits. These benefits have generally been ascribed to its combination of anti-oxidant and anti-inflammatory activity, but recent in vitro [in the lab] evidence suggests that improved mitochondrial biogenesis could play an important role. [Improved development of the cells’ energy-generating mitochondria.]

However, the in vivo [in living subjects] effects of quercetin on mitochondrial biogenesis exercise tolerance are unknown.

We examined the effects of 7 days of quercetin feedings in mice on markers of mitochondrial biogenesis in skeletal muscle and brain, and on endurance exercise tolerance. Mice were randomly assigned to one of three treatment groups: placebo, quercetin 12.5mg/Kg, or quercetin 25mg/Kg.

Following 7 days of treatment mice were sacrificed and soleus muscle and brain were analyzed for mRNA expression of PGC-1alpha and SIRT1, and mtDNA and cytochrome c. Additional mice underwent a treadmill performance run to fatigue or were placed in voluntary activity wheel-cages and their voluntary activity (distance, time & peak speed) was recorded.

Quercetin increased mRNA expression of PGC-1alpha and SIRT1 (P<0.05), mtDNA (P<0.05) and cytochrome c concentration (P<0.05).

These changes in mitochondrial capacity were associated with an increase in both maximal endurance capacity (P<0.05) and voluntary wheel running activity (P<0.05).

These benefits of quercetin on fitness without exercise training:

• May have important implications for enhancement of athletic and military performance

• And may also extend to prevention and/or treatment of chronic diseases.

Source: American Journal of Physiology. Regulatory Integrative and Comparative Physiology, Feb 11, 2009. [Online ahead of print] PMID: 19211721, by Davis JM, Murphy EA, Carmichael MD, Davis B. Department of Exercise Science, Exercise Biochemistry Laboratory, University of South Carolina, Columbia, SC, USA. [E-mail: jmdavis@sc.edu]





Post a Comment

Featured Products From the ProHealth Store
FibroSleep™ Ultra EPA  - Fish Oil Vitamin D3 Extreme™


Article Comments



Be the first to comment on this article!

Post a Comment


 
Optimized Curcumin Longvida with Omega-3

Featured Products

Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength

Natural Remedies

The Fibromyalgia and Glutathione Link The Fibromyalgia and Glutathione Link
Herbal Rescue for High Blood Sugar Herbal Rescue for High Blood Sugar
Complete and Natural Menopause Relief Complete and Natural Menopause Relief
The Fast-Acting Solution for Healthy Digestive Function The Fast-Acting Solution for Healthy Digestive Function
Fighting Fatigue with Ground-breaking French Oak Wood Extract Fighting Fatigue with Ground-breaking French Oak Wood Extract

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2018 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map