ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

10 Fibro-Friendly Foods with a Bonus: Beautiful Skin

Fight Back! Win the War Being Waged Against Your Immune System

Studies Show that Magnesium L-threonate Improves Brain Plasticity, Leading to Direct and Significant...

Clary Sage Oil May Be Pricey, but Its Benefits Are Priceless

Component of red wine, grapes can help to reduce inflammation, study finds

Poly MVA: A Novel Therapy for Increasing Energy, Repairing DNA, and Promoting Overall Health

Pumpkin Pie Turmeric Breakfast Smoothie - Vegan + Gluten-Free

Vitamin D supplementation extends life in mouse model of Huntington's disease

What’s Fenugreek Good For?

Omega-3 fatty acid stops known trigger of lupus

Print Page
Email Article

Chilies Help Researchers Find Mechanism of Arthritis Inflammation & Pain

  [ 48 votes ]   [ Discuss This Article ] • October 2, 2002

Scientists at Massachusetts General Hospital (MGH) have discovered a common component to the burning sensation produced by chili peppers and the pain associated with arthritis. The finding, published in the September 26 issue of Neuron, could help scientists devise new strategies to block the pain hypersensitivity associated with inflammation.

"The receptor activated by chili peppers in the mouth and other tissues also increases in the terminals of sensory neurons in the skin after inflammation, and this contributes to pain hypersensitivity," says Clifford Woolf, M.D., Ph.D., director of the Neural Plasticity Research Group in the Department of Anesthesia and Critical Care at MGH. A receptor is a protein that transports a chemical signal into a cell.

Woolf and lead author Ru-Rong Ji, Ph.D., also of the MGH Neural Plasticity Research Group, found that the increased production of the receptor following inflammation is controlled by a signal molecule called p38, located within sensory neurons. The chili pepper receptor, which is technically called TRPV1, responds to capsaicin, the chemical that is responsible for the "hot" in peppers. It also responds to actual heat and to low pH, a condition that occurs with inflammation.

"With these findings, we're starting to understand why patients with arthritis or other inflammatory conditions are likely to have increased pain and sensitivity to heat," says Woolf. He and his research team were surprised to find that the activation of p38 can cause a twenty-fold increase in the amount of TRPV1 protein in the skin but not in the activity of the gene coding for TRPV1.

"This means that the chili pepper receptor is not being regulated by the gene being switched on but by more protein being produced, an unexpected form of regulation," says Ji. He also notes that their findings will open up new options for pain management. "We could use an inhibitor to p38 to block the increase in TRPV1, therefore blocking pain in patients who suffer from many diseases and conditions that involve inflammation."

Following inflammation, the activation of p38 is very precise. The scientists found that it is caused by a specific growth factor signal acting on a particular subset of pain sensory neurons. There are a variety of pain sensations that create different changes within neurons, and all of the signals that are generated have not yet been identified. Each new discovery, like the current finding by the MGH researchers, sheds light on these complex pathways and brings new treatment strategies closer.

Post a Comment

Featured Products From the ProHealth Store
Ultra EPA  - Fish Oil Ultra ATP+, Double Strength Mitochondria Ignite™ with NT Factor®

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products

Article Comments

Be the first to comment on this article!

Post a Comment

Natural Pain Relief Supplements

Featured Products

Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%

Natural Remedies

Physically and Mentally Exhausted? How to Restore Energy at Its Source Physically and Mentally Exhausted? How to Restore Energy at Its Source
Block food Cravings At Their Molecular Root Block food Cravings At Their Molecular Root
Anti-Inflammatory Properties of Tart Cherry Anti-Inflammatory Properties of Tart Cherry
The Brain Boosting and Fatigue Fighting B-12 The Brain Boosting and Fatigue Fighting B-12
Nutrients to Combat the Modern Stress Epidemic Nutrients to Combat the Modern Stress Epidemic

ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
Credit Card Processing
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map