ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Astaxanthin Is a Longevity Promoter

Meta-analysis links vitamin D deficiency with increased risk of mortality during 10.5 year median pe...

Prevent Or Reverse Diabetes: An Amazing Herbal Intervention

Exercise and Vitamin D Better Together for Heart Health

VIDEO: Essential Oils for Weight Loss

Can Valerian Root Help You Sleep Better?

Eight servings of veggies a day is clearly best for the heart

The Many Wonders of Calming Sandalwood Oil

Can Ginkgo Give Your Brain a Boost?

Fighting Statin-Induced Diabetes with CoQ10

 
Print Page
Email Article

Chilies Help Researchers Find Mechanism of Arthritis Inflammation & Pain

  [ 48 votes ]   [ Discuss This Article ]
www.ProHealth.com • October 2, 2002


Scientists at Massachusetts General Hospital (MGH) have discovered a common component to the burning sensation produced by chili peppers and the pain associated with arthritis. The finding, published in the September 26 issue of Neuron, could help scientists devise new strategies to block the pain hypersensitivity associated with inflammation.

"The receptor activated by chili peppers in the mouth and other tissues also increases in the terminals of sensory neurons in the skin after inflammation, and this contributes to pain hypersensitivity," says Clifford Woolf, M.D., Ph.D., director of the Neural Plasticity Research Group in the Department of Anesthesia and Critical Care at MGH. A receptor is a protein that transports a chemical signal into a cell.

Woolf and lead author Ru-Rong Ji, Ph.D., also of the MGH Neural Plasticity Research Group, found that the increased production of the receptor following inflammation is controlled by a signal molecule called p38, located within sensory neurons. The chili pepper receptor, which is technically called TRPV1, responds to capsaicin, the chemical that is responsible for the "hot" in peppers. It also responds to actual heat and to low pH, a condition that occurs with inflammation.

"With these findings, we're starting to understand why patients with arthritis or other inflammatory conditions are likely to have increased pain and sensitivity to heat," says Woolf. He and his research team were surprised to find that the activation of p38 can cause a twenty-fold increase in the amount of TRPV1 protein in the skin but not in the activity of the gene coding for TRPV1.

"This means that the chili pepper receptor is not being regulated by the gene being switched on but by more protein being produced, an unexpected form of regulation," says Ji. He also notes that their findings will open up new options for pain management. "We could use an inhibitor to p38 to block the increase in TRPV1, therefore blocking pain in patients who suffer from many diseases and conditions that involve inflammation."

Following inflammation, the activation of p38 is very precise. The scientists found that it is caused by a specific growth factor signal acting on a particular subset of pain sensory neurons. There are a variety of pain sensations that create different changes within neurons, and all of the signals that are generated have not yet been identified. Each new discovery, like the current finding by the MGH researchers, sheds light on these complex pathways and brings new treatment strategies closer.






Post a Comment

Featured Products From the ProHealth Store
Vitamin D3 Extreme™ FibroSleep™ Energy NADH™ 12.5mg

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function

Natural Remedies

Fight Inflammation and Promote Cognitive Health with High-OPC Grape Seed Fight Inflammation and Promote Cognitive Health with High-OPC Grape Seed
Three-Step Strategy to Reverse Mitochondrial Aging Three-Step Strategy to Reverse Mitochondrial Aging
Irritable Bowel Syndrome: Unlocking the Secrets of Peppermint, Acacia and Fennel Irritable Bowel Syndrome: Unlocking the Secrets of Peppermint, Acacia and Fennel
Vitamin K-2 – A Key Player in Cardiovascular and Bone Health Vitamin K-2 – A Key Player in Cardiovascular and Bone Health
Pioneer Scientists Uncover a Revolutionary Neuroprotective Supplement for Nerve Health Pioneer Scientists Uncover a Revolutionary Neuroprotective Supplement for Nerve Health

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map