ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Can Autoimmune Conditions be Reversed? Researchers Make a Surprising Discovery

How One Tiny Molecule Turned into One Huge Health Breakthrough

Nutrients Boost Stem Cell Function

Humans have three times more brown body fat

B12 Proven Essential for Every Cell

Soy isoflavones may benefit breast cancer patients

How B Vitamins Improve Brain Health, Cognition, Psychiatric Problems and Mood Disorders

Dietary prebiotics improve sleep, buffer impacts of stress, says study

Ylang Ylang Oil Not Only Soothes Your Skin, but Your Mind as Well

Exercises to Help Prevent Urinary Incontinence

 
Print Page
Email Article

High-Dose B Vitamin Supplementation and Progression of Subclinical Atherosclerosis: A Randomized Controlled Trial – Source: Stroke, Mar 1, 2009

  [ 15 votes ]   [ Discuss This Article ]
By Howard N. Hodis, MD, et al. • www.ProHealth.com • March 13, 2009


[Note: to read the full text of this article free, click here]

Background and Purpose: Although plasma total homocysteine (tHcy) levels are associated with cardiovascular disease, it remains unclear whether homocysteine is a cause or a marker of atherosclerotic vascular disease. We determined whether reduction of total homocysteine levels with B vitamin supplementation reduces subclinical atherosclerosis progression.

Methods: In this double-blind clinical trial, 506 participants 40 to 89 years of age with an initial total homocysteine greater than 8.5 µmol/L without diabetes and cardiovascular disease were randomized to:

• High-dose B vitamin supplementation (5 mg folic acid [B9] plus 0.4 mg vitamin B12 plus 50 mg vitamin B6 )

• Or matching placebo… for 3.1 years.

Subclinical atherosclerosis progression across 3 vascular beds was assessed using high-resolution B-mode ultrasonography to measure:

• Carotid artery intima media thickness (primary outcome) [Thickness of walls in artery supplying blood to the head and neck – strongly associated with plaque buildup/loss of flexibility.]

• And multidetector spiral CT to measure aortic and coronary artery calcium (secondary outcome).

Results: Although the overall carotid artery intima media thickness progression rate was lower with B vitamin supplementation than with placebo, statistically significant between-group differences were not found (P=0.31).

However:

• Among subjects with baseline total homocysteine of 9.1 µmol/L or greater, those randomized to B vitamin supplementation had a statistically significant lower average rate of carotid artery intima media thickness progression compared with placebo (P=0.02);

• Among subjects with a baseline tHcy less than 9.1 µmol/L, there was no significant treatment effect (probability value for treatment interaction=0.02).

B vitamin supplementation had no effect on progression of aortic or coronary artery calcification overall or within subgroups.

Conclusion:

High-dose B vitamin supplementation significantly reduces progression of early-stage subclinical atherosclerosis (carotid artery intima media thickness) in well-nourished healthy B vitamin "replete" individuals at low risk for cardiovascular disease with a fasting total homocysteine of 9.1 µmol/L or greater.

Source: Stroke, Mar 1, 2009;40:730. Hodis WJ, Dustin L, Mahrer PR, Azen SP, Detrano R, Selhub J, Alaupovic P, Liu C, Liu C, Hwang J, Wilcox AG, Selzer RH. University of Southern California, Keck School of Medicine; University of Southern California, School of Pharmacy; Kaiser Permanente Medical Center, Los Angeles; Harbor–University of California at Los Angeles Medical Center, California; USDA Human Nutrition Research Center on Aging and Department of Vitamin Metabolism and Aging, Tufts University, Boston, Massachusetts; Oklahoma Medical Research Foundation, Oklahoma City; Jet Propulsion Laboratory, California Institute of Technology, Pasadena, California. [E-mail: Howard N. Hodis, MD athero@usc.edu]





Post a Comment

Featured Products From the ProHealth Store
Energy NADH™ 12.5mg Vitamin D3 Extreme™ Mitochondria Ignite™ with NT Factor®

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%

Natural Remedies

Health Benefits Are Brewing in Green Tea Health Benefits Are Brewing in Green Tea
Running on Empty? Fuel Up with NADH Running on Empty? Fuel Up with NADH
Block Acid Reflux to Prevent Esophageal Problems! Block Acid Reflux to Prevent Esophageal Problems!
Reversing Neurodegeneration with a New Magnesium Compound Reversing Neurodegeneration with a New Magnesium Compound
Could a B-12 Deficiency Be Causing Your Symptoms? Could a B-12 Deficiency Be Causing Your Symptoms?

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map