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Altered amino acid homeostasis in subjects affected by Fibromyalgia - Source: Clinical Biochemistry, Mar 9, 2009

  [ 6 votes ]   [ 2 Comments ]
By Laura Bazzichi, et al. • www.ProHealth.com • March 14, 2009


[Note: Amino acids are building blocks of the proteins responsible for virtually all metabolic activities in living cells. The body can produce 10 of these acids, but the other 10 (“essential” amino acids) must be supplied via protein in the diet or supplements. These can’t be stored, and failure to obtain even 1 of the essential 10 every day results in degradation of the body’s muscle & other proteins.]

Objectives: To evaluate plasma amino acids (AA) concentrations in patients affected by fibromyalgia (FM) and to study the relationships between their levels and FM clinical parameters.

Design and Methods: 20 amino acids were assessed in 34 FM patients and in 18 healthy volunteers by means of a modified version of the Waters picotag method.

Results: Significant lower plasma
• Taurine,
• Alanine,
• Tyrosine (Tyr),
• Valine,
• Methionine,
• Phenylalanine,
• Threonine concentrations
• And sum of essential amino acids were observed in FM patients vs. healthy controls (P<0.05).

Tyrosine CAAs [competing amino acids] ratio and the sum of amino acids competing with tryptophan for brain uptake resulted significantly reduced in FM (p<0.05).

Significant correlations were found between FM clinical parameters and certain amino acids.

Conclusion:

• Our results suggest a probable defects of gut malabsorption of certain amino acids in FM patients.

• Moreover, given the reduced Tyr CAAs ratio in FM patients, a possible impairment of catecholaminergic system in the FM syndrome may be suggested. [Catecholamines are substances derived from the amino acid tyrosine and produced in the medulla of the adrenal gland that act as neurotransmitters or hormones, such as dopamine and adrenaline.]

Source: Clinical Biochemistry, Mar 9, 2009. PMID: 19281806, by Bazzichi L, Palego L, Giannaccini G, Rossi A, De Feo F, Giacomelli C, Betti L, Giusti L, Bombardieri S, Lucacchini A. Department of Internal Medicine, Division of Rheumatology, University of Pisa, Pisa, Italy. [E-mail: l.bazzichi@int.med.unipi.it]





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Article Comments Post a Comment

RE:supplement
Posted by: limbo
Mar 15, 2009
Would you recommend a supplement of all amino acids or just the listed? Would we absorb them or is this a defect in fibromyalgia patients untreatable. I came upon this with interest as I feel this is what my instinct is directing me to.
Reply Reply

AMINO ACIDS
Posted by: Shirleend
Mar 17, 2009
Having been misdiagnosed with Fibromyalgia, I now know that I have a metabolic disorder that is specifically a problem with the process amino acids go through. Please, please take this study as a strong indication that if you have been diagnosed with Fibromyalgia/chronic fatigue, please get a plasma amino acid panel done before you take any supplements. Email me for any questions, Shirleen_D@hotmail.com
Reply Reply
 
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