[Note: the Framingham study is an open-ended multi-generational project that has been tracking the health, dietary and other habits of residents of Framingham, Massachusetts for 60 years.]
Summary: Vitamin C may play a role in bone health. In the Framingham Study, subjects with higher total or supplemental vitamin C intake had fewer hip fractures and non-vertebral fractures as compared to subjects with lower intakes. Therefore, vitamin C may have a protective effect on bone health in older adults.
Introduction: Dietary antioxidants such as vitamin C may play a role in bone health. We evaluated associations of vitamin C intake (total, dietary, and supplemental) with incident hip fracture and non-vertebral osteoporotic fracture, over a 15- to 17-year follow-up, in the Framingham Osteoporosis Study.
Methods: 366 men and 592 women (mean age 75 +/- 5 years) completed a food frequency questionnaire (FFQ) in 1988-1989 and were followed for non-vertebral fracture until 2003 and hip fracture until 2005.
Tertiles of vitamin C intake were created from estimates obtained using the Willett FFQ, after adjusting for total energy (residual method). Hazard ratios were estimated using Cox-proportional hazards regression, adjusting for covariates.
Results: Over follow-up 100 hip fractures occurred.
• Subjects in the highest tertile of total vitamin C intake had significantly fewer hip fractures (P trend = 0.04) and non-vertebral fractures (P trend = 0.05) compared to subjects in the lowest tertile of intake.
• Subjects in the highest category of supplemental vitamin C intake had significantly fewer hip fractures (P trend = 0.02) and non-vertebral fractures (P trend = 0.07) compared to non-supplement users.
• Dietary vitamin C intake was not associated with fracture risk (all P > 0.22).
Conclusion: These results suggest a possible protective effect of vitamin C on bone health in older adults.
Source: Osteoporosis International, Apr 4, 2009. PMID: 19347239, by Sahni S, Hannan MT, Gagnon D, Blumberg J, Cupples LA, Kiel DP, Tucker KL. Dietary Assessment and Epidemiology Research Program, Jean Mayer USDA Human Nutrition Research Center on Aging; Friedman School of Nutrition Science and Policy, Tufts University, Boston, Massachusetts, USA. [E-mail: Katherine.firstname.lastname@example.org]