ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Vitamin D supplements, sleep could help manage pain

Bacopa: The Herb That May Increase Your Brain Power

Lilac Oil: More Than Just for Fragrance

Eat More Yogurt and Avoid Osteoporosis

Safflower: An Economically Important Herb That Can Benefit Humans and Animals Alike

What Is Bilberry Good For?

Coffee, herbal tea may help prevent liver fibrosis

Crafty Uses for Carrot Seed Oil

Resveratrol Improves Arteries

Higher omega 3 levels linked to improved brain blood flow

Print Page
Email Article

145-Center Trials of New Pain Med for Knee & Hip Osteoarthritis Recruiting

  [ 7 votes ]   [ Discuss This Article ] • April 27, 2009

Two trials - Tanezumab in Osteoarthritis of the Knee (at 66 clinical centers), and Tanezumab in Osteoarthritis of the Hip (79 centers) - are now recruiting across the U.S.

The Phase 3 placebo-controlled trials will measure ability of the monoclonal antibody drug tanezumab to improve pain, stiffness, and physical function. Therapy will involve IV administration every 8 weeks for 32 weeks – in four trial arms involving 3 different dosages and a placebo group.

WHO MAY BE ELIGIBLE: The trial sites are recruiting patients 18 years and older, ACR diagnosed with osteoarthritis of the knee or hip and:
• Unwilling or unable to take non-opiate pain meds such as NSAIDS
• Or for whom non-opiate meds have not provided adequate pain relief
• Or who are candidates for hip/knee injections, arthroplasty, or replacement surgery.
• Willing to discontinue pain meds before & during study (excepting acetaminophen up to certain level)

A monoclonal antibody is a laboratory-produced substance that can bind to specific protein molecules – in this case to nerve growth factor which arises at sites of inflammation and is thought to worsen pain. (For example, tanezumab has been shown in a previous study of patients with knee osteoarthritis who hadn’t been helped by NSAIDS to improve knee pain, physical function & stiffness significantly.)

NSAIDS - nonsteroidal anti-inflammatory drugs - such as aspirin, ibuprofen, and naproxin (e.g., Aleve) work by inhibiting cyclooxygenase (COX), an enzyme that encourages inflammation. They all involve some risk, ranging from aspirin’s potential effects on the stomach lining to blood pressure, heart, and kidney problems. NSAIDS reportedly reduce inflammation in about 60% of patients, and about 10% don’t benefit from any NSAID.

About these trials, including inclusion/exclusion criteria and the trial site listings, and to contact a trial site near you, go to the pages for:

Tanezumab in Osteoarthritis of the Knee

Tanezumab in Osteoarthritis of the Hip.

NOTE: A THIRD TRIAL, not yet recruiting and targeting 800 participants - Tanezumab in Osteoarthritis of the Knee(2) - will test tanezumab by comparison with the NSAID naproxen. For information about this trial, go to

Post a Comment

Featured Products From the ProHealth Store
FibroSleep™ Optimized Curcumin Longvida® Mitochondria Ignite™ with NT Factor®

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products

Article Comments

Be the first to comment on this article!

Post a Comment

NAD+ Ignite with Niagen

Featured Products

Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function

Natural Remedies

Priming Your Immune System for Cold & Flu Season Priming Your Immune System for Cold & Flu Season
Rejuvenating the Brain - How PQQ Helps Power Up Mental Processing Rejuvenating the Brain - How PQQ Helps Power Up Mental Processing
Green Coffee Extract: Unique Obesity Intervention Green Coffee Extract: Unique Obesity Intervention
The Remarkable Benefits of Reishi Medicinal Mushrooms The Remarkable Benefits of Reishi Medicinal Mushrooms
Health Benefits Are Brewing in Green Tea Health Benefits Are Brewing in Green Tea

ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
Credit Card Processing
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map