ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Friendly User's Guide for the Timing of Nutritional Supplements

The Health Benefits of Manuka Honey

Increase Your Magnesium Intake

Vitamin D supplementation could ease IBS symptoms

Top Tips to Boost Your Immunity

11 Amazing Health Benefits of Using Baking Soda

Nicotinamide riboside shows promise for treatment of Alzheimer’s disease

Exercise, calcium, vitamin D, and other factors linked with fewer injurious falls

Mediterranean diet associated with lower risk of aggressive prostate cancer

Vitamin D3 Is a Powerhouse for Your Heart

 
Print Page
Email Article

145-Center Trials of New Pain Med for Knee & Hip Osteoarthritis Recruiting

  [ 7 votes ]   [ Discuss This Article ]
www.ProHealth.com • April 27, 2009


Two trials - Tanezumab in Osteoarthritis of the Knee (at 66 clinical centers), and Tanezumab in Osteoarthritis of the Hip (79 centers) - are now recruiting across the U.S.

The Phase 3 placebo-controlled trials will measure ability of the monoclonal antibody drug tanezumab to improve pain, stiffness, and physical function. Therapy will involve IV administration every 8 weeks for 32 weeks – in four trial arms involving 3 different dosages and a placebo group.

WHO MAY BE ELIGIBLE: The trial sites are recruiting patients 18 years and older, ACR diagnosed with osteoarthritis of the knee or hip and:
• Unwilling or unable to take non-opiate pain meds such as NSAIDS
• Or for whom non-opiate meds have not provided adequate pain relief
• Or who are candidates for hip/knee injections, arthroplasty, or replacement surgery.
• Willing to discontinue pain meds before & during study (excepting acetaminophen up to certain level)

WHAT IS A MONOCLONAL ANTIBODY/TANEZUMAB?
A monoclonal antibody is a laboratory-produced substance that can bind to specific protein molecules – in this case to nerve growth factor which arises at sites of inflammation and is thought to worsen pain. (For example, tanezumab has been shown in a previous study of patients with knee osteoarthritis who hadn’t been helped by NSAIDS to improve knee pain, physical function & stiffness significantly.)

WHY AN ALTERNATIVE TO NSAIDS?
NSAIDS - nonsteroidal anti-inflammatory drugs - such as aspirin, ibuprofen, and naproxin (e.g., Aleve) work by inhibiting cyclooxygenase (COX), an enzyme that encourages inflammation. They all involve some risk, ranging from aspirin’s potential effects on the stomach lining to blood pressure, heart, and kidney problems. NSAIDS reportedly reduce inflammation in about 60% of patients, and about 10% don’t benefit from any NSAID.

TO LEARN MORE
About these trials, including inclusion/exclusion criteria and the trial site listings, and to contact a trial site near you, go to the ClinicalTrials.gov pages for:

Tanezumab in Osteoarthritis of the Knee

Tanezumab in Osteoarthritis of the Hip.

NOTE: A THIRD TRIAL, not yet recruiting and targeting 800 participants - Tanezumab in Osteoarthritis of the Knee(2) - will test tanezumab by comparison with the NSAID naproxen. For information about this trial, go to www.clinicaltrials.gov/ct2/show/NCT00830063




Post a Comment

Featured Products From the ProHealth Store
Optimized Curcumin Longvida® Vitamin D3 Extreme™ Mitochondria Ignite™ with NT Factor®


Article Comments



Be the first to comment on this article!

Post a Comment


 
Optimized Curcumin Longvida with Omega-3

Featured Products

Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get Energized with Malic Acid & Magnesium
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength

Natural Remedies

Live Without Anxiety or Stress Live Without Anxiety or Stress
Curcumin - a Golden Gift of Nature with Benefits Still Untold Curcumin - a Golden Gift of Nature with Benefits Still Untold
Secret Nutrient for Radiant Skin Secret Nutrient for Radiant Skin
Magnesium + Malic Acid: One-Two Punch for Pain & Fatigue Magnesium + Malic Acid: One-Two Punch for Pain & Fatigue
Natural Relief for Soreness, Pain and Swelling - Putting Out the Fire Natural Relief for Soreness, Pain and Swelling - Putting Out the Fire

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2018 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map