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Mapping brain response to pain in fibromyalgia patients using temporal analysis of fMRI – Source: PLoS ONE, Apr 21, 2009

  [ 5 votes ]   [ Discuss This Article ]
By J Pujol, et al. • • April 29, 2009

[Note: This is an open access article. The full text is available in PDF for free at]

Background: Nociceptive stimuli may evoke brain responses longer than the stimulus duration often partially detected by conventional neuroimaging. Fibromyalgia patients typically complain of severe pain from gentle stimuli. We aimed to characterize brain response to painful pressure in fibromyalgia patients by generating activation maps adjusted for the duration of brain responses.

Methodology/Principal Findings: Twenty-seven women (mean age: 47.8 years) were assessed with fMRI. The sample included nine fibromyalgia patients and nine healthy subjects who received 4 kg/cm(2) of pressure on the thumb. Nine additional control subjects received 6.8 kg/cm(2) to match the patients for the severity of perceived pain. Independent Component Analysis characterized the temporal dynamics of the actual brain response to pressure. Statistical parametric maps were estimated using the obtained time courses.

• Brain response to pressure (18 seconds) consistently exceeded the stimulus application (9 seconds) in somatosensory regions in all groups.

• fMRI maps following such temporal dynamics showed a complete pain network response (sensory-motor cortices, operculo-insula, cingulate cortex, and basal ganglia) to 4 kg/cm(2) of pressure in fibromyalgia patients.

• In healthy subjects, response to this low intensity pressure involved mainly somatosensory cortices.

• When matched for perceived pain (6.8 kg/cm(2)), control subjects showed also comprehensive activation of pain-related regions,

• But fibromyalgia patients showed significantly larger activation in the anterior insula-basal ganglia complex and the cingulate cortex.

Conclusions/Significance: The results suggest that data-driven fMRI assessments may complement conventional neuroimaging for characterizing pain responses and that enhancement of brain activation in fibromyalgia patients may be particularly relevant in emotion-related regions.

Source: PLoS ONE, Apr 21, 2009;4(4):e5224. PMID: 19381292, by Pujol J, López-Solà M, Ortiz H, Vilanova JC, Harrison BJ, Yücel M, Soriano-Mas C, Cardoner N, Deus J. Institut d'Alta Tecnologia-PRBB, CRC Corporacio Sanitaria, Barcelona, Spain. [E-mail:]

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