Background: Membranous dysmenorrhea is a rare entity involving expulsion of fragments of endometrium retaining the shape of the uterus. The condition is often linked to high progesterone levels. [Progesterone is a female hormone produced by the ovaries.] An association with a chronic fatigue syndrome was never described.
Case: A 44-year-old woman with a chronic fatigue syndrome (CFS), presented with membranous dysmenorrhea after taking an oral contraceptive pill containing ethinylestradiol 0.02 mg and desogestrel 0.15 mg [an estrogen compound and a progesterone-like compound] for 3 months in a continuous regimen as treatment for dysfunctional bleeding. Oral contraception was discontinued and she resumed normal menstruations. Remarkably, she mentioned complete disappearance of the CFS since expulsion of the tissue and started working again.
Conclusion: The occurrence of membranous dysmenorrhea with a dissolving chronic fatigue syndrome is very rare and was never described before. This case suggests a hormonal dysfunction as a possible cause of chronic fatigue syndrome. A review of the literature on membranous dysmenorrhea is presented.
Source: Archives of Gynecology and Obstretrics, May 2009. 279(5):717-20. PMID: 18787800, by Veldman J, Van Houdenhove B, Verguts J. Department of Obstetrics and Gynaecology, University Hospital Gasthuisberg, Catholic University Leuven, Louvain, Belgium. [Email: firstname.lastname@example.org]