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Serum and Dietary Magnesium and Risk of Ischemic Stroke: The Atherosclerosis Risk in Communities Study – Source: American Journal of Epidemiology, Apr 16, 2009

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By Ohira Tetsuya, Aaron R Folsom, et al. • www.ProHealth.com • May 19, 2009


The authors sought to examine the relation between serum or dietary magnesium and the incidence of ischemic stroke among blacks and whites.

Between 1987 and 1989, 14,221 men and women aged 45–64 years took part in the first examination of the Atherosclerosis Risk in Communities Study cohort. The incidence of stroke was ascertained from hospital records.

Higher serum magnesium levels were associated with lower prevalence of hypertension and diabetes mellitus at baseline.

During the 15-year follow-up, 577 ischemic strokes occurred.

Serum magnesium was inversely associated with ischemic stroke incidence [higher magnesium, lower stroke incidence].

The age-, sex-, and race-adjusted rate ratios of ischemic stroke for those with serum magnesium levels of 1.5, 1.6, 1.7 or less, and 1.8 or more mEq/L were 1.0, 0.78 (95% confidence interval (CI): 0.62, 0.96), 0.70 (95% CI: 0.56, 0.88), and 0.75 (95% CI: 0.59, 0.95) (Ptrend = 0.005). [A ratio of 1.0 would indicate no difference in incidence. The ratio of 0.75, for example, would indicate a 25% reduced stroke incidence for those whose serum magnesium was 1.8 mEq/L or more.] After adjustment for hypertension and diabetes, the rate ratios were attenuated to nonsignificant levels.

• Dietary magnesium intake was marginally inversely associated with the incidence of ischemic stroke (Ptrend = 0.09).

• Low serum magnesium levels could be associated with increased risk of ischemic stroke, in part, via effects on hypertension and diabetes.

Source: American Journal of Epidemiology, Apr 16, 2009 PMID xxxx, by Ohira T, Peacock JM, Iso H, Chambless LE, Rosamond WD, Folsom AR. Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA. [E-mail: folso001@umn.edu]





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