ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

How Can You Benefit From Vitamin B12?

Discover Why Ashwagandha Can Be Used for Stress and Anxiety

Calorie restriction promotes longevity through effects on mitochondrial network

Higher resveratrol dose linked to lower glucose levels in type 2 diabetics

Tryptophan's Possible Effects for Your Health

What Is Bitter Orange?

Black Tea Is Great for Your Gut

Ashwagandha Helps Hormones - Aids Arthritis

Drug can dramatically reduce weight of people with obesity

New Finding: Broccoli Helps Heal Leaky Gut

 
Print Page
Email Article

Sulfide, the first inorganic substrate for human cells – Source: The FASEB Journal, Jun 2007

  [ 5 votes ]   [ Discuss This Article ]
By Marc Goubern, Frederic Bouillaud, et al. • www.ProHealth.com • June 8, 2009


[Note: The full text of this article is available free at www.fasebj.org/cgi/content/abstract/21/8/1699]

Hydrogen sulfide (H2S) is produced inside the intestine and is known as a poison that inhibits cellular respiration at the level of cytochrome oxidase.

However, sulfide is used as an energetic substrate by many photo- and chemoautotrophic bacteria and by animals such as the lugworm Arenicola marina

The concentrations of sulfide present in their habitats are comparable with those present in the human colon.

Using permeabilized colonic cells to which sulfide was added by an infusion pump we show that the maximal respiratory rate of colonocyte mitochondria in presence of sulfide compares with that obtained with succinate or L-alpha-glycerophosphate. This oxidation is accompanied by mitochondrial energization.

In contrast, other cell types not naturally exposed to high concentration of sulfide showed much lower oxidation rates.

Mitochondria showed a very high affinity for sulfide that permits its use as an energetic substrate at low micromolar concentrations, hence, below the toxic level.

However, if the supply of sulfide exceeds the oxidation rate, poisoning renders mitochondria inefficient and our data suggest that an anaerobic mechanism involving partial reversion of Krebs cycle already known in invertebrates takes place. [The Krebs cycle is a complex series of chemical reactions involved in cellular energy production.]

In conclusion, this work provides additional and compelling evidence that sulfide is not only a toxic compound. According to our study, sulfide appears to be the first inorganic substrate for mammalian cells characterized thus far.

Source: The FASEB Journal, Jun 2007;21(8):1699-706. PMID: 17314140, by Goubern M, Andriamihaja M, Nübel T, Blachier F, Bouillaud F. Ecole Pratique des Hautes Etudes and Nurelice, Jouy en Josas; Universite Rene Descartes, Paris, France. [E-mail: bouillaud@necker.fr]





Post a Comment

Featured Products From the ProHealth Store
Vitamin D3 Extreme™ Ultra EPA  - Fish Oil Ultra ATP+, Double Strength


Article Comments



Be the first to comment on this article!

Post a Comment


 
Optimized Curcumin Longvida with Omega-3

Featured Products

FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function

Natural Remedies

Are You Obtaining the Proper Enzymes? Are You Obtaining the Proper Enzymes?
How to Jump-start and Sustain Energy Production in CFS How to Jump-start and Sustain Energy Production in CFS
Running on Empty? Fuel Up with NADH Running on Empty? Fuel Up with NADH
More Weight Loss than Any Other Discovery in Supplement History More Weight Loss than Any Other Discovery in Supplement History
Fighting Fatigue with Ground-breaking French Oak Wood Extract Fighting Fatigue with Ground-breaking French Oak Wood Extract

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map