ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Can Autoimmune Conditions be Reversed? Researchers Make a Surprising Discovery

Scientifically-designed fasting diet lowers risks for major diseases

How One Tiny Molecule Turned into One Huge Health Breakthrough

Acupuncture boosts effectiveness of standard medical care for chronic pain, depression

Research on Astaxanthin Demonstrates Significant Whole Body Benefits

Humans have three times more brown body fat

Nutrients Boost Stem Cell Function

B12 Proven Essential for Every Cell

Soy isoflavones may benefit breast cancer patients

Dietary prebiotics improve sleep, buffer impacts of stress, says study

 
Print Page
Email Article

DNIC’s efficacy across [the] menstrual cycle in women with fibromyalgia – Source: American Pain Society Annual Scientific Conference, May 2009

  [ 24 votes ]   [ Discuss This Article ]
By E Paul-Savoie, et al. • www.ProHealth.com • June 13, 2009


[Note: DNIC – diffuse noxious inhibitory controls – is a pain inhibition response originating at the spinal cord level when pain stimuli are communicated from any part of the body.]

Fibromyalgia syndrome (FMS) is a widespread disorder of unknown etiology affecting 2-4% of the general population in which women are about nine times more likely to develop fibromyalgia than men.(1)

Nonetheless, several hypotheses have been advanced to explain the onset of symptoms. One of these supports a reduction of diffuse noxious inhibitory controls (DNIC) in fibromyalgics. (2) Another hypothesis comes from the fact that the higher prevalence of FMS in women should be related to sex hormones (SH).

The goal of this study was to examine DNIC’s efficiency in relation to the menstrual cycle of women with FMS.

We measured DNIC recruitment and blood level of testosterone (T), estrogens (E) and progesterone (P) at three phases (lutheal, ovulation and menstrual) of a regular menstrual cycle in women with FMS. [Note: The lutheal - or luteal – phase involves build-up of the uterus lining after ovulation, to accept an embryo should conception occur.]

DNIC were activated by the persistent pain stimulation (PPS) procedure, which consists in a continuous nociceptive heat stimulation using a constant temperature thermode for two minutes (at the forearm) producing temporal summation of pain.(3)

DNIC activity was then indexed by comparing temporal summation effects recorded before and after a two minutes immersion of the contralateral arm in cold water (12°C).

FMS patients reported similar pain ratings before and after the immersion procedure in menstrual (low E and P) and ovulation phases (high E, low P).

However, they reported less pain after the immersion procedure during the lutheal phase (low E, high P). This pain diminution showed the analgesic effect caused by the activation of the DNIC.

Moreover, SH analysis showed that FMS patients have normal levels of T, E and P.

These results suggest that endogenous pain control mechanisms in FM female patients are modulated by menstrual cycle.

1. Wolfe, J Musculoskelet Pain, 1993;
2. Julien, Pain, 2005;
3. Tousignant-Laflamme, Brain Research, 2008.)

Source: American Pain Society Annual Scientific Conference, May 2009, Poster #165. Paul-Savoie E, Bourgault P, Tousignant-Laflamme Y, Pagé C, Marchand S; University of Sherbrooke, Sherbrooke, Quebec, Canada.





Post a Comment

Featured Products From the ProHealth Store
Ultra ATP+, Double Strength Mitochondria Ignite™ with NT Factor® Optimized Curcumin Longvida®

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function

Natural Remedies

The Guaifenesin Story: A centuries-old bark extract used for clearing the airways – now key to a popular FM symptom-reversal protocol The Guaifenesin Story: A centuries-old bark extract used for clearing the airways – now key to a popular FM symptom-reversal protocol
Secret Nutrient for Radiant Skin Secret Nutrient for Radiant Skin
Sleep Like a Baby in Nature's Cradle Sleep Like a Baby in Nature's Cradle
Ubiquinol - A More Advanced Form of the Energy Producing Nutrient CoQ-10 Ubiquinol - A More Advanced Form of the Energy Producing Nutrient CoQ-10
Eating Fat is Good... Maybe... Could Be... Sometimes Eating Fat is Good... Maybe... Could Be... Sometimes

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map