Activate Now
 
ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Patient Insights into the Design of Technology to Support a Strengths-Based Approach to Health Care.

SURVEY: Weight Management & Chronic Illness

Japanese green tea consumers have reduced risk of dementia

Do Nothing, Accomplish Everything! The Connection Between Breathing and Healing

Meet the ProHealth Editors

Best Herbs to Help With Insomnia

Choline: Why You Should Eat Your Egg Yolks and Take Krill

Calcium, vitamin D supplementation associated improved stroke recovery

Acupressure reduced fatigue in breast cancer survivors

More positive evidence for melatonin in breast cancer battle

 
Print Page
Email Article

HHS: SAM-e Studies Promising for Osteoarthritis, Depression, Liver Disease

  [ 81 votes ]   [ Discuss This Article ]
www.ProHealth.com • October 9, 2002



S-adenosyl-L-methionine (SAM-e) may be useful for depression, osteoarthritis and liver disease, according to an evidence report released by the Agency for Healthcare Research and Quality (AHRQ), an arm of the Department of Health and Human Services (HHS).

The AHRQ meta-analysis included 99 articles representing 102 individual studies, which were broken down into 47 depression studies, 14 osteoarthritis studies and 41 liver disease studies.

A panel of technical experts was established to advise the researchers throughout their study of SAM-e. In terms of depression, the researchers concluded SAM-e was statistically superior to placebo, and it performed similarly to conventional antidepressant treatment.

As for its ability to decrease osteoarthritis pain, SAM-e performed more effectively than placebo and similarly to non-steroidal, anti-inflammatory medication.

For liver disease, researchers studied SAM-e's efficacy for reducing intrahepatic cholestasis of pregnancy and intrahepatic cholestasis associated with liver disease. In pregnancy, this condition--which is characterized by a failure of bile flow through the liver and is manifested in itchy hands and feet and jaundice--can cause premature delivery or fetal death.

In the event of intrahepatic cholestasis not associated with pregnancy, the condition is a relatively common complication of a number of acute and chronic liver diseases. SAM-e was found to decrease serum bilirubin levels (a marker of cholestasis) compared to placebo, although traditional therapy was found to be superior to SAM-e in this population. For intrahepatic cholestasis caused by liver disease, SAM-e patients were twice as likely to demonstrate a reduction in pruritus (jaundice) compared to placebo. Researchers noted there were too few studies comparing SAM-e to pharmaceutical treatment in this population to allow for a pooled analysis.

AHRQ concluded its summary by noting existing SAM-e research indicates a number of promising areas for future research with SAM-e. For example, studies elucidating the pharmacology of SAM-e and clinical trials are needed, and a better understanding of the risk-to-benefit ratio of SAM-e compared to conventional therapy--especially for depression and osteoarthritis--is very important, according to AHRQ.

In addition, the summary stated dose-escalation studies have not been performed with oral SAM-e for depression, osteoarthritis or liver disease. Any future trials investigating this point would require large numbers of patients with homogeneous diagnoses and focus on significant clinical outcomes, according to the AHRQ.




Post a Comment

Featured Products From the ProHealth Store
Ultra EPA  - Fish Oil FibroSleep™ Energy NADH™ 12.5mg

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
Natural Pain Relief Supplements

Featured Products

Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%

Natural Remedies

Rejuvenating the Brain - How PQQ Helps Power Up Mental Processing Rejuvenating the Brain - How PQQ Helps Power Up Mental Processing
Natural Relief for Soreness, Pain and Swelling - Putting Out the Fire Natural Relief for Soreness, Pain and Swelling - Putting Out the Fire
The Curcumin Revolution: 'Golden' Ticket to Better Health The Curcumin Revolution: 'Golden' Ticket to Better Health
The Surprising Benefits of Probiotics - What You Didn't Know The Surprising Benefits of Probiotics - What You Didn't Know
The Guaifenesin Story: A centuries-old bark extract used for clearing the airways – now key to a popular FM symptom-reversal protocol The Guaifenesin Story: A centuries-old bark extract used for clearing the airways – now key to a popular FM symptom-reversal protocol

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE AND SAVE 15% NOW*
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map