ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

16 Tips from 16 Years Sick

Fibromyalgia Fare Fit for All Seasons

New Study Shows Artificial Sweeteners Lead to Diabetes

Essential Oils — An Effective and Healthy Option to Treat Headaches

Antioxidant treatment could halt neurodegeneration in early Parkinson's

Higher vitamin D levels associated with less severe disease in NAFLD patients

Krill Oil: Make This Omega-3 Supplement Part of Your Health Regimen

How zinc helps fight esophageal cancer

Everything You Need to Know About Black Cohosh

Low vitamin D levels predict ED in diabetics

 
Print Page
Email Article

Clinical Case Report: Ultrastructural Evidence of Skeletal Muscle Mitochondrial Dysfunction in Patients With Subclinical Hypothyroidism – Source: Thyroid Science, June 2009

  [ 100 votes ]   [ Discuss This Article ]
By Michael E. Dunn, Thomas G. Manfredi, et al. • www.ProHealth.com • July 4, 2009


[Note: to read the full text of this article free, click here.]

Objective: The lack of overt signs and symptoms and controversies surrounding the thyroid stimulating hormone (TSH) reference range variability make the management of subclinical hypothyroidism (sHT) a challenge.

Because muscle cramps and weakness have been noted in subclinical hypothyroidism, histological skeletal muscle examination may be of diagnostic significance, as the presence of abnormalities would substantiate a significant consequence of the mild thyroid failure presumed to be present in the individual with subclinical hypothyroidism.

The objective of this study was to investigate the ultrastructural and histological changes of skeletal muscle associated with subclinical hypothyroidism.

Design: Skeletal muscle biopsies from the vastus lateralis were obtained from four subjects with sHT. Samples were fixed, sectioned, and stained for quantitative and qualitative electron and light microscopic analysis.

Main Outcome: Analyses revealed characterizable morphological and ultrastructural alterations and quantitative mitochondrial variations between subjects, indicative of skeletal muscle mitochondrial dysfunction in subclinical hypothyroidism patients.

 

For the 4 subjects, mean mitochondrial perimeter (MP) was 1.09 ± 0.312 ?, mean mitochondrial area (MA) was 0.10 ± 0.05 ?², and mean mitochondrial volume density was 1.92 ± 0.95.

Conclusions: The observed and quantified mitochondrial alterations and the noted morphological and ultrastructural alterations identify previously undocumented pathological skeletal muscle alterations associated with subclinical hypothyroidism.

The observed morphological and ultrastructural alterations lend support to a trend of progression of subclinical hypothyroidism into overt hypothyroidism as a result of mitochondrial dysfunction and associated metabolic shift.

The identification of these skeletal muscle alterations as sequelae of subclinical hypothyroidism may lend convincing objective evidence of a pathophysiologically significant abnormality in patients with subclinical hypothyroidism.

If so, this should diminish the substantial resistance to treatment of these patients at an early stage of disease and attenuate the progression to overt hypothyroidism.

Source: Thyroid Science, June 2009; 4(6):CR1-8. Dunn ME, Hennessey JV, Cosmas AC, Lamont LS, Manfredi TG. Department of Kinesiology, University of Rhode Island, Kingston, Rhode Island; Division of Endocrinology, Rhode Island Hospital, Brown University School of Medicine, Providence, Rhode Island, USA. [E-mail: manfredi@uri.edu]





Post a Comment

Featured Products From the ProHealth Store
Ultra EPA  - Fish Oil Ultra ATP+, Double Strength Energy NADH™ 12.5mg


Article Comments



Be the first to comment on this article!

Post a Comment


 
Optimized Curcumin Longvida with Omega-3

Featured Products

Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength

Natural Remedies

"It's Not Easy Being Green" - But It Is Healthy
Cell-Charging Compound Gives Steady Energy to Fibromyalgia & Chronic Fatigue Patients Cell-Charging Compound Gives Steady Energy to Fibromyalgia & Chronic Fatigue Patients
The Revolutionary 'Good Fat' That Promotes Heart, Brain, Bone and Joint Health The Revolutionary 'Good Fat' That Promotes Heart, Brain, Bone and Joint Health
The Crucial Role CoQ10 Plays in Fibromyalgia and ME/CFS The Crucial Role CoQ10 Plays in Fibromyalgia and ME/CFS
Looking for Energy? Turn to Plants. Looking for Energy? Turn to Plants.

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map