A urine test to diagnose Interstitial Cystitis (IC) has been developed by Sonia L. Planey, PhD, and her team at The Commonwealth Medical College in Scranton, Pennsylvania. IC is a painful chronic bladder disorder involving inflammation along the wall of the bladder.
The new, patent-pending test detects the presence of antiproliferative factor (APF), the urinary marker unique to IC patients discovered by Susan Keay MD, PhD, and her research team at University of Maryland. [APF appears to profoundly inhibit the normal proliferation of cells in the bladder wall by inducing changes in gene expression and may play an important role in the pathogenesis of interstitial cystitis.]
The test is said to take as little as 30 minutes and will be easier and less costly for patients than invasive cystoscopy with hydrodistention, often used to help diagnose IC (with an accuracy rate of less than 75%).
The Commonwealth Medical College team plans to assess the accuracy and effectiveness of the test in patients. Dr. Planey is Assistant Professor of Biochemistry in the Basic Sciences Department at this newly formed medical college.
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Source: Interstitial Cystitis Association news release, Jul 24, 2009