ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Ultrasound Therapy for Fibromyalgia and Lyme Disease

Curcumin: The All In One Solution, Part 2

What Are the Benefits of Vitamin K2?

Vitamin D deficiency + high fat diet = metabolic syndrome

Why You Should Take Your Apple Cider Vinegar at Night

Use Burdock Oil to Promote Healthy Hair Growth

AMA journal associates iron deficiency with hearing loss

Meet Your Weight Loss Goals

People with forms of early-onset Parkinson's disease may benefit from boosting niacin in diet, resea...

Lutein linked to preservation of crystallized intelligence

 
Print Page
Email Article

Chemopreventive and renal protective effects for docosahexanoic acid (DHA): Implications of C-reactive protein and lipid peroxides – Source: Cell Division, Apr 2, 2009

  [ 69 votes ]   [ Discuss This Article ]
By ME El-Mesery, A El-Mowafy, et al. • www.ProHealth.com • August 6, 2009


[Note: To read the full text of this open access article demonstrating that fish oil (DHA) may elicit natural anti-tumor effects superior to those achieved with chemotherapy, click here. Cisplatin is a commonly used chemotherapy drug.]

Background: The fish oil-derived omega-3 fatty acids, like docosahexanoic acid (DHA), claim a plethora of health benefits. We currently evaluated the antitumor effects of DHA, alone or in combination with cisplatin (CP) in the EAC solid tumor mice model [mice that develop tumors when injected with breast cancer cells], and monitored concomitant changes in:

• Serum levels of C-reactive protein (CRP) [C-reactive protein is a marker of inflammation in the body],

• Lipid peroxidation (measured as malondialdehyde; MDA) [lipid peroxidation is free radical damage to the lipids in cell membranes],

• And leukocytic count (LC) [leukocytic count is white blood cell count; leukocytosis is elevated leukocyte count, associated with infection or inflammatory processes].

Further, we verified the capacity of DHA to ameliorate the lethal, cisplatin-induced nephrotoxicity [kidney damage] in rats and the molecular mechanisms involved therein.

Results:

EAC-bearing mice exhibited markedly elevated leukocytic count (2-fold), C-reactive protein (11-fold) and malondialdehyde levels (2.7-fold).

DHA (125, 250 mg/kg) elicited significant, dose-dependent reductions in tumor size (38%, 79%; respectively), as well as in leukocytic count, C-reactive protein and malondialdehyde levels.

These effects for cisplatin were appreciably lower than those of DHA (250 mg/kg).

Interestingly, DHA (125 mg/kg) markedly enhanced the chemopreventive effects of cisplatin and boosted its ability to reduce serum C-reactive protein and malondialdehyde levels.

Correlation studies revealed a high degree of positive association between tumor growth and each of C-reactive protein (r = 0.85) and leukocytosis (r = 0.89), thus attesting to a diagnostic/prognostic role for C-reactive protein.

On the other hand, a single cisplatin dose (10 mg/kg) induced nephrotoxicity in rats that was evidenced by proteinuria, deterioration of glomerular filtration rate (GFR, -4-fold), a rise in serum creatinine/urea levels (2 to 5-fold) after 4 days, and globally-induced animal fatalities after 7 days. Kidney-homogenates from cisplatin-treated rats displayed significantly elevated MDA- and TNF-?-, but reduced GSH-levels.

Rats treated with DHA (250 mg/kg, but not 125 mg/kg) survived the lethal effects of cisplatin, and showed a significant recovery of GFR; while their homogenates had markedly-reduced MDA- and TNF-?-, but increased GSH- levels. Significant association was detected between creatinine level and those of MDA (r = 0.81), TNF-? ) r = 0.92) and GSH (r = -0.82); implying causal relationships.

Conclusion:

• DHA elicited prominent chemopreventive effects [interference with cancer progression] on its own,

• And appreciably augmented those of cisplatin as well.

The extent of tumor progression in various mouse groups was highly reflected by C-reactive protein levels (thus implying a diagnostic/prognostic role for C-reactive protein).

Further, this study is the first to reveal that DHA can obliterate the lethal cisplatin-induced nephrotoxicity and renal tissue injury.

At the molecular level, DHA appears to act by reducing leukocytosis, systemic inflammation, and oxidative stress.

Source: Cell Division, Apr 2, 2009;4(6). PMID: 19341447, by E-Mesery, ME, Al-Gayyar MM, Salem HA, Darweish MM, El-Mowafy AM. Departments of Biochemistry and Pharmacology, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt. [E-mail: aelmowafy@yahoo.com]





Post a Comment

Featured Products From the ProHealth Store
Optimized Curcumin Longvida® Mitochondria Ignite™ with NT Factor® Ultra EPA  - Fish Oil

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health

Natural Remedies

The Curcumin Revolution: 'Golden' Ticket to Better Health The Curcumin Revolution: 'Golden' Ticket to Better Health
Red Yeast Rice - Natural Option for Supporting Healthy Cholesterol Red Yeast Rice - Natural Option for Supporting Healthy Cholesterol
Breaking Through the Mental Fog Breaking Through the Mental Fog
The Guaifenesin Story: A centuries-old bark extract used for clearing the airways – now key to a popular FM symptom-reversal protocol The Guaifenesin Story: A centuries-old bark extract used for clearing the airways – now key to a popular FM symptom-reversal protocol
Natural Bladder Control, Go Less and Live More Natural Bladder Control, Go Less and Live More

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map