ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Is Magnesium the Missing Link in Your Heart Healthy Routine?

More evidence for calorie restriction’s longevity effect

A Little Zinc Goes a Long Way

Supplementation with vitamin D associated with improved testosterone, erectile function among middle...

Vitamin D deficiency increases risk of chronic headache

VIDEO: The Best Brain Foods That Help Increase Your Memory!

Get the Most From Your Green Tea

Iron (And More) For Lasting, Natural Energy

Metabolic syndrome increases the need for vitamin E

Supplement combo improves bone density, mood, in postmenopausal women

 
Print Page
Email Article

Can Mifepristone Improve Gulf War Illness Symptoms? Trial at Mount Sinai Intends to Find Out

  [ 11 votes ]   [ 1 Comment ]
www.ProHealth.com • September 1, 2009


“A positive outcome would provide a new therapeutic avenue for treating ill gulf War veterans, for whom there are currently few treatment options.”

Presentations at the Military Health Research Forum, convened to share information on treating Gulf War Illness (GWI), Aug 31-Sep 3 in Kansas City, MO, include a paper on this ongoing trial at Mount Sinai Medical School in New York:
A Randomized, Double-Blind, Placebo-Controlled, Crossover Trial of Mifepristone in Gulf War Veterans with Chronic Multisymptom Illness (CMI)

The trial is funded and managed by the DOD's Gulf War Illnesses Research Program and Congressionally Directed Medical Research Programs, respectively.

In summary, according to a related news release:

• A large percentage of Gulf War veterans - estimates range from 34% to 65% - continue to suffer from chronic multi-symptom illness, also known as GWI.

• Symptoms can include fatigue, joint pain, headache, rash and cognitive problems, which may reflect altered regulation of the hypothalamic-pituitary-adrenal (HPA) axis.

• The HPA axis is responsible for regulating many things in the body, from the immune system and energy usage, to controlling reactions to stress and trauma.

• Abnormal functioning of the HPA leads to negative effects on many systems in the body, including the immune system and the nervous system.

• Studies have shown that veterans of the 1991 Gulf War have an enhanced [exacerbated] neuroendocrine response to a specific type of hormone called glucocorticoids.

• The increased physical response is associated with chronic fatigue syndrome, fibromyalgia, and post-traumatic stress disorder, all of which can occur with chronic multisymptom illness.

• This study aims to determine if the prescription drug mifepristone, a glucocorticoid receptor antagonist could decrease the enhanced response and therefore improve the physical and mental health and cognitive functioning of Gulf War veterans. [Commonly known as 'the morning after pill,' mifepristone has been studied as therapy for a variety of ills, from uterine fibroids to major depression.]

• Researchers from the Mount Sinai School of Medicine in New York and the James J. Peters VA Medical Center in the Bronx are evaluating veterans of the 1991 Gulf War with chronic multisymptom illness but without any exclusionary psychiatric or medical conditions.

• All subjects will be treated for a six-week time period with the mifepristone compound and then, a month later, treated with an alternative compound (placebo) in a crossover design. [To see the ClinicalTrials.gov listing of the trial - NCT00691067 - click here.]

• Researchers will then evaluate physical health, cognitive functioning and mental health in subjects and determine if there is improvement in these areas in relation to mifepristone administration.

"A positive outcome would provide a new therapeutic avenue for treating ill Gulf War veterans, for whom there are currently few treatment options," says principal investigator Julia Golier, MD. "The trial will also provide an important proof of concept of whether this type of drug will improve physical health and cognitive outcomes in symptomatic Gulf War veterans, thus improving their overall health."

Source: US Department of Defense Congressionally Directed Medical Research Programs, news release Sep 1, 2009




Post a Comment

Featured Products From the ProHealth Store
Energy NADH™ 12.5mg Ultra EPA  - Fish Oil FibroSleep™

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments Post a Comment

GW dont know about this Study
Posted by: Jagmedic
Sep 25, 2009
The advisory committess on gulf war veterans and gulf war illness research can not be heard. The last two VA secertaries have not inacted anything the Committess recommendated. VA- public affairs office and VSo's failed to communicate widely. Like in the Trial at Mount Sinai, the Researchers, Scinetists are saying they are unable to find these disabled veterans. http://post-deployment.blogspot.com/
Reply Reply
 
NAD+ Ignite with Niagen

Featured Products

Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength

Natural Remedies

Optimize Your Immune System Naturally: Thymic Protein A Optimize Your Immune System Naturally: Thymic Protein A
Secret Nutrient for Radiant Skin Secret Nutrient for Radiant Skin
Restoring Gut Health: How to Create a Firewall Against Toxins Entering the Gut Wall Restoring Gut Health: How to Create a Firewall Against Toxins Entering the Gut Wall
How to Jump-start and Sustain Energy Production in CFS How to Jump-start and Sustain Energy Production in CFS
Repair Damaged Mitochondria and Reduce Fatigue Up to 45% Repair Damaged Mitochondria and Reduce Fatigue Up to 45%

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map