ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Fighting Heartburn and Gerd Naturally – And Safely!

Vital Molecule Increases Cellular Energy and Improves Cognitive Function

Natural Bladder Control, Go Less and Live More

Top Vitamin and Mineral Deficiencies — Are You at Risk?

Trimming the spare tire: Canola oil may cut belly fat

How Pomegranate May Protect Against Cancer

Omega Fix for Obesity: How the Right Fats Fight Fat

Curcumin Reverses the Cellular Damage of Chronic Stress

The Onion: Cancer Fighter and Food Preserver

Probiotics improve cognition in Alzheimer's patients

 
Print Page
Email Article

Randomized, Placebo-controlled, Double-blind Trial of Valomaciclovir (VALM) for Infectious Mononucleosis (IM) – Source: Interscience Conference on Antimicrobial Agents & Chemotherapy, Sep 14, 2009

  [ 15 votes ]   [ Discuss This Article ]
By Henry H Balfour Jr., et al. • www.ProHealth.com • September 16, 2009


[Note: As described in a Los Angeles Times article, “Antiviral drug found to reduce severity of mono,” viral load was reduced in treated youngsters, who averaged a 50% symptom improvement in 7.6 days vs. 11.1 days for placebo. The next challenge: identify factors that may justify treatment – e.g., characteristics that appear linked to more severe illness, or to later development of illnesses such as ME/CFS.]

Background: Infectious mononucleosis (IM) causes substantial loss of productivity in teenagers and young adults. We conducted an investigator-initiated clinical trial of the guanosine nucleoside prodrug Valomaciclovir (VALM) for infectious mononucleosis under an investigator IND.

Methods: Subjects over the age of 15 with acute infectious mononucleosis were randomized to 21 days of VALM 4 g/day or placebo (PBO) and followed for 6 mo. Clinical, virologic, immunologic and pharmacologic observations were made during 10 visits.

Results:
21 subjects ages 16 to 24 yr (median age, 19.6 yr) enrolled a median of 6 days after onset of infectious mononucleosis confirmed due to primary Epstein-Barr virus (EBV) infection. 11 were assigned to VALM and 10 to PBO.

• VALM subjects had significantly faster clinical improvement than PBO recipients as documented by comparing the slopes of the plots of their physical exam/symptom scores from each visit during the treatment period (95% confidence intervals did not overlap; P<0.05).

• Severity of illness and SF12 scores improved faster in VALM subjects but rates were not statistically significant.

• VALM produced a significant decrease in median EBV load in the oral compartment vs PBO (oral cell pellet, P=0.03; oral supernatant, P=0.001, unpaired t test, 2-sided).

• The proportion of subjects who had at least a 2 log10 decrease in EBV load in the oral compartment was also significantly different (VALM 8/11; PBO 2/10; P=0.03, Fisher exact test, 2-sided).

• No differences were found in clearance of EBV DNAemia, CD8:CD4 ratios, CD8 lymphocytosis, or CD8 responses to lytic and latent EBV tetramers in the VALM vs PBO subjects.

• 9 of 11 VALM subjects had at least 1 plasma concentration of H2G, the parent compound of VALM, above the in vitro IC50 for EBV in subject-derived lymphoblastoid cells, which is 2.1 micromolar.

Conclusions:
This is the first demonstration of a clinical benefit and an in vivo antiviral effect of VALM in acute infectious mononucleosis due to primary EBV infection.

This study encourages additional investigation of the role of VALM in the management of diseases associated with EBV.

[ClinicalTrials.gov Trial: NCT00575185]

Source: Interscience Conference on Antimicrobial Agents & Chemotherapy, Sep 14, 2009, San Francisco. Presentation Number V-1256a; Session 146 – Herpes Viruses and Other Viral Infections in Immunocompromised Hosts. By Balfour HH, Vezina HE, Hogquist KA, Brundage RC, Anderson BJ, Odumade OA. University of Minnesota, Minneapolis, USA.





Post a Comment

Featured Products From the ProHealth Store
Ultra ATP+, Double Strength Mitochondria Ignite™ with NT Factor® Ultra EPA  - Fish Oil


Article Comments



Be the first to comment on this article!

Post a Comment


 
Natural Pain Relief Supplements

Featured Products

Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium

Natural Remedies

Prepare Yourself for Cold & Flu Season Prepare Yourself for Cold & Flu Season
The Guaifenesin Story: A centuries-old bark extract used for clearing the airways – now key to a popular FM symptom-reversal protocol The Guaifenesin Story: A centuries-old bark extract used for clearing the airways – now key to a popular FM symptom-reversal protocol
The Remarkable Benefits of Reishi Medicinal Mushrooms The Remarkable Benefits of Reishi Medicinal Mushrooms
Itching to Find Dry Skin Relief? Itching to Find Dry Skin Relief?
Health Benefits Are Brewing in Green Tea Health Benefits Are Brewing in Green Tea

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map