ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

15 Health Benefits of Chia Seeds, According to Science

Tangerine Oil: A Citrusy Essential Oil With Well-Rounded Uses

Magnesium Deficiency Raises Your Risk of Many Chronic Ailments

CoQ10's Potential Capabilities for Your Health

Testosterone replacement therapy associated with improved urinary, sexual function

How Can Melatonin Benefit You?

Cloves: Boost Your Immune System the Sweet and Spicy Way

The Many Potential Health Benefits of Curcumin

8 Chia Seed Recipes

Cinnamon Health Benefits Proven

 
Print Page
Email Article

New Study Links Fibromyalgia and Chronic Fatigue Syndrome to Low Vitamin B12 and High Homocysteine in Cerebrospinal Fluid

  [ 192 votes ]   [ Discuss This Article ]
www.ProHealth.com • August 1, 1998


Studies regarding the correlation between coronary artery disease incidence and abnormally high blood levels of the amino acid homocysteine have been appearing with increasing regularity. Relatively overlooked among the research articles is a recently published Swedish study, the results of which demonstrate consistently high homocysteine levels and low concentrations of vitamin B12 in the cerebrospinal fluid (CSF) of patients meeting established clinical criteria for Chronic Fatigue Syndrome and Fibromyalgia

Chronic Fatigue Syndrome and Fibromyalgia are two disorders only recently widely recognized clinically, and though not identical, share in common many features which include fatigue, reduced pain thresholds and depression. Criteria for Chronic Fatigue Syndrome and Fibromyalgia diagnosis have been established by the Centers for Disease Control and the American College of Rheumatology, respectively.

In the Swedish study by Regland M.D., Ph.D., et al., published in the Scandinavian Journal of Rheumatology, twelve female patients that met criteria for both Fibromyalgia and Chronic Fatigue Syndrome were studied along with a control group of eighteen healthy women. Subjects were also evaluated using a subset of items from the Comprehensive Psychopathological Rating Scale. The aim of the study was to determine factors present in cerebrospinal fluid related to homocysteine metabolism that correlate with Chronic Fatigue Syndrome and Fibromyalgia.

The mean value of cerebrospinal fluid homocysteine in the patient group was over three times the mean level in the control group, a highly significant difference. Cerebrospinal fluid vitamin B12 levels measured below normal in the majority (7/12) of Fibromyalgia and Chronic Fatigue Patients.

On the other hand, Serum levels of homocysteine, folate, and vitamin B12 did not significantly deviate from normal ranges in the Fibromyalgia / Chronic Fatigue Syndrome patients. The authors interpret their findings to mean that biochemical events leading to high homocysteine levels in their patient group occur predominantly, if not exclusively, within the brain itself. Low vitamin B12 levels in the cerebrospinal fluid may reflect disruption of the mechanism of transport across the blood brain barrier. Incidentally, according to health practitioners who have used vitamin B12 therapeutically, high doses are often required to achieve measurable effects.

Homocysteine is a sulfur-containing amino acid involved in several important methyl and sulfur transfer reactions. Excessive accumulation of homocysteine in the body fluid compartments is normally prevented by degradation through two enzymatic reactions called transsulfuration and remethylation. Importantly, these enzyme reactions depend on folate, vitamin B 6 (pyridoxal 5- phosphate), and vitamin B12 (cobalamin) as cofactors.

When functioning properly, the enzymatic break-down of homocysteine forms methionine, which can then be converted to S-adenosyl-methionine (SAM). SAM is an important cofactor in the metabolism of central nervous system monoamine neurotransmitters, including dopamine, norepinephrine and serotonin. It has also been used successfully to treat both Fibromyalgia and depression. Unfortunately, SAM was not measured in the Swedish study.

Another explanation for high cerebrospinal fluid homocysteine levels was considered by the Swedish authors. Nitric oxide, which is an inhibitor of the enzyme that converts homocysteine to methionine, is produced as a result of inflammatory reactions. Most of the patients in the study, in addition to their neurological condition, had accompanying symptoms of viral or bacterial infections. Theoretically, the inflammation caused by these infections increased nitric oxide levels, which in turn increased homocysteine levels.

In conclusion, this study provides convincing preliminary evidence that high homocysteine levels in cerebrospinal fluid homocysteine is an underlying factor in patients suffering from Fibromyalgia and Chronic Fatigue Syndrome. Low vitamin B12 levels in cerebrospinal fluid and possibly low SAM levels are implicated as contributing factors. Additional evidence from other studies further support the idea that deficiencies in enzymatic pathways in the brain involving vitamin B12 , homocysteine, and folic acid underlie a range of neurological disorders. Deficiencies in these essential biochemical pathways in the brain should be considered by health practitioners in the evaluation of successful interventions for reversing symptoms of Fibromyalgia, Chronic Fatigue Syndrome, and other neurological conditions.



Post a Comment

Featured Products From the ProHealth Store
Methyl B-12 Ultra ATP+, Double Strength Methyl B-12


Article Comments



Be the first to comment on this article!

Post a Comment


 
Optimized Curcumin Longvida with Omega-3

Featured Products

Methyl B-12 Methyl B-12
Promote energy levels and mental sharpness
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Methyl B-12 Methyl B-12
Promotes Energy Levels & Mental Sharpness

Natural Remedies

Fighting Fatigue with Ground-breaking French Oak Wood Extract Fighting Fatigue with Ground-breaking French Oak Wood Extract
Research Links Green Tea to Weight Loss Research Links Green Tea to Weight Loss
Looking for Energy? Turn to Plants. Looking for Energy? Turn to Plants.
Curcumin - a Golden Gift of Nature with Benefits Still Untold Curcumin - a Golden Gift of Nature with Benefits Still Untold
Strontium - The Missing Mineral for Strong Bones Strontium - The Missing Mineral for Strong Bones

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map