ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

10 Fibro-Friendly Foods with a Bonus: Beautiful Skin

Fight Back! Win the War Being Waged Against Your Immune System

Studies Show that Magnesium L-threonate Improves Brain Plasticity, Leading to Direct and Significant...

Clary Sage Oil May Be Pricey, but Its Benefits Are Priceless

Component of red wine, grapes can help to reduce inflammation, study finds

Poly MVA: A Novel Therapy for Increasing Energy, Repairing DNA, and Promoting Overall Health

Pumpkin Pie Turmeric Breakfast Smoothie - Vegan + Gluten-Free

Vitamin D supplementation extends life in mouse model of Huntington's disease

What’s Fenugreek Good For?

Omega-3 fatty acid stops known trigger of lupus

Print Page
Email Article

New Study Links Fibromyalgia and Chronic Fatigue Syndrome to Low Vitamin B12 and High Homocysteine in Cerebrospinal Fluid

  [ 192 votes ]   [ Discuss This Article ] • August 1, 1998

Studies regarding the correlation between coronary artery disease incidence and abnormally high blood levels of the amino acid homocysteine have been appearing with increasing regularity. Relatively overlooked among the research articles is a recently published Swedish study, the results of which demonstrate consistently high homocysteine levels and low concentrations of vitamin B12 in the cerebrospinal fluid (CSF) of patients meeting established clinical criteria for Chronic Fatigue Syndrome and Fibromyalgia

Chronic Fatigue Syndrome and Fibromyalgia are two disorders only recently widely recognized clinically, and though not identical, share in common many features which include fatigue, reduced pain thresholds and depression. Criteria for Chronic Fatigue Syndrome and Fibromyalgia diagnosis have been established by the Centers for Disease Control and the American College of Rheumatology, respectively.

In the Swedish study by Regland M.D., Ph.D., et al., published in the Scandinavian Journal of Rheumatology, twelve female patients that met criteria for both Fibromyalgia and Chronic Fatigue Syndrome were studied along with a control group of eighteen healthy women. Subjects were also evaluated using a subset of items from the Comprehensive Psychopathological Rating Scale. The aim of the study was to determine factors present in cerebrospinal fluid related to homocysteine metabolism that correlate with Chronic Fatigue Syndrome and Fibromyalgia.

The mean value of cerebrospinal fluid homocysteine in the patient group was over three times the mean level in the control group, a highly significant difference. Cerebrospinal fluid vitamin B12 levels measured below normal in the majority (7/12) of Fibromyalgia and Chronic Fatigue Patients.

On the other hand, Serum levels of homocysteine, folate, and vitamin B12 did not significantly deviate from normal ranges in the Fibromyalgia / Chronic Fatigue Syndrome patients. The authors interpret their findings to mean that biochemical events leading to high homocysteine levels in their patient group occur predominantly, if not exclusively, within the brain itself. Low vitamin B12 levels in the cerebrospinal fluid may reflect disruption of the mechanism of transport across the blood brain barrier. Incidentally, according to health practitioners who have used vitamin B12 therapeutically, high doses are often required to achieve measurable effects.

Homocysteine is a sulfur-containing amino acid involved in several important methyl and sulfur transfer reactions. Excessive accumulation of homocysteine in the body fluid compartments is normally prevented by degradation through two enzymatic reactions called transsulfuration and remethylation. Importantly, these enzyme reactions depend on folate, vitamin B 6 (pyridoxal 5- phosphate), and vitamin B12 (cobalamin) as cofactors.

When functioning properly, the enzymatic break-down of homocysteine forms methionine, which can then be converted to S-adenosyl-methionine (SAM). SAM is an important cofactor in the metabolism of central nervous system monoamine neurotransmitters, including dopamine, norepinephrine and serotonin. It has also been used successfully to treat both Fibromyalgia and depression. Unfortunately, SAM was not measured in the Swedish study.

Another explanation for high cerebrospinal fluid homocysteine levels was considered by the Swedish authors. Nitric oxide, which is an inhibitor of the enzyme that converts homocysteine to methionine, is produced as a result of inflammatory reactions. Most of the patients in the study, in addition to their neurological condition, had accompanying symptoms of viral or bacterial infections. Theoretically, the inflammation caused by these infections increased nitric oxide levels, which in turn increased homocysteine levels.

In conclusion, this study provides convincing preliminary evidence that high homocysteine levels in cerebrospinal fluid homocysteine is an underlying factor in patients suffering from Fibromyalgia and Chronic Fatigue Syndrome. Low vitamin B12 levels in cerebrospinal fluid and possibly low SAM levels are implicated as contributing factors. Additional evidence from other studies further support the idea that deficiencies in enzymatic pathways in the brain involving vitamin B12 , homocysteine, and folic acid underlie a range of neurological disorders. Deficiencies in these essential biochemical pathways in the brain should be considered by health practitioners in the evaluation of successful interventions for reversing symptoms of Fibromyalgia, Chronic Fatigue Syndrome, and other neurological conditions.

Post a Comment

Featured Products From the ProHealth Store
Neuro B-12, Methylcobalamin Neuro B-12, Methylcobalamin Vitamin D3 Extreme™

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products

Article Comments

Be the first to comment on this article!

Post a Comment

Natural Pain Relief Supplements

Featured Products

Neuro B-12, Methylcobalamin Neuro B-12, Methylcobalamin
Promotes Energy Levels & Mental Sharpness
Neuro B-12, Methylcobalamin Neuro B-12, Methylcobalamin
Promote energy levels and mental sharpness
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health

Natural Remedies

Optimize Your Immune System Naturally: Thymic Protein A Optimize Your Immune System Naturally: Thymic Protein A
The Curcumin Revolution: 'Golden' Ticket to Better Health The Curcumin Revolution: 'Golden' Ticket to Better Health
Priming Your Immune System for Cold & Flu Season Priming Your Immune System for Cold & Flu Season
Breaking Through the Mental Fog Breaking Through the Mental Fog
Could a B-12 Deficiency Be Causing Your Symptoms? Could a B-12 Deficiency Be Causing Your Symptoms?

ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
Credit Card Processing
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map