ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

SURVEY: Cognitive Impairment II

Top 3 Nutrients to Detox the Liver and Soothe Digestion

Natural Bladder Control, Go Less and Live More

Study bodes well for low-carb eaters

Top Vitamin and Mineral Deficiencies — Are You at Risk?

Omega Fix for Obesity: How the Right Fats Fight Fat

Potential of Quercetin in the Treatment of Melanoma

How Pomegranate May Protect Against Cancer

Vital Molecule Increases Cellular Energy and Improves Cognitive Function

Trimming the spare tire: Canola oil may cut belly fat

 
Print Page
Email Article

Worse and More Persistent Post-Surgical Pain Appears to Have Genetic Link

  [ 27 votes ]   [ Discuss This Article ]
www.ProHealth.com • November 1, 2009


A study presented at the 2009 Annual Meeting of the American Society of Anesthesiologists highlights the crucial importance of investigating multiple factors when designing studies that attempt to predict the development of persistent pain in patients.

Researchers specializing in anesthesiology and genetics at Oakland University (CA) William Beaumont School of Medicine were surprised to find that:

• Patients who carried a gene known for low sensitivity to pain

• Actually showed higher levels of pain at three months after surgery than other patients.

The study followed 58 patients who had undergone arthroscopic shoulder surgery for rotator cuff repair, a minimally invasive procedure that typically causes little postoperative pain. The patients also received nerve block anesthetics for home use to further reduce any lingering pain.

“Despite aggressive acute pain management, some patients still experienced significant pain and interference with activities that persisted for months, well beyond the usual period of healing,” said Dr. Craig T Hartrick, MD, who is Director of Anesthesiology Research at Oakland U.

The patients who still experienced pain at three months were paired with those who recovered from surgery uneventfully. Those who carried genes that better controlled the release of an enzyme known as COMT (catechol-O-methyl transferase) were examined to see if they resisted postsurgical pain better than the other patients. It has been suggested that patients with the very active form of COMT are protected from the development of temporomandibular joint dysfunction (TMJ), and possibly other forms of pain.

In the current study, patients with high anxiety before surgery had increased pain at three months, lower quality of life and increased feelings of sensitivity to pain. Again, when matched against other patients with similar anxiety levels, the low pain sensitivity COMT patients were actually experiencing the highest pain levels at three months.

“This may be explained due to the tendency for a reduced level of reported anxiety in the low pain sensitivity COMT subgroup of patients,” said Dr. Wendell, Associate Professor of Biological Sciences and Genetics at Oakland University.

Both Dr. Hartrick and Dr. Wendell stressed that developing pain strategies requires studying a vast array of factors, some of which are at least partially influenced by a person’s genetic makeup.

“While this study did not confirm an association between anxiety and COMT type, such an association could explain the apparent paradox in our findings and thus may represent an important confounder affecting pain assessments and pain studies that examine the genetic role of COMT.”

Source: American Society of Anesthesiologists (www.asahq.org) press release, Oct 20, 2009, modified




Post a Comment

Featured Products From the ProHealth Store
Ultra ATP+, Double Strength Optimized Curcumin Longvida® FibroSleep™


Article Comments



Be the first to comment on this article!

Post a Comment


 
Natural Pain Relief Supplements

Featured Products

Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%

Natural Remedies

The New Dual Activation Pain Relief Cream The New Dual Activation Pain Relief Cream
Coconut Oil - Healthy Gifts from the 'Tree of Life' Coconut Oil - Healthy Gifts from the 'Tree of Life'
Mitochondria-Booster NIAGEN® Shows Promise in First Human Clinical Trial Mitochondria-Booster NIAGEN® Shows Promise in First Human Clinical Trial
Breaking Through the Mental Fog Breaking Through the Mental Fog
Herbal Rescue for High Blood Sugar Herbal Rescue for High Blood Sugar

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map