ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Is Magnesium the Missing Link in Your Heart Healthy Routine?

More evidence for calorie restriction’s longevity effect

A Little Zinc Goes a Long Way

Supplementation with vitamin D associated with improved testosterone, erectile function among middle...

Vitamin D deficiency increases risk of chronic headache

VIDEO: The Best Brain Foods That Help Increase Your Memory!

Get the Most From Your Green Tea

Iron (And More) For Lasting, Natural Energy

Metabolic syndrome increases the need for vitamin E

Supplement combo improves bone density, mood, in postmenopausal women

 
Print Page
Email Article

Consecutive brain SPECT surface three-dimensional displays show progression of cerebral cortical abnormalities in Alzheimer's disease.

  [ Not Yet Rated ]   [ Discuss This Article ]
By Shih WJ, Ashford JW, Coupal JJ, Ryo YU, Stipp V, M • www.ProHealth.com • October 1, 1999


PURPOSE: To monitor progression of cerebral blood flow deterioration, this study used consecutive surface SPECT to evaluate the feasibility of brain surface displays (BSD) to follow Alzheimer's disease (AD) to determine whether overtime is a consistent feature of the disease.

METHODS: Eighteen men (mean age, 75.7 years) with probable Alzheimer's disease (AD), with moderate to profound dementia indicated by the Mini-Mental State Examination (MMSE; median score, 10; range, 0 to 19), underwent brain Tc-99m ethyl cysteinate dimer SPECT. Brain SPECTs were obtained using a three-head gamma camera. Brain surface displays (BSD) were reconstructed from transaxial data using a threshold of 55% of the maximum pixel count. A second series of SPECTs were obtained after 5 to 23 months (except for one, which was done after 60 months). Each BSD was graded semiquantitatively, by visual interpretation, from zero to 8 (normal = 0, mild = 2, moderate = 4, severe = 6, and profound = 8) depending on the extent of the perfusion defects in the frontal, temporal, or parietal (or all of these) pattern of AD. MMSE scores were used to calculate "time index" values for estimating severity at the time of the SPECTs.

RESULTS: The initial BSD scores correlated significantly with dementia severity (r = 0.71, P < 0.001). All 18 patients had decreased blood flow on consecutive SPECTs. Scores for BSD progressed at a rate of 2.5 +/- 1.7 points per year and correlated significantly with the time interval between the scans (r = 0.71; P < 0.001).

CONCLUSIONS: The BSDs of SPECT scan data have considerable objective discriminatory power for assessing the severity and progression of AD-related hypoperfusion, particularly in the moderate to profound dementia ranges, and is potentially more reliable than the MMSE. Consecutive BSDs simplify SPECT image interpretation for measuring loss of brain function over time and could be useful for assessing the efficacy of therapeutic interventions for AD patients such as vitamin E and cholinesterase inhibitors.

Source: Clin Nucl Med 1999 Oct;24(10):773-7
PMID: 10512103, UI: 99440654

(Nuclear Medicine Service, VA Medical Center, Lexington, Kentucky 40511, USA.)




Post a Comment

Featured Products From the ProHealth Store
Mitochondria Ignite™ with NT Factor® Ultra EPA  - Fish Oil Vitamin D3 Extreme™

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid

Natural Remedies

Vitamin K-2 – A Key Player in Cardiovascular and Bone Health Vitamin K-2 – A Key Player in Cardiovascular and Bone Health
The Curcumin Revolution: 'Golden' Ticket to Better Health The Curcumin Revolution: 'Golden' Ticket to Better Health
Priming Your Immune System for Cold & Flu Season Priming Your Immune System for Cold & Flu Season
Live Without Anxiety or Stress Live Without Anxiety or Stress
Optimize Your Immune System Naturally: Thymic Protein A Optimize Your Immune System Naturally: Thymic Protein A

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map