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This study investigated the relationship of children's autism symptoms with their toxic metal body burden and red blood cell (RBC) glutathione levels.
In children ages 3 to 8 years, the severity of autism was assessed using four tools: ADOS, PDD-BI, ATEC, and SAS.
Toxic metal body burden was assessed by measuring urinary excretion of toxic metals, both before and after oral dimercaptosuccinic acid (DMSA).
Multiple positive correlations were found between the severity of autism and the urinary excretion of toxic metals.
Variations in the severity of autism measurements could be explained, in part, by regression analyses of urinary excretion of toxic metals before and after DMSA and the level of RBC glutathione (adjusted R2 of 0.22–0.45, P<.005 in all cases).
This study demonstrates a significant positive association between the severity of autism and the relative body burden of toxic metals.
Source: Journal of Toxicology, 2009. DOI:10.1155/2009/532640, by Adams JB, Baral M, Geis E, Mitchell J, Ingram J, Hensley a, Zappia I, Newmark S, Gehn E, Rubin RA, Mitchell K, Bradstreet J, El-Dahr JM. Division of Basic Medical Sciences, and Department of Pediatric Medicine, Southwest College of Naturopathic Medicine, Tempe, AZ; Autism Research Institute, San Diego, CA; Center for Integrative Pediatric Medicine, Tucson; Department of Mathematics, Whittier College, Whittier, CA; International Child Development Resource Center, Phoenix, AZ; Department of Pediatrics, Tulane University School of Medicine, New Orleans, LA,2, USA. [E-mail: email@example.com]