ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Curcumin: The All In One Solution, Part 2

CoQ10 — A Nutritional Powerhouse for Mitochondrial Health

What Are the Benefits of Vitamin K2?

Vitamin D deficiency + high fat diet = metabolic syndrome

Use Burdock Oil to Promote Healthy Hair Growth

Why You Should Take Your Apple Cider Vinegar at Night

AMA journal associates iron deficiency with hearing loss

Lutein linked to preservation of crystallized intelligence

People with forms of early-onset Parkinson's disease may benefit from boosting niacin in diet, resea...

Zinc eaten at levels found in biofortified crops reduces 'wear and tear' on DNA

 
Print Page
Email Article

Antidepressants Generally Helpful for Severe Depression Only; Physician Education Urged - JAMA

  [ 41 votes ]   [ Discuss This Article ]
www.ProHealth.com • January 5, 2010


“True drug effects… were nonexistent to negligible among depressed patients with mild, moderate, and even severe baseline symptoms, whereas they were large for patients with very severe symptoms.”

An analysis of randomized trials indicates that compared with placebo, the magnitude of benefit of antidepressant medications varies with the severity of depressive symptoms, and may provide little benefit for patients with mild or moderate depression - but appear to provide substantial benefit for patients with very severe depression, according to an article published Jan 6 in the Journal of the American Medical Association (JAMA).*

Antidepressant medications are the current standard of treatment for major depressive disorder (MDD), but there is little evidence that they have a specific pharmacological effect relative to placebo for patients with less severe depression, according to background information in the article.

Jay C. Fournier, MA, of the University of Pennsylvania, Philadelphia, and colleagues conducted a meta-analysis to estimate the benefit of antidepressant medications vs. placebo across a wide range of initial symptom severity in patients diagnosed with depression.

The researchers combined data from 6 large-scale, placebo-controlled randomized trials. The studies included 718 adult outpatients.

The authors found that the efficacy of antidepressant medications treatment for depression varied considerably, depending on symptom severity:

“True drug effects (an advantage of antidepressant medications over placebo) were nonexistent to negligible among depressed patients with mild, moderate, and even severe baseline symptoms, whereas they were large for patients with very severe symptoms.

“What makes our findings surprising is the high level of depression symptom severity that appears to be required for clinically meaningful drug/placebo differences to emerge, particularly given the evidence that the majority of patients receiving antidepressant medications in clinical practice present with scores [measures of depression] below these levels.

“Prescribers, policy makers, and consumers may not be aware that the efficacy of medications largely has been established on the basis of studies that have included only those individuals with more severe forms of depression.

“This important feature of the evidence base is not reflected in the implicit messages present in the marketing of these medications to clinicians and the public. There is little mention of the fact that efficacy data often come from studies that exclude precisely those major depressive disorder patients who derive little specific pharmacological benefit from taking medications.

"Pending findings contrary to those reported here and those obtained [in previous studies] by Kirsch et al. and Khan et al., efforts should be made to clarify to clinicians and prospective patients that whereas antidepressant medications can have a substantial effect with more severe depressions, there is little evidence to suggest that they produce specific pharmacological benefit for the majority of patients with less severe acute depressions,” the authors conclude.

____
* Article: JAMA. 2010;303[1]:47-53.

Source: American Medical Association news release, Jan 5, 2010




Post a Comment

Featured Products From the ProHealth Store
Optimized Curcumin Longvida® Ultra ATP+, Double Strength Vitamin D3 Extreme™

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils

Natural Remedies

Help for Soreness and Swelling: What Do Silkworms Have to Do With It? Help for Soreness and Swelling: What Do Silkworms Have to Do With It?
Aching Muscles? Top 10 Nutrients to Take Back Your Life Aching Muscles? Top 10 Nutrients to Take Back Your Life
Sunshine Vitamin Has D-lightful Health Benefits Sunshine Vitamin Has D-lightful Health Benefits
Astaxanthin - A Little-Known but Power-Packed Nutrient Astaxanthin - A Little-Known but Power-Packed Nutrient
When a Good Night's Sleep Is Just a Daydream... When a Good Night's Sleep Is Just a Daydream...

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map