ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Is a Good Night's Sleep at the Top of Your Wishlist?

Ashwagandha Helps Hormones - Aids Arthritis

Why You Should Be Eating More Porcini Mushrooms

A Breathalyzer for Disease?

Tryptophan's Possible Effects for Your Health

How Bacopa Can Help Improve Your Cognitive Function

Black Tea Is Great for Your Gut

Magnesium Reduces Diabetes and Helps Keep You Young

Lavender Aromatherapy Can Ease Pre-Op Anxiety

Mint: Learn More About This Refreshing and Invigorating Herb

 
Print Page
Email Article

Is melatonin involved in the irritable bowel syndrome? – Source: Journal of Physiology and Pharmacology, Oct 2009

  [ 28 votes ]   [ Discuss This Article ]
By P Radwan, et al. • www.ProHealth.com • January 13, 2010


There is substantial evidence that large quantities of melatonin are produced in the gastrointestinal tract. However, is still unclear which is the role of melatonin in digestive system in human physiology and pathophysiology.

In the present study we investigated urinary excretion of a main melatonin metabolite, 6-sulphatoxymelatonin [6-SMLT, a substance produced when melatonin is metabolized], in patients with irritable bowel syndrome (IBS). The investigation was carried out in 67 persons, both sexes, aged 20-45 years old who according to Rome III Criteria were diagnosed as sufferers of constipation (C-IBS, n=21 persons) or diarrhea (D-IBS, n=24 persons) form of irritable bowel syndrome and as healthy subjects (K, n=22), matched for control.

Samples were obtained from the collected diurnal urine. The concentration of 6-sulphatoxymelatonin (6-SMLT) was measured with ELISA method, creatinine (crea) was automatically analyzed with biochemical analyzer and 6-SMLT/crea calculated.

There were statistically significant differences between groups: the 6-SMLT/crea level was:

• Lower in C-IBS (103.86+/- 82.83 ng/mg) and D-IBS (112.72+/-85.29 ng/mg) groups

• Compared to K group (202.7+/-89.28 ng/mg), respectively, p=0.002, p=0.003.

There were no differences between C-IBS and D-IBS groups; however, there were observed differences between men and women with C-IBS.

• The 6-SMLT/crea level was higher in women with C-IBS (139.31+/-96.45)

• Compared to men with C-IBS (35.51+/-41.05) (p=0.04).

These results suggest that different melatonin secretion and metabolism may be involved in the pathogenesis of irritable bowel syndrome.

Source: Journal of Physiology and Pharmacology, Oct 2009;60 Suppl 3:67-70. PMID: 19996484, by Radwan P, Skrzydlo-Radomanska B, Radwan-Kwiatek K, Burak-Czapiuk B, Strzemecka J. Department of Gastroenterology, Medical University of Lublin, Poland.





Post a Comment

Featured Products From the ProHealth Store
Ultra EPA  - Fish Oil Mitochondria Ignite™ with NT Factor® Energy NADH™ 12.5mg


Article Comments



Be the first to comment on this article!

Post a Comment


 
Optimized Curcumin Longvida with Omega-3

Featured Products

Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health

Natural Remedies

Natural Relief for Soreness, Pain and Swelling - Putting Out the Fire Natural Relief for Soreness, Pain and Swelling - Putting Out the Fire
When a Good Night's Sleep Is Just a Daydream... When a Good Night's Sleep Is Just a Daydream...
The Revolutionary 'Good Fat' That Promotes Heart, Brain, Bone and Joint Health The Revolutionary 'Good Fat' That Promotes Heart, Brain, Bone and Joint Health
The Remarkable Benefits of Reishi Medicinal Mushrooms The Remarkable Benefits of Reishi Medicinal Mushrooms
Physically and Mentally Exhausted? How to Restore Energy at Its Source Physically and Mentally Exhausted? How to Restore Energy at Its Source

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map