ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

10 Fibro-Friendly Foods with a Bonus: Beautiful Skin

Fight Back! Win the War Being Waged Against Your Immune System

Studies Show that Magnesium L-threonate Improves Brain Plasticity, Leading to Direct and Significant...

Clary Sage Oil May Be Pricey, but Its Benefits Are Priceless

Component of red wine, grapes can help to reduce inflammation, study finds

Poly MVA: A Novel Therapy for Increasing Energy, Repairing DNA, and Promoting Overall Health

Pumpkin Pie Turmeric Breakfast Smoothie - Vegan + Gluten-Free

Vitamin D supplementation extends life in mouse model of Huntington's disease

Omega-3 fatty acid stops known trigger of lupus

Conquer Your Email Inbox, Increase Productivity and Reduce Stress

Print Page
Email Article

Study of Tissue Acidity Leads to Better Understanding of Pain

  [ 61 votes ]   [ Discuss This Article ] • October 28, 2002

When we feel pain in response to an injury or infection it is the result of messages sent from pain sensors in the outer areas of the body to the brain. These pain sensors – called nociceptors – often lie beneath the skin and detect and signal the presence of tissue-damaging forces or the existence of tissue damage. One particular nociceptor, known as vanilloid receptor-1 (VR1), transmits sensory messages to the brain in response to thermal and painful chemical stimuli and is generally regarded as the major pain sensor.

In conditions such as arthritis or infection, the tissue involved at these sites becomes acidic. While normal human tissue has a neutral pH of approximately 6.5 - 7.5 (similar to water), a condition called tissue acidosis can cause a drop in cellular pH below 6.0 closer to that of household vinegar. When the cellular environment becomes acidic, both VR1 and a second nociceptor - acid sensing ion channels (ASICs) - are activated.

In previous experiments in mice, scientists have found that the activation of VR1 requires extremely severe tissue acidification - pH less than 6.0. This suggests that another pain sensor plays a role in nociception, specifically at pH levels greater than 6.0. Despite experimental data revealing that mouse brain cells lacking ASICs are severely lacking in their responses to acidic stimuli, controversy remains about the function of ASICs in mammals.

In a study reported in the October 21 issue of the Journal of Clinical Investigation (JCI) by Shinya Ugawa and colleagues from the Nagoya City University Medical School, Japan, the authors demonstrated that both VR1 and ASICs are involved in the sensing of acid-evoked pain in humans and that each type of nociceptor mediates this pain perception at very specific pH ranges.

The authors infused solutions of varying pH levels under the skin of the underside of the upper forearm of healthy male volunteers who were subsequently asked to estimate the intensity of the induced pain on a 0-10 scale. To determine which particular nociceptor was activated at each pH level, the authors systematically blocked ASICs-mediated pain perception with the ASICs inhibitor amiloride or VR1-mediated pain perception with the VR1-inhibitor capsazepine and then recorded the intensity of pain indicated by the subject in response to the solutions of various pH. Ugawa and colleagues found that amiloride potently blocked pain induced by solutions with a pH greater than 6.0, while capsazepine did not. At pH levels below 5.0, amiloride was less effective in reducing pain and capsazepine had a partial blocking effect.

These results demonstrated that ASICs, and not VR1, function as acid sensors within the pathophysiologically relevant pH range 6.0 – 7.2, and that the ASICs inhibitor amiloride may be a useful analgesic for the treatment of localized pain within this range.

Post a Comment

Featured Products From the ProHealth Store
Energy NADH™ 12.5mg Mitochondria Ignite™ with NT Factor® Vitamin D3 Extreme™

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products

Article Comments

Be the first to comment on this article!

Post a Comment

Natural Pain Relief Supplements

Featured Products

Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health

Natural Remedies

Health Benefits Are Brewing in Green Tea Health Benefits Are Brewing in Green Tea
Vitamin K-2 – A Key Player in Cardiovascular and Bone Health Vitamin K-2 – A Key Player in Cardiovascular and Bone Health
Natural Relief for Soreness, Pain and Swelling - Putting Out the Fire Natural Relief for Soreness, Pain and Swelling - Putting Out the Fire
The Big Blue Fish that Helps Chase the Blues Away The Big Blue Fish that Helps Chase the Blues Away
Stop Bacteria With Nature's Antibiotics Stop Bacteria With Nature's Antibiotics

ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
Credit Card Processing
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map