ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

10 Fibro-Friendly Foods with a Bonus: Beautiful Skin

Fight Back! Win the War Being Waged Against Your Immune System

Studies Show that Magnesium L-threonate Improves Brain Plasticity, Leading to Direct and Significant...

The role of microbiota and intestinal permeability in the pathophysiology of autoimmune and neuroimm...

Clary Sage Oil May Be Pricey, but Its Benefits Are Priceless

Component of red wine, grapes can help to reduce inflammation, study finds

Poly MVA: A Novel Therapy for Increasing Energy, Repairing DNA, and Promoting Overall Health

Acupressure reduced fatigue in breast cancer survivors

Pumpkin Pie Turmeric Breakfast Smoothie - Vegan + Gluten-Free

Omega-3 fatty acid stops known trigger of lupus

Print Page
Email Article

A Randomized Trial of a Low-Carbohydrate Diet vs Orlistat Plus a Low-Fat Diet for Weight Loss - Source: Archives of Internal Medicine, Jan 25, 2010

  [ 19 votes ]   [ Discuss This Article ]
By William S. Yancy Jr, MD, MHS, et al. • • February 5, 2010

[Note: The ketogenic “Atkins-type” diet used in this trial is high-fat, adequate-protein, low-carb. It is called ketogenic because it forces the body to burn fats rather than carbs for energy. While carbs are converted into glucose for energy, fats are converted by the liver into fatty acids and “ketone bodies,” which replace glucose as an energy source. Orlistat is a prescription drug that acts to limit the digestive tract’s ability to digest and absorb fats consumed in the diet.]

Background:  Two potent weight loss therapies...

• A low-carbohydrate, ketogenic diet (LCKD),

• And orlistat therapy combined with a low-fat diet (O + LFD),

…are available to the public but, to our knowledge, have never been compared.

Methods: Overweight or obese outpatients (n = 146) from the Department of Veterans Affairs primary care clinics in Durham, North Carolina, were randomized to either LCKD instruction (initially, less than 20 grams of carbohydrate daily) or orlistat therapy, 120 mg orally 3 times daily, plus low-fat diet instruction (less than 30% energy from fat, 500 to 1000 kcal/d deficit) delivered at group meetings over 48 weeks.

Main outcome measures were body weight, blood pressure, fasting serum lipid, and glycemic parameters.

Results: The mean age was 52 years and mean body mass index was 39.3 (calculated as weight in kilograms divided by height in meters squared); 72% were men, 55% were black, and 32% had type 2 diabetes mellitus. Of the study participants, 57 of the LCKD group (79%) and 65 of the O + LFD group (88%) completed measurements at 48 weeks.

• Weight loss was similar for the low-carbohydrate, ketogenic diet (expected mean change, –9.5%) and the orlistat plus low-fat diet (–8.5%) (P = .60 for comparison) groups.

• The low-carbohydrate, ketogenic diet had a more beneficial impact than orlistat plus low-fat diet on systolic (–5.9 vs 1.5 mm Hg) and diastolic (–4.5 vs 0.4 mm Hg) blood pressures (P < .001 for both comparisons).

• High-density lipoprotein [so-called ‘good’] cholesterol and triglyceride levels improved similarly within both groups.

• Low-density lipoprotein [so-called ‘bad’] cholesterol levels improved within the orlistat plus low-fat diet group only,

• Whereas glucose, insulin, and hemoglobin A1c levels improved within the low-carbohydrate, ketogenic diet group only; comparisons between groups, however, were not statistically significant.

Conclusion: In a sample of medical outpatients, a low-carbohydrate, ketogenic diet led to similar improvements as orlistat plus low-fat diet for weight, serum lipid, and glycemic parameters and was more effective for lowering blood pressure.

Trial Registration: Identifier: NCT00108524

Source: Archives of Internal Medicine, Jan 25, 2010;170(2):136-145. PMID: 20101008, by Yancy WS, Westman EC, McDuffie JR, Grambow SC, Jeffreys AS, Bolton J, Chalecki A, Oddone EZ. Center for Health Services Research in Primary Care, Department of Veterans Affairs Medical Center; Departments of Medicine and Biostatistics and Bioinformatics, Duke University Medical Center, Durham, North Carolina, USA. [E-mail:]

Post a Comment

Featured Products From the ProHealth Store
Mitochondria Ignite™ with NT Factor® Ultra ATP+, Double Strength Ultra EPA  - Fish Oil

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products

Article Comments

Be the first to comment on this article!

Post a Comment

Natural Pain Relief Supplements

Featured Products

Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%

Natural Remedies

The Surprising Benefits of Probiotics - What You Didn't Know The Surprising Benefits of Probiotics - What You Didn't Know
"It's Not Easy Being Green" - But It Is Healthy
Secret Nutrient for Radiant Skin Secret Nutrient for Radiant Skin
The Brain Boosting and Fatigue Fighting B-12 The Brain Boosting and Fatigue Fighting B-12
A Hard-Working Molecule that May Help Ease Pain & Brighten Mood A Hard-Working Molecule that May Help Ease Pain & Brighten Mood

ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
Credit Card Processing
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map