Activate Now
 
ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Patient Insights into the Design of Technology to Support a Strengths-Based Approach to Health Care.

SURVEY: Weight Management & Chronic Illness

Japanese green tea consumers have reduced risk of dementia

Do Nothing, Accomplish Everything! The Connection Between Breathing and Healing

Meet the ProHealth Editors

Best Herbs to Help With Insomnia

Choline: Why You Should Eat Your Egg Yolks and Take Krill

Calcium, vitamin D supplementation associated improved stroke recovery

Acupressure reduced fatigue in breast cancer survivors

More positive evidence for melatonin in breast cancer battle

 
Print Page
Email Article

European multicenter randomized double-blind placebo-control mono-therapy clinical trial of [Savella] milnacipran in the treatment of fibromyalgia – Source: Journal of Rheumatology, Feb 15, 2010

  [ 16 votes ]   [ 2 Comments ]
By Jaime C Branco, Yves Mainguy, et al. • www.ProHealth.com • February 20, 2010


Objective: This randomized, double-blind, placebo-controlled, multicenter study investigated the efficacy and safety of milnacipran [brand name Savella] in the treatment of fibromyalgia (FM) in a European population.

Methods: Outpatients diagnosed with FM according to 1990 American College of Rheumatology criteria (N = 884) were randomized to placebo (n = 449) or milnacipran 200 mg/day (n = 435) for 17 weeks (4-week dose escalation, 12-week stable dose, 9-day down-titration), followed by a 2-week posttreatment period.

The primary efficacy criterion was a 2-measure composite responder analysis requiring patients to achieve simultaneous improvements in pain (>/= 30% improvement from baseline in visual analog scale, 24-hour morning recall) and a rating of "very much" or "much" improved on the Patient Global Impression of Change scale.

If responder analysis was positive, Fibromyalgia Impact Questionnaire (FIQ) was included as an additional key primary efficacy measure.

Results:

• At the end of the stable dose period (Week 16), milnacipran 200 mg/day showed significant improvements from baseline relative to placebo in the 2-measure composite responder criteria (p = 0.0003) and FIQ total score (p = 0.015).

• Significant improvements were also observed in multiple secondary efficacy endpoints, including Short-Form 36 Health Survey (SF-36) Physical Component Summary (p = 0.025), SF-36 Mental Component Summary (p = 0.007), Multidimensional Fatigue Inventory (p = 0.006), and Multiple Ability Self-Report Questionnaire (p = 0.041).

• Milnacipran was safe and well tolerated; nausea, hyperhidrosis [excessive sweating], and headache were the most common adverse events.

Conclusion: . Milnacipran is an effective and safe treatment for pain and other predominant symptoms of FM

Registered as trial no. NCT00436033.

Source: Journal of Rheumatology, Feb 15, 2010. PMID: 20156949, by Branco JC, Zachrisson O, Perrot S, Mainguy Y.  Faculdade Ciencias Medicas, Universidade Nova de Lisboa, Servico de Reumatologia, CHLO, EPE-Hospital Egas Moniz, Lisboa, Portugal; Gottfries Clinic AB, Molndal, Sweden; Service de Medecine Interne, Hotel Dieu Hospital, Paris Descartes University, Paris; Pierre Fabre Médicament, Boulogne, France. [Email: yves.mainguy@pierre-fabre.com]





Post a Comment

Featured Products From the ProHealth Store
Ultra EPA  - Fish Oil FibroSleep™ Ultra ATP+, Double Strength

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments Post a Comment

SAVELLA
Posted by: toots2
Feb 24, 2010
The side effect of excessive sweating that comes with taking Savella is something I can no unfortunately no longer tolerate which is sad because Savella taken as directed works so well on the pain. I have not had to completely give up the Savella but have cut my dosage in half which means it does not take care of the pain as well but well enough I believe to still help. I wish somethinig could be done about the sweating as it seems to affect so many of us that take Savella and because taken at full strength it works better than any narcotic pain medication I have ever taken. Just my thoughts on this wonderful new medication. Suzanne
Reply Reply

Savella
Posted by: cpacos
Feb 25, 2010
This medicine has been such a blessing! It controlls the pain pretty good, but the energy that I am experiencing now is so wonderful! I can finally keep up with life, no more afternoon naps! I can have a full time job, and come home and cook dinner! This has been so wonderful!I have been on it for almost 10 months.
Reply Reply
 
Natural Pain Relief Supplements

Featured Products

Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils

Natural Remedies

D-ficient? Health Risks You Need to Know About D-ficient? Health Risks You Need to Know About
Nutrients to Combat the Modern Stress Epidemic Nutrients to Combat the Modern Stress Epidemic
Complete and Natural Menopause Relief Complete and Natural Menopause Relief
Astaxanthin - A Little-Known but Power-Packed Nutrient Astaxanthin - A Little-Known but Power-Packed Nutrient
Health Benefits Are Brewing in Green Tea Health Benefits Are Brewing in Green Tea

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE AND SAVE 15% NOW*
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map