ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Can Autoimmune Conditions be Reversed? Researchers Make a Surprising Discovery

How One Tiny Molecule Turned into One Huge Health Breakthrough

Acupuncture boosts effectiveness of standard medical care for chronic pain, depression

Research on Astaxanthin Demonstrates Significant Whole Body Benefits

Humans have three times more brown body fat

Nutrients Boost Stem Cell Function

B12 Proven Essential for Every Cell

Soy isoflavones may benefit breast cancer patients

Dietary prebiotics improve sleep, buffer impacts of stress, says study

How B Vitamins Improve Brain Health, Cognition, Psychiatric Problems and Mood Disorders

 
Print Page
Email Article

European multicenter randomized double-blind placebo-control mono-therapy clinical trial of [Savella] milnacipran in the treatment of fibromyalgia – Source: Journal of Rheumatology, Feb 15, 2010

  [ 16 votes ]   [ 2 Comments ]
By Jaime C Branco, Yves Mainguy, et al. • www.ProHealth.com • February 20, 2010


Objective: This randomized, double-blind, placebo-controlled, multicenter study investigated the efficacy and safety of milnacipran [brand name Savella] in the treatment of fibromyalgia (FM) in a European population.

Methods: Outpatients diagnosed with FM according to 1990 American College of Rheumatology criteria (N = 884) were randomized to placebo (n = 449) or milnacipran 200 mg/day (n = 435) for 17 weeks (4-week dose escalation, 12-week stable dose, 9-day down-titration), followed by a 2-week posttreatment period.

The primary efficacy criterion was a 2-measure composite responder analysis requiring patients to achieve simultaneous improvements in pain (>/= 30% improvement from baseline in visual analog scale, 24-hour morning recall) and a rating of "very much" or "much" improved on the Patient Global Impression of Change scale.

If responder analysis was positive, Fibromyalgia Impact Questionnaire (FIQ) was included as an additional key primary efficacy measure.

Results:

• At the end of the stable dose period (Week 16), milnacipran 200 mg/day showed significant improvements from baseline relative to placebo in the 2-measure composite responder criteria (p = 0.0003) and FIQ total score (p = 0.015).

• Significant improvements were also observed in multiple secondary efficacy endpoints, including Short-Form 36 Health Survey (SF-36) Physical Component Summary (p = 0.025), SF-36 Mental Component Summary (p = 0.007), Multidimensional Fatigue Inventory (p = 0.006), and Multiple Ability Self-Report Questionnaire (p = 0.041).

• Milnacipran was safe and well tolerated; nausea, hyperhidrosis [excessive sweating], and headache were the most common adverse events.

Conclusion: . Milnacipran is an effective and safe treatment for pain and other predominant symptoms of FM

Registered as trial no. NCT00436033.

Source: Journal of Rheumatology, Feb 15, 2010. PMID: 20156949, by Branco JC, Zachrisson O, Perrot S, Mainguy Y.  Faculdade Ciencias Medicas, Universidade Nova de Lisboa, Servico de Reumatologia, CHLO, EPE-Hospital Egas Moniz, Lisboa, Portugal; Gottfries Clinic AB, Molndal, Sweden; Service de Medecine Interne, Hotel Dieu Hospital, Paris Descartes University, Paris; Pierre Fabre Médicament, Boulogne, France. [Email: yves.mainguy@pierre-fabre.com]





Post a Comment

Featured Products From the ProHealth Store
Vitamin D3 Extreme™ Ultra EPA  - Fish Oil FibroSleep™

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments Post a Comment

SAVELLA
Posted by: toots2
Feb 24, 2010
The side effect of excessive sweating that comes with taking Savella is something I can no unfortunately no longer tolerate which is sad because Savella taken as directed works so well on the pain. I have not had to completely give up the Savella but have cut my dosage in half which means it does not take care of the pain as well but well enough I believe to still help. I wish somethinig could be done about the sweating as it seems to affect so many of us that take Savella and because taken at full strength it works better than any narcotic pain medication I have ever taken. Just my thoughts on this wonderful new medication. Suzanne
Reply Reply

Savella
Posted by: cpacos
Feb 25, 2010
This medicine has been such a blessing! It controlls the pain pretty good, but the energy that I am experiencing now is so wonderful! I can finally keep up with life, no more afternoon naps! I can have a full time job, and come home and cook dinner! This has been so wonderful!I have been on it for almost 10 months.
Reply Reply
 
NAD+ Ignite with Niagen

Featured Products

Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid

Natural Remedies

Probiotic Mint Promotes Healthy Gums & Teeth, Freshens Breath and Whitens Teeth Probiotic Mint Promotes Healthy Gums & Teeth, Freshens Breath and Whitens Teeth
Quercetin: Natural Support for Allergy & Inflammation Relief and More Quercetin: Natural Support for Allergy & Inflammation Relief and More
Reversing Neurodegeneration with a New Magnesium Compound Reversing Neurodegeneration with a New Magnesium Compound
Live Without Anxiety or Stress Live Without Anxiety or Stress
Vitamin K-2 – A Key Player in Cardiovascular and Bone Health Vitamin K-2 – A Key Player in Cardiovascular and Bone Health

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map