New research shows that a high level of C-reactive protein (CRP) - a marker for sustained inflammation and a known cardiovascular disease risk factor - is also associated with brain changes that are linked to problems with executive thinking skills (planning, decisionmaking, deciding appropriate behavior).
The study (“Serum C-reactive protein is linked to cerebral microstructural integrity and cognitive function”) was published Mar 30, 2010 in the journal Neurology®.
For the study, scientists examined 447 stroke and dementia-free people with an average age of 63.
Participants underwent MRI brain scans such as diffusion tensor imaging (DTI), a technique that measures water molecule movements in the brain. They also completed tests that measured verbal memory, word fluency and executive function.
• The study found that higher levels of CRP led to worse performance in executive function.
• Higher levels of the protein also affected the frontal lobe of the brain, where some motor functions take place. Motor skills, however, were not measured in the study.
• Other areas of cognition, such as memory and language skills, showed no association with CRP.
Overall, the average time to complete a test of executive function was 85 seconds.
• Those with the highest levels of CRP took an average of seven seconds longer to complete the test than those with the lowest levels of the protein.
• The brain changes measured with DTI were equivalent to 12 years of aging for those with the highest levels of CRP compared to those with the lowest levels.
"The use of aspirin and statin [cholesterol lowering] drugs as well as physical activity and controlling weight can help lower CRP levels in the body, but our analyses did not consider whether therapy would be effective or not," said study author Heike Wersching, MD, with the University of Münster in Germany.
[Note: another recent study demonstrates a significant direct relationship between higher omega-3 fatty acid (fish oil) intake and lower serum C-reactive protein.]
Source: American Academy of Neurology, Mar 29, 2010