ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Delayed diagnosis of Lyme disease has devastating effect on patients

Association of lyme disease and schizoaffective disorder, bipolar type: Is it inflammation mediated?

Adapt to Stress Naturally with These Power Herbs

A short-term Borrelia burgdorferi infection model identifies tissue tropisms and bloodstream surviva...

Curcumin Made 65X More Bioavailable - Modern Take on a "Golden" Spice Busts Brain Fog, Joint & Body ...

Why So Many Arthritis Sufferers Fail to Find Relief

Discovering Coffee's Unique Health Benefits

Safely Manage Joint Inflammation: Curcumin

Bay Area Lyme Foundation Awards Grant to Harvard Medical School Researchers for Development of an Ac...

New Research Substantiates the Anti-Aging Properties of DHEA

 
Print Page
Email Article

JAMA Reports Gabapentin [Neurontin] and Certain Other Anticonvulsant Drugs May Be Associated with Increased Suicide Risk

  [ 43 votes ]   [ 3 Comments ]
www.ProHealth.com • April 14, 2010


An analysis of prescription and clinical claims data suggests that the use of certain anticonvulsant medications may be associated with an increased risk of suicide, attempted suicide or violent death, according to a study in the April 14 issue of JAMA (“Anticonvulsant medications and the risk of suicide, attempted suicide, or violent death.”).  

Anticonvulsant medications are a primary therapeutic approach for patients with epilepsy, but labeled indications also include bipolar disorder, mania, neuralgia (sudden occurrences of short, sharp pains along a nerve), migraine, and neuropathic pain (e.g., shingles pain) [and occasionally off label for fibromyalgia].

“The wide range of indications and common use of anticonvulsants in patients with or without psychiatric comorbidities make their safety an issue of great relevance,” the authors write. “In 2008, the U.S. Food and Drug Administration mandated warning labeling for anticonvulsant medications regarding the increased risk of suicidal thoughts and behaviors. The decision was based on a meta-analysis not sufficiently large to investigate individual drugs.”

Elisabetta Patorno, MD, MPH, of Brigham and Women's Hospital and Harvard Medical School, Boston, and colleagues evaluated whether there was an increased risk of attempted or completed suicide, and combined suicidal acts or violent death associated with a range of individual anticonvulsant medications and within patient subgroups.

The researchers analyzed data for 14 states from the HealthCore Integrated Research Database (includes information on filled prescriptions and clinical encounters) for patients 15 years and older who began taking an anticonvulsant between July 2001 and December 2006.

The study identified 827 suicidal acts (801 attempted suicides and 26 completed suicides) and an additional 41 violent deaths (868 combined suicidal acts or violent deaths) in 297,620 new episodes of treatment with an anticonvulsant.

The researchers found that the risk of suicidal acts was increased [1.5 to 2 times as much] for
• Gabapentin [brand name Neurontin],
• Lamotrigine [Lamictal],
• Oxcarbazepine [Trileptal],
• Tiagabine [Gabitril],
• And valproate [Depacon],
…compared with topiramate [Topamax].

“The analyses including violent death produced similar results. Gabapentin users had increased [about twice as much] risk in subgroups of younger and older patients, patients with mood disorders, and patients with epilepsy or seizure when compared with carbamazepine [Tegretol],” the authors write.

“This exploratory analysis contributes to the understanding of the complex and little-understood relationship between anticonvulsant medication use and suicide risk.”

Source: American Medical Association news release, April 14, 2010



Please Discuss This Article:   Post a Comment 

What about Lyrica?
Posted by: airihannah
Apr 21, 2010
I didn't see Lyrica mentioned in this article, but isn't it a derivative form of Gabapentin or in some way related pretty closely? I've been taking Lyrica for several years now and I know that I'm suffering from more depression and have had suicidal thoughts that I haven't had before. In addition I tried to use Chantix to stop smoking and had an extreme psychotic episode on that.... I would be nice to know, if it's even possible to predict, whether the type of reaction that I had to Chantix is a predictor or indicator of similar reactions to other medications. Either way, I would like to find out how Lyrica fits into the study and whether it's similar enough to the drugs that were mentioned to be included in the list of drugs that could be of concern in higher risk of suicide. Lori Hamilton www.designumbers.com
Reply Reply

 
Chantix
Posted by: evilgalblues
Apr 22, 2010
My FIL wanted to try Chantix but was told he was contra-indicated because he had a psychotic break on bupropion. They said the same thing would happen again. He has to be really careful with antidepressants now.

 


Lyrica
Posted by: madeintheuk
Apr 21, 2010
I took Lyrica for six months for FM and it worked reasonably well. I had a number of side effects. When I came off Lyrica I had extreme depression, suicidal thoughts, and ended up in psych ward - terrible experience. I am now on gabapentin and all is ok so far. Its all rather scary though.
Reply Reply
 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Vitamins and Supplements

Featured Products

Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function

Natural Remedies

Olea25 Olive Hydroxytyrosol Hits Astonishing 68,000+ ORAC Antioxidant Value Olea25 Olive Hydroxytyrosol Hits Astonishing 68,000+ ORAC Antioxidant Value
Green Coffee Extract: Unique Obesity Intervention Green Coffee Extract: Unique Obesity Intervention
Health Benefits Are Brewing in Green Tea Health Benefits Are Brewing in Green Tea
Can Glycine + Amino Acids Be the Secret to Deep, Rejuvenating Sleep? Can Glycine + Amino Acids Be the Secret to Deep, Rejuvenating Sleep?
The Brain Boosting and Fatigue Fighting B-12 The Brain Boosting and Fatigue Fighting B-12

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia Diagnosis
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS Diagnosis
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE  |  PRIVACY
CONTACT US
LIBRARY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing