Activate Now
 
ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Patient Insights into the Design of Technology to Support a Strengths-Based Approach to Health Care.

Greater intake of dietary omega-3 fatty acids associated with lower risk of diabetic retinopathy

SURVEY: Weight Management & Chronic Illness

Japanese green tea consumers have reduced risk of dementia

Researchers find herpes strain in the nervous system

Do Nothing, Accomplish Everything! The Connection Between Breathing and Healing

Nature Heals

Best Herbs to Help With Insomnia

Choline: Why You Should Eat Your Egg Yolks and Take Krill

Calcium, vitamin D supplementation associated improved stroke recovery

 
Print Page
Email Article

Serotonin-Related Genetic IBS ‘Perps’ Discovered at Mayo

  [ 25 votes ]   [ Discuss This Article ]
www.ProHealth.com • May 4, 2010


Their “genetic dragnet” identified previously unknown culprits, some distinct for constipation, some for diarrhea.

Most people associate serotonin with brain neurology, but over 95% of the body's serotonin occurs in the gastrointestinal tract, which has a complex neuronal circuit that has been called "the second brain" of the body.

Now a Mayo Clinic research team has identified a number of genetic variants in serotonin genes that impact irritable bowel syndrome or IBS. The findings were presented May 4 at Digestive Disease Week 2010 in New Orleans.

IBS is one of the most common chronic disorders of the digestive tract. It can cause years of discomfort or pain and altered bowel habits, limit a person's personal and professional life, and cost millions nationally in medical costs and loss of time from work or school.

"It's been known that some drugs that alter serotonin levels in the body also have an effect on motility, thus prompting IBS-like symptoms, but the genetic and molecular mechanism for IBS was unclear," says Yuri Saito, MD, Mayo Clinic gastroenterologist and presenter of the study. "A number of studies had looked at a few polymorphisms and a handful of genes."

The Mayo team used high throughput technology to study nearly 400 tagged single-nucleotide polymorphisms (SNPs) in over 20 serotonin-related genes.

Using a familiar analogy, Dr. Saito says, "Rather than sending out a few patrol cars to look for culprits by rounding up 'the usual suspects,' we launched a genetic dragnet that took an objective, unbiased look at a broader range of possibilities." They found a number of previously unknown IBS associations.

The conclusion:

• Many more serotonin-related SNPs were implicated in IBS than first thought.

• The implicated genes relate to serotonin synthesis, metabolism and receptors.

The researchers also found:

• IBS may be caused by multiple genes - not just one or a few,

• And there may be distinct as well as overlapping molecular mechanisms that cause diarrhea and constipation, two major symptoms of IBS.

The findings offer future researchers specific targets for drug development or other therapies to combat IBS.

Other Mayo researchers involved in the study were Joseph Larson; Elizabeth Atkinson; Euijung Ryu, PhD; Ann Almazar-Elder; Nicholas Talley, MD, PhD; Michael Camilleri, MD; and Gloria Petersen, PhD.

The study was supported by the National Institutes of Health.

Source: Mayo Clinic (Minnesota) news release May 4, 2010




Post a Comment

Featured Products From the ProHealth Store
Mitochondria Ignite™ with NT Factor® Energy NADH™ 12.5mg FibroSleep™

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
Natural Pain Relief Supplements

Featured Products

Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health

Natural Remedies

The Crucial Role CoQ10 Plays in Fibromyalgia and ME/CFS The Crucial Role CoQ10 Plays in Fibromyalgia and ME/CFS
Can Glycine + Amino Acids Be the Secret to Deep, Rejuvenating Sleep? Can Glycine + Amino Acids Be the Secret to Deep, Rejuvenating Sleep?
Research Links Green Tea to Weight Loss Research Links Green Tea to Weight Loss
Safely Burn Away Body Fat Safely Burn Away Body Fat
More Weight Loss than Any Other Discovery in Supplement History More Weight Loss than Any Other Discovery in Supplement History

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE AND SAVE 15% NOW*
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map