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Clinical Uses of Melatonin: Evaluation of Human Trials – Source: Current Medicinal Chemistry, Apr 28, 2010

  [ 93 votes ]   [ 3 Comments ]
By EJ Sanchez-Barcelo, et al. • • May 6, 2010

During the last 20 years, numerous clinical trials have examined the therapeutic usefulness of melatonin in different fields of medicine. The objective of this article is to review, in depth, the science regarding clinical trials performed to date.

The efficacy of melatonin has been assessed as a treatment of ocular diseases, blood diseases, gastrointestinal tract diseases, cardiovascular diseases, diabetes, rheumatoid arthritis, fibromyalgia, chronic fatigue syndrome, infectious diseases, neurological diseases, sleep disturbances, aging and depression.

Melatonin has been also used as a complementary treatment in anesthesia, hemodialysis, in vitro fertilization and neonatal care.

The conclusion of the current review is that:

• The use of melatonin as an adjuvant therapy seems to be well founded for:
- Macular degeneration,
- Glaucoma,
- Protection of the gastric mucosa [stomach lining],
- Irritable bowel syndrome,
- Arterial hypertension,
- Diabetes,
- Side effects of chemotherapy and radiation in cancer patients or hemodialysis in patients with renal insufficiency,
- And, especially, for sleep disorders of circadian etiology (jet lag, delayed sleep phase syndrome, sleep deterioration associated with aging, etc.) as well as in those related with neurological degenerative diseases (Alzheimer’s, etc.) or Smith-Magenis syndrome.

• The utility of melatonin in anesthetic procedures has been also confirmed.

• More clinical studies are required to clarify whether, as the preliminary data suggest, melatonin is useful for treatment of:
- Fibromyalgia,
- Chronic fatigue syndrome [ME/CFS],
- Infectious diseases,
- Neoplasias or neonatal care.

• Preliminary data regarding the utility of melatonin in the treatment of ulcerative colitis, Crohn's disease, rheumatoid arthritis are either ambiguous or negative.

• Although in a few cases melatonin seems to aggravate some conditions, the vast majority of studies document the very low toxicity of melatonin over a wide range of doses.

Source: Current Medicinal Chemistry, Apr 28, 2010. PMID: 20423309, Sánchez-Barceló EJ, Mediavilla MD, Tan DX, Reiter RJ. Department of Physiology & Pharmacology, School of Medicine, University of Cantabria, Santander, Spain. [Email:]

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Article Comments Post a Comment

Melatonin & Fibromyalgia
Posted by: trobaud
May 19, 2010
I have Fibromyalgia & have taken Melatonin the past 5yrs until about 2 months ago. I then began to take ProHealth's FibroSleep which contains melatonin & really works well for me. Deb T.
Reply Reply

How did Mltn help you?
Posted by: IanH
May 26, 2010
If you don't mind me asking. How did Melatonin help? Less waking up during the night? More refreshed in the morning? Less pain in the morning? Less stiffness in the morning? Fell asleep more quickly? Did it help in any other way? Particularly during the day. What dose did you take? Was your dosage night only or did take some during the day? Thanks for help Ian Hodgson
Reply Reply

Posted by: neenyteeny
Sep 25, 2010
I tried melatonin for the first time a few months ago. It did help me get to sleep faster, but the only side affect the four times I've taken it were how exceptionally weird my dreams were. But I felt rested the next day. I do recommend if you take it, to at least allow 7-8 hrs of uninterrupted sleep.
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