ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

On-and-off fasting helps fight obesity, study finds

Can Pomegranates Slow Aging?

Calorie restriction promotes longevity through effects on mitochondrial network

Eat Your Prunes

Discover Why Ashwagandha Can Be Used for Stress and Anxiety

Lower magnesium levels linked with increased mortality risk during up to 40 years of follow-up

A spoonful of oil: Fats and oils help to unlock full nutritional benefits of veggies, study suggests

Higher resveratrol dose linked to lower glucose levels in type 2 diabetics

How Can You Benefit From Vitamin B12?

Drug can dramatically reduce weight of people with obesity

 
Print Page
Email Article

Effect of adding milnacipran to pregabalin in the management of fibromyalgia: A randomized, open-label, controlled study – Source: Presentation at American Pain Society Annual Meeting, May 6-8 2010

  [ 58 votes ]   [ Discuss This Article ]
By Mildred Farmer, et al. • www.ProHealth.com • May 19, 2010


Clinical practice guidelines for treatment of fibromyalgia (FM) emphasize the role of pharmacologic interventions that address multiple symptoms, such as pain, fatigue, and sleep disturbance. Patients with FM may benefit from a combination of medications with complementary mechanisms of action that could yield additive or synergistic effects.

A rational combination therapy approach would be:

• Milnacipran [brand name Savella®], a dual reuptake inhibitor thought to augment norepinephrine and serotonin neurotransmitter signaling in descending pain modulatory neurons,

• Plus pregabalin [brand name Lyrica®), which may inhibit nociceptive signaling in ascending fibers through voltage-gated calcium channels.

This randomized, open-label, controlled study evaluated the efficacy and tolerability of milnacipran 50 mg BID when added to pregabalin 150 mg BID or 225 mg BID in FM patients who had an incomplete response to pregabalin during a 4- to 12-week open-label run-in phase.

Pregabalin incomplete responders (defined as patients with weekly recall VAS pain score 40 or more and 90 or less [0 to 100 scale], Patient Global Impression of Severity score 4 or more [moderately ill], and Patient Global Impression of Change [PGIC] score 3 or more [minimally improved]) were randomized to either pregabalin alone (n=179) or milnacipran with pregabalin (n=184) for 11 weeks.

The primary endpoint was an ITT responder analysis, with responders defined as patients reporting a PGIC score of “1” or “2” at endpoint.

• Significantly more patients receiving combination therapy were PGIC responders than patients receiving pregabalin alone.

• The addition of milnacipran to pregabalin also resulted in significantly greater reductions in mean weekly recall VAS pain scores.

• Approximately one-third of patients discontinued the study,

• With fewer patients discontinuing from the milnacipran with pregabalin combination group than pregabalin alone.

This was the first randomized controlled study to demonstrate that adding milnacipran to pregabalin therapy was tolerable and effective in improving global status and reducing pain in patients with FM. (Supported by Forest Laboratories, Inc. and Cypress Bioscience, Inc.)

Source: Presentation (Abstract #215) at American Pain Society Annual Meeting, May 6-8, 2010. By Farmer M, Dayani N, Trugman J, Wang Y, Gendreau R. Forest Research Institute and Cypress Bioscience, Inc., Jersey City, New Jersey and San Diego, California, USA.





Post a Comment

Featured Products From the ProHealth Store
FibroSleep™ Vitamin D3 Extreme™ Energy NADH™ 12.5mg


Article Comments



Be the first to comment on this article!

Post a Comment


 
Optimized Curcumin Longvida with Omega-3

Featured Products

FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength

Natural Remedies

Strontium - The Missing Mineral for Strong Bones Strontium - The Missing Mineral for Strong Bones
Mitochondria-Booster NIAGEN® Shows Promise in First Human Clinical Trial Mitochondria-Booster NIAGEN® Shows Promise in First Human Clinical Trial
Energy Breakthrough - One Fibromyalgia Patient’s Fortuitous Discovery Energy Breakthrough - One Fibromyalgia Patient’s Fortuitous Discovery
The Guaifenesin Story: A centuries-old bark extract used for clearing the airways – now key to a popular FM symptom-reversal protocol The Guaifenesin Story: A centuries-old bark extract used for clearing the airways – now key to a popular FM symptom-reversal protocol
Live Without Anxiety or Stress Live Without Anxiety or Stress

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map