ProHealth health Vitamin and Natural Supplement Store and Health
Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|
|
 
Print Page
Email Article

Subset-directed antiviral treatment of 142 herpesvirus patients with chronic fatigue syndrome - Source: Virus Adaptation and Treatment, May 2010

  [ 71 votes ]   [ 2 Comments ]
By A Martin Lerner, et al. • www.ProHealth.com • May 24, 2010

previous article next article

[Note: To read the free full text of this important article on the results of long-term antiviral treatment of ME/CFS patients, click here.

Purpose: We hypothesized that chronic fatigue syndrome (CFS) may be caused by single or multiple Epstein–Barr virus (EBV), cytomegalovirus (HCMV), or human herpesvirus 6 (HHV6) infection.

To determine if CFS life-altering fatigue and associated findings including muscle aches, tachycardia at rest, chest aches, left ventricular dysfunction, syncope, and elevated herpesvirus serum antibody titers are reversed by long-term subset-directed valacyclovir and/or valganciclovir.

Patients and methods:
Data were collected at physician visits every 4–6 weeks from 142 CFS patients at one clinic from 2001 to 2007. To be included in this study, patients had to be followed for at least six months. The data captured included over 7,000 patient visits and over 35,000 fields of information. Severity of fatigue was monitored by a validated Energy Index Point Score® (EIPS®).

Baseline and follow-up serum antibody titers to EBV, HCMV, and HHV6, as well as coinfections with Borrelia burgdorferi, Anaplasma phagocytophila, Babesia microti, and antistreptolysin O [a marker of Group A streptococcus infection], 24-hour ECG Holter monitors, 2D echocardiograms, cardiac dynamic studies, symptoms, and toxicity were captured and monitored.

International criteria for CFS plus a specifically designed CFS diagnostic panel were used.

Results and conclusions:


• The Group A herpesvirus CFS patients (no coinfections) returned to a near-normal to normal life (P = 0.0001). [Probability of result occuring by chance 1 in 10,000.]
-  The long-term EIPS value increased (primary endpoint, P < 0.0001) with subset-directed long-term valacyclovir and/or valganciclovir therapy.
-  Secondary endpoints (cardiac, immunologic, and neurocognitive abnormalities) improved or disappeared.

• Group B CFS patients (herpesvirus plus coinfections) continued to have CFS.

Source: Virus Adaptation and Treatment, May 2010;2010(2). Lerner AM, Begaj S, Fitzgerald JT, Gill K, Gill C, Edington J. Department of Medicine, William Beaumont Hospital, Royal Oak; Wayne State University School of Medicine, Detroit; Department of Medical Education, University of Michigan Medical School, Ann Arbor; Dr A Martin Lerner Chronic Fatigue Syndrome Foundation, Beverly Hills, Michigan, USA. [Email: amartinlerner@yahoo.com]

[To read ME/CFS science reporter Cort Johnson's very informative article on this research and his interview with Dr. Lerner, click here.]



previous article
  Rating 3.5 (71 votes) next article




DISCUSS THIS ARTICLE   (2 existing comments) Post a Comment 


Antiviral treatment
Posted by: KerryK
May 24, 2010
This should be huge news! It seems to also confirm the notion of multiple causes.
Reply Reply

 
More evidence of an immunological dysfunction - multipathogen
Posted by: IanH
May 26, 2010
These results are a bit of surprise in a way because previous studies looking at the herpes viruses were unclear. It does lend more weight to the theory that CFS is caused by an altered immune state by the existence of one or more pathogens which keep the immune system "activated". That is, it is not the pathogens themselves which is causing CFS but the immunological state as suggested in the recent paper by Broderick, Klimas et al showing how different "cytokine networks" are imbalanced. This theory also leaves open the possibility that some forms of CFS may be caused by toxins either alone or in conjunction with viral pathogens.

 

 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Your Next Order

Featured Products
Omega 3-6-9 Omega 3-6-9
All three EFAs in one convenient form
Natural Resveratrol Natural Resveratrol
Powerful Antioxidant Support + Positive Anti-aging Effects
Vitamin D3 5000 IU Vitamin D3 5000 IU
Give your body a boost with the sunshine vitamin
OsteoTec™ UC-II® OsteoTec™ UC-II®
A True Breakthrough in Joint health
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength

Most Viewed Articles
What's the Hidden Cause Behind YOUR Fibromyalgia Flares? [more]

VIDEO: IACFS/ME Conference - Summary of Research by Dr. Komaroff [more]

How to Limit or Minimize Your Fibromyalgia Flare [more]

Mitochondrial Dysfunction, Post-Exertional Malaise and CFS/ME [more]

The Devil Is In The Details – A Herpes Simplex Virus Inquiry For Fibromyalgia and Chronic Fatigue Sy... [more]

Review of Nutritional Supplements Used for ME/CFS and FM [more]

Sympathetic Nervous System Dysfunction in FIbromyalgia and Overlapping Conditions [more]

FREE: Stop Feeding Yourself PAIN Guide [more]

Sympathetic nervous system dysfunction in fibromyalgia, chronic fatigue syndrome, irritable bowel sy... [more]

EBV I: A Deficient Immune Response, Increased Levels of Epstein-Barr Virus Opens Up EBV Question in ... [more]


FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia 101
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS 101
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE
CONTACT US
PRIVACY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing