ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Friendly User's Guide for the Timing of Nutritional Supplements

The Health Benefits of Manuka Honey

Increase Your Magnesium Intake

Vitamin D supplementation could ease IBS symptoms

Top Tips to Boost Your Immunity

11 Amazing Health Benefits of Using Baking Soda

Nicotinamide riboside shows promise for treatment of Alzheimer’s disease

Exercise, calcium, vitamin D, and other factors linked with fewer injurious falls

Vitamin D3 Is a Powerhouse for Your Heart

Curcumin Supplementation May Impart Long-Term Cognitive Benefits

 
Print Page
Email Article

Effective Osteoarthritis Drug With Fewer GI Side Effects Than NSAIDs (Advil, Nuprin, etc.)

  [ Not Yet Rated ]   [ Discuss This Article ]
By News Release • www.ProHealth.com • January 19, 2000


CHICAGO, IL -- Dr. Michael J. Langman, M.D., from University of Birmingham, England, and colleagues compared the incidence of GI side-effects of the drug rofecoxib to NSAIDs for the treatment of patients with osteoarthritis. Rofecoxib, like celecoxib, is an anti-inflammatory agent that inhibits the production of the COX-2 enzymes while allowing the COX-1 enzymes. The authors found that when compared to NSAIDs, rofecoxib was associated with a significantly lower incidence of GI toxic effects, such as upper GI tract perforations, symptomatic gastroduodenal ulcers and upper GI tract bleeding (PUBs-perforations, ulcers and bleeding). The cumulative incidence of PUBs over 12 months was significantly lower with rofecoxib vs. NSAIDs (1.3 percent vs. 1.8 percent).

The cumulative incidence of dyspeptic GI adverse experiences was also lower with rofecoxib (23.5 percent) compared to NSAIDs (25.5 percent) over six months, after which incidence rates converged.

The authors analyzed the results of eight randomized, double-blind clinical trials of rofecoxib (5,435 patients overall). According to the authors, "PUBs are rare and large numbers of patients are necessary to evaluate the rate of incidence with precision."

"Our analysis shows that COX-2 specific inhibition with rofecoxib was associated with a significantly lower risk of PUBs relative to NSAIDs," the authors write. "These findings are consistent with the results of studies of intestinal permeability, fecal red blood cell loss, and upper GI endoscopy with rofecoxib and indicate that risks of GI toxic effects associated with NSAIDs can be reduced by COX-2 specific inhibition." (JAMA. 1999;282:1921-1928)

Source: The Journal of the American Medical Association (JAMA)



Post a Comment

Featured Products From the ProHealth Store
Optimized Curcumin Longvida® Energy NADH™ 12.5mg FibroSleep™


Article Comments



Be the first to comment on this article!

Post a Comment


 
Optimized Curcumin Longvida with Omega-3

Featured Products

Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get Energized with Malic Acid & Magnesium
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function

Natural Remedies

Safely Burn Away Body Fat Safely Burn Away Body Fat
Sleep Like a Baby in Nature's Cradle Sleep Like a Baby in Nature's Cradle
The Super Antioxidant for Brain, Joint and Heart Health The Super Antioxidant for Brain, Joint and Heart Health
Cocoa's Polyphenol Riches - All the Health Benefits without the Sugar, Calories or Guilt Cocoa's Polyphenol Riches - All the Health Benefits without the Sugar, Calories or Guilt
Help for Soreness and Swelling: What Do Silkworms Have to Do With It? Help for Soreness and Swelling: What Do Silkworms Have to Do With It?

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2018 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map