Background: Phosphatidylserine (PS) may have beneficial effects on cognitive functions. We evaluated the efficacy of a novel preparation of phosphatidylserine containing omega-3 long-chain polyunsaturated fatty acids [docosa/hexaenoic acid (DHA), obtained from fish oil] attached to its backbone (PS-DHA) in non-demented elderly with memory complaints.
Methods: 157 participants were randomized to receive either PS-DHA or placebo for 15 weeks. Efficacy measures, assessed at baseline and endpoint, included:
• The Rey Auditory Verbal Learning Test,
• Rey Complex Figure Test,
• And a computerized cognitive battery.
Clinicians' Global Impression of Change was assessed following 7 and 15 weeks of treatment.
Results: 131 participants completed the study, although 9 were excluded from the efficacy analysis due to protocol violation.
• At endpoint, verbal immediate recall was significantly improved in the PS-DHA group compared to the placebo group.
• Post-hoc analysis revealed that a subset of participants with relatively good cognitive performance at baseline had significant treatment-associated improvements in:
- Immediate and delayed verbal recall,
- Learning abilities,
- And time to copy complex figure.
These favorable results were further supported by responder analysis.
The results indicate that PS-DHA may improve cognitive performance in non-demented elderly with memory complaints.
Post-hoc analysis of subgroups suggests that participants with higher baseline cognitive status were most likely to respond to PS-DHA.
The results of this exploratory study should be followed up by additional studies aimed at confirming the present tentative conclusions.
Source: Dementia and Geriatric Cognitive Disorders, Jun 3, 2010;29(5):467-474. PMID: 20523044, by Vakhapova V, Cohen T, Richter Y, Herzog Y, Korczyn AD. Neurology Department, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel. [E-mail: firstname.lastname@example.org]