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Phosphatidylserine Containing Omega-3 Fatty Acids May Improve Memory Abilities in Non-Demented Elderly with Memory Complaints: A Double-Blind Placebo-Controlled Trial – Source: Dementia and Geriatric Cognitive Disorders, Jun 3, 2010

  [ 73 votes ]   [ 1 Comment ]
By Veronika Vakhopova, Amos D Korczyn, et al. • www.ProHealth.com • June 9, 2010


Background: Phosphatidylserine (PS) may have beneficial effects on cognitive functions. We evaluated the efficacy of a novel preparation of phosphatidylserine containing omega-3 long-chain polyunsaturated fatty acids [docosa/hexaenoic acid (DHA), obtained from fish oil] attached to its backbone (PS-DHA) in non-demented elderly with memory complaints.

Methods: 157 participants were randomized to receive either PS-DHA or placebo for 15 weeks. Efficacy measures, assessed at baseline and endpoint, included:

• The Rey Auditory Verbal Learning Test,

• Rey Complex Figure Test,

• And a computerized cognitive battery.

Clinicians' Global Impression of Change was assessed following 7 and 15 weeks of treatment.

Results: 131 participants completed the study, although 9 were excluded from the efficacy analysis due to protocol violation.

• At endpoint, verbal immediate recall was significantly improved in the PS-DHA group compared to the placebo group.

• Post-hoc analysis revealed that a subset of participants with relatively good cognitive performance at baseline had significant treatment-associated improvements in:
-    Immediate and delayed verbal recall,
-    Learning abilities,
-    And time to copy complex figure.

These favorable results were further supported by responder analysis.

Conclusions:

The results indicate that PS-DHA may improve cognitive performance in non-demented elderly with memory complaints.

Post-hoc analysis of subgroups suggests that participants with higher baseline cognitive status were most likely to respond to PS-DHA.

The results of this exploratory study should be followed up by additional studies aimed at confirming the present tentative conclusions.

Source: Dementia and Geriatric Cognitive Disorders, Jun 3, 2010;29(5):467-474. PMID: 20523044, by Vakhapova V, Cohen T, Richter Y, Herzog Y, Korczyn AD. Neurology Department, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel. [E-mail: amoskor@post.tau.ac.il]





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Article Comments Post a Comment

Phosphatidylserine
Posted by: kwd
Jun 18, 2010
How much of each supplement were they taking to improve their memory? How much is recommended for FM patients who are not geriatric? Does the amount increase for patients with severe FM (and long term FM)verses new patients and patients with moderate to mild symptoms? I have had FM since gradeschool, and always thought (as an adult) that I had ADD, without the hyperactivity. Being forgetful has just been a way of life for me, but it has been getting worse for the last few years, and I cannot retire anytime soon. I need help remembering, just to keep my job, not to mention getting my life back.
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