ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Ultrasound Therapy for Fibromyalgia and Lyme Disease

Curcumin: The All In One Solution, Part 2

What Are the Benefits of Vitamin K2?

Vitamin D deficiency + high fat diet = metabolic syndrome

Why You Should Take Your Apple Cider Vinegar at Night

Use Burdock Oil to Promote Healthy Hair Growth

AMA journal associates iron deficiency with hearing loss

Meet Your Weight Loss Goals

People with forms of early-onset Parkinson's disease may benefit from boosting niacin in diet, resea...

Lutein linked to preservation of crystallized intelligence

 
Print Page
Email Article

Water’s Unexpected Role in Blood Pressure Regulation

  [ 80 votes ]   [ Discuss This Article ]
www.ProHealth.com • July 7, 2010


“The newly discovered system and its molecular mediators… may be targets for blood pressure regulation, particularly in situations of low blood pressure and fainting.”

Name a drink that can make you more alert for late-night studying, prevent you from fainting after giving blood, and even promote a teensy bit of weight loss.

Chances are you didn't say water. But that's the right answer.

Researchers at Vanderbilt University Medical Center’s Autonomic Dysfunction Center have shown that ordinary water - without any additives - does more than just quench thirst. It has some other unexpected, physiological effects.

It increases the activity of the sympathetic – fight or flight – nervous system, which raises alertness, blood pressure and energy expenditure.

David Robertson, MD, and colleagues first observed water's curious ability to increase blood pressure about 10 years ago, in patients who had lost their baroreflexes – the system that keeps blood pressure within a normal range. The observation came as a complete surprise, said Robertson, professor of Medicine, Pharmacology and Neurology.

"We had to unlearn the idea that water had no effect on blood pressure, which is what all medical students had been told until the last couple of years."

Although water does not significantly raise blood pressure in healthy young subjects with intact baroreflexes, the investigators found that it does increase sympathetic nervous system activity and constrict blood vessels (which prevents pooling of blood in the extremities).

These findings prompted the American Red Cross to conduct a study of water drinking as a method for reducing fainting responses. The study found that drinking 16 ounces of water before blood donation reduced the fainting response by 20%.

"This response to water may turn out to be very important for retaining blood donors," Robertson said. "If you pass out after giving blood, you pretty much never give blood again. If we can reduce fainting by 20%, we can reduce the unpleasantness of passing out and really bolster the number of people who can continue to be blood donors."

Julia McHugh, a student in Vanderbilt University School of Medicine's Medical Scientist Training Program, tackled the questions of where water is acting, and how, in a series of studies in mice. The team's latest findings are reported in the June issue of the journal Hypertension.(1)

McHugh and colleagues found that water introduced directly into the stomach or duodenum (the first part of the small intestine) raised blood pressure, which ruled out an oral or esophageal mechanism for the response. They also tested a similar volume of saline (salt-containing solution). This did not raise blood pressure, which suggested that:

• Stretch of the tissues was not part of the mechanism

• And that perhaps water's lack of salt might be important.

The investigators ultimately determined that:

• Water dilutes the plasma in the blood vessels leading away from the duodenum,

• And that this short-lived reduction in salt concentration (hypo-osmolality) is responsible for water's blood pressure-raising (pressor) effect.

• They implicated a protein called Trpv4 in the mechanism: mice lacking the Trpv4 gene did not have a pressor response to water.

• While it is clear that water evokes a pressor response, the normal role for this physiological system is not certain.

Because it raises sympathetic nervous system activity – and consequently energy expenditure – it does promote weight loss, Robertson said.

"I calculated it might be as much as five pounds a year if you drank three 16 ounce glasses of water a day and nothing else changed. This is not going to be the answer to the weight problem in the United States, but it's interesting that activation of the sympathetic system is enough to do that."

McHugh said she found it fascinating that mice and humans share "such a primitive system, and yet we don't know why it's there or what beneficial effects it might have."

The newly discovered system and its molecular mediators – such as Trpv4 – may be targets for blood pressure regulation, particularly in situations of low blood pressure and fainting, the investigators said.

The findings also suggest that investigators who use water as a control substance (a "non-drug") in studies may need to take water's pressor effects into account.

The National Institutes of Health provided funding for the research.
___
Source: Vanderbilt University Medical Center news release, Jul 5, 2010

1. Citation: “Portal Osmopressor Mechanism Linked to Transient Receptor Potential Vanilloid 4 and Blood Pressure Control”  McHugh J, et al. Hypertension, June 2010.

 




Post a Comment

Featured Products From the ProHealth Store
Vitamin D3 Extreme™ Energy NADH™ 12.5mg Mitochondria Ignite™ with NT Factor®

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid

Natural Remedies

Top 3 Nutrients to Detox the Liver and Soothe Digestion Top 3 Nutrients to Detox the Liver and Soothe Digestion
Olea25 Olive Hydroxytyrosol Hits Astonishing 68,000+ ORAC Antioxidant Value Olea25 Olive Hydroxytyrosol Hits Astonishing 68,000+ ORAC Antioxidant Value
Fighting Fatigue with Ground-breaking French Oak Wood Extract Fighting Fatigue with Ground-breaking French Oak Wood Extract
Herbal Inflammation Management for Whole Body Health Herbal Inflammation Management for Whole Body Health
Live Without Anxiety or Stress Live Without Anxiety or Stress

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map