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Mortality in fibromyalgia: An 8,186 patient study over 35 years – Source: Arthritis Care & Research, Jul 26, 2010

  [ 9 votes ]   [ Discuss This Article ]
By F Wolfe, et al. • • July 28, 2010

Purpose: To determine if mortality is increased among patients diagnosed with fibromyalgia.

Methods: We studied 8,186 fibromyalgia patients seen between 1974 and 2009 in 3 settings: all fibromyalgia patients in a clinical practice, patients participating in the US National Data Bank for Rheumatic Diseases (NDB), and patients invited to participate in the NBD who refused participation. Internal controls included 12, 329 patients with osteoarthritis.

Deaths were determined by multiple source communication, and all patients were also screened in the US National Death Index (NDI). We calculated standardized mortality ratios (SMR) based on age and sex stratified US population data, after adjustment for NDI non-response.

Results: There were 539 deaths, and the overall SMR was 0.90 (95% CI 0.61, 1.26). Among 1,665 clinic patients the SMR was 0.92 (95% CI 0.81, 1.05). Sensitivity analyses varying the rate of NDI non-identification did not alter the non-association.

• Adjusted for age and sex, the hazard ratio for fibromyalgia compared with osteoarthritis was 1.05 (95% CI 0.94, 1.17). [Essentially the same.]

• The standardized mortality odds ratio compared with the US general population:
- Was increased for suicide, OR 3.31 (2.15, 5.11), and for accidental deaths, 1.45 (1.02, 2.06),
- But not for malignancy.

Conclusions: Mortality does not appear to be increased in patients diagnosed with fibromyalgia, but the risk of death from suicide and accidents was increased.

Source: Arthritis Care & Research, Jul 26, 2010. PMID: 20662040, by Wolfe F, Hassett AL, Walitt B, Michaud K. National Data Bank for Rheumatic Diseases, Wichita, Kansas.

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