ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Is Coconut Oil Healthy? (The American Heart Association Doesn’t Think So)

American Heart Association Renders Itself Obsolete With 1960s Dietary Advice on Coconut Oil

Ginger Fights Obesity

Health Benefits of Artichokes

Putting the Spotlight on Coriander Seed Oil

Migraines? Powdered Ginger May Help

Are Americans Really Getting Too Much Vitamin D? A Critical Look at Recent Media Warnings

Inflammation Disrupts Memory - What Can You Do to Protect Your Brain?

Eating more vegetable protein may protect against early menopause

Is Activated Charcoal Beneficial?

 
Print Page
Email Article

Acetaminophen even once a month linked to doubled risk of asthma in adolescents, worldwide study finds

  [ 13 votes ]   [ Discuss This Article ]
www.ProHealth.com • August 13, 2010


More indications that young people & OTC pain/fever relievers may not be a good mix.*

New evidence linking the use of acetaminophen [aka Tylenol, Anacin, paracetamol, etc.] to development of asthma, eczema and hay fever suggests that even monthly use of the drug in adolescents may more than double risk of asthma compared to those who used none at all. Even once-a-year use was associated with a 50% increase in the risk of asthma.

The research results were published online Aug 13 by the American Journal of Respiratory and Critical Care Medicine (http://ajrccm.atsjournals.org).

"This study has identified that the reported use of acetaminophen in 13- and 14-year-old adolescent children was associated with an exposure-dependent increased risk of asthma symptoms," said study first author Richard Beasley, MD, director of the Medical Research Institute of New Zealand - on behalf of the International Study of Asthma and Allergies in Childhood (ISAAC).

[To hear an audio clip explanation of the study findings, click here]

Data on More than 300,000 Youngsters in 50 Countries

As part of the ISAAC program, two written questionnaires and one video questionnaire were administered to more than 300,000 13- and 14-year-old children in 113 centers throughout 50 countries, asking them to quantify their use of acetaminophen (none, "medium" - at least once in the last year, or "high" - at least once in the last month) and their asthma, eczema and allergy symptoms.

There was a significant association between acetaminophen use and risk of asthma and eczema.

• For medium users the risk of asthma 43% higher than for non-users;br />
• High users had 2.51 times the asthma risk of non-users.

• For eczema, the relative risks were 31% and 99% greater, respectively.

Similarly, the risk of rhinoconjunctivitis (allergic nasal congestion or “hay fever”) was:

• 38% higher for medium users,

• And 2.39 times as great for high users compared to non-users.

But Is It a Matter of Cause & Effect?

As this was a cross-sectional study, causality could not be determined. However, there is mounting evidence that suggests a causal link.

• A longitudinal study [over time] on a small population in Ethiopia that examined the risk of asthma and allergies associated with acetaminophen use elucidated a temporal relationship between acetaminophen usage and the development of asthma and allergy symptoms, lending greater evidence to the possibility that acetaminophen usage may indeed cause the increased risk. This study (“The Role Of Paracetamol, Geohelminths And Other Environmental Exposures On The Incidence Of Wheeze And Eczema In An Ethiopian Birth Cohort,” by Amberbir A, et al.) will also be published online in the American Journal of Respiratory and Critical Care Medicine.

• Moreover, in an earlier study from the United States, 13- and 14-year-old children with asthma were randomized to take either acetaminophen or ibuprofen after a febrile illness. For those whose illness was respiratory, there was an increased risk of a subsequent outpatient visit for asthma.

And if So, What Might Be the Reason?

There are a number of biologically plausible explanations for how acetaminophen might increase risk of asthma and allergy.

• Acetaminophen may have a systemic inflammatory effect, possibly increasing oxygen stress resulting from the depletion of glutathione-dependent enzymes, which may in turn lead to enhanced TH2 allergic immune responses.

• Furthermore, acetaminophen may suppress the immune response to, and prolong the symptomatic illness from, rhinovirus infections, which are a common cause of severe asthma exacerbations in childhood.

Given the increased risk associated with acetaminophen usage, Dr. Beasley and colleagues calculated that the population attributable risks - the percentage of cases that might be avoided if the risk factor were to be eliminated - were indicative of a remarkable impact from acetaminophen usage.

"The overall population attributable risks for current symptoms of severe asthma were around 40%, suggesting that if the associations were causal, they would be of major public health significance," said Dr. Beasley. "Randomized controlled trials are now urgently required to investigate this relationship further and to guide the use of antipyretics, not only in children but in pregnancy and adult life."
____
* Parents are advised not to give children aspirin (or other salicylate-containing medications), to avoid risk of Reye’s syndrome. And, because studies have indicated that ibuprofen (aka Advil, Motrin, etc.) may initiate or exacerbate asthma symptoms, acetaminophen had been considered the pain reliever of choice for those with asthma.

Source: American Thoracic Society news release, Aug 13, 2010




Post a Comment

Featured Products From the ProHealth Store
Ultra ATP+, Double Strength FibroSleep™ Vitamin D3 Extreme™

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength

Natural Remedies

Block food Cravings At Their Molecular Root Block food Cravings At Their Molecular Root
Soothe, Heal and Regulate Your Digestive System with Nutrient-Rich Aloe Vera Soothe, Heal and Regulate Your Digestive System with Nutrient-Rich Aloe Vera
Can Glycine + Amino Acids Be the Secret to Deep, Rejuvenating Sleep? Can Glycine + Amino Acids Be the Secret to Deep, Rejuvenating Sleep?
Repair Damaged Mitochondria and Reduce Fatigue Up to 45% Repair Damaged Mitochondria and Reduce Fatigue Up to 45%
The Crucial Role CoQ10 Plays in Fibromyalgia and ME/CFS The Crucial Role CoQ10 Plays in Fibromyalgia and ME/CFS

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map