ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Curcumin: The All In One Solution, Part 2

CoQ10 — A Nutritional Powerhouse for Mitochondrial Health

What Are the Benefits of Vitamin K2?

Vitamin D deficiency + high fat diet = metabolic syndrome

Use Burdock Oil to Promote Healthy Hair Growth

Why You Should Take Your Apple Cider Vinegar at Night

AMA journal associates iron deficiency with hearing loss

Lutein linked to preservation of crystallized intelligence

Zinc eaten at levels found in biofortified crops reduces 'wear and tear' on DNA

A handful of nuts a day cuts the risk of a wide range of diseases

 
Print Page
Email Article

Characterization of antibodies elicited by XMRV infection and development of immunoassays useful for epidemiologic studies – Source: Retrovirology, Aug 17, 2010

  [ 8 votes ]   [ Discuss This Article ]
By Xiaoxing Qiu, et al. • www.ProHealth.com • August 17, 2010


[Note: to read the full text of this article free, click HERE.]

Background: Xenotropic Murine Leukemia Virus-related Virus (XMRV) is a human gammaretrovirus recently identified in prostate cancer tissue and in lymphocytes of patients with chronic fatigue syndrome.

To establish the etiologic role of XMRV infection in human disease requires large scale epidemiologic studies. Development of assays to detect XMRV-specific antibodies would greatly facilitate such studies.

However, the nature and kinetics of the antibody response to XMRV infection have yet to be determined.

Results: Three rhesus macaques were infected with XMRV to determine the dynamics of the antibody responses elicited by infection with XMRV.

All macaques developed antibodies to XMRV during the second week of infection, and the predominant responses were to the envelope protein gp70, transmembrane protein p15E and capsid protein p30.

In general, antibody responses to gp70 and p15E appeared early with higher titers than to p30, especially in the early period of seroconversion.

Antibodies to gp70, p15E and p30 persisted to 158 days and were substantially boosted by re-infection, thus, were identified as useful serologic markers.

Three high-throughput prototype assays were developed using recombinant proteins to detect antibodies to these viral proteins. Both gp70 and p15E prototype assays demonstrated 100% sensitivity by detecting all Western Blot (WB) positive serial bleeds from the XMRV-infected macaques and good specificity (99.5-99.9%) with blood donors.

Seroconversion sensitivity and specificity of the p30 prototype assay was 92% and 99.4% respectively.

Conclusions: This study provides the first demonstration of seroconversion patterns elicited by XMRV infection.

• The nature and kinetics of antibody responses to XMRV in primates were fully characterized.

• Moreover, key serologic markers useful for detection of XMRV infection were identified.

• Three prototype immunoassays were developed to detect XMRV-specific antibodies.

• These assays demonstrated good sensitivity and specificity; thus will facilitate large scale epidemiologic studies of XMRV infection in humans.

Source: Retrovirology, Aug 17, 2010. doi:10.1186/1742-4690-7-68 by Qiu X, Swanson P, Luk K, Tu B, Villinger F, Das Gupta J, Silverman RH, Klein EA, Devare s, Schochetman g, Hackett J Jr. Abbott Diagnostics, Abbott Park, Illinois; Department of Pathology, Emory University School of Medicine/Yerkes National Primate Research Center, Atlanta, Georgia; Department of Cancer Biology, Lerner Research Institute, and Glick Urological and Kidney Institute and LRI, Cleveland Clinic Foundation, Cleveland, Ohio, USA. [See also “Characterization of XMRV in prostate cancer,” March 2010.]




Post a Comment

Featured Products From the ProHealth Store
Mitochondria Ignite™ with NT Factor® Optimized Curcumin Longvida® Vitamin D3 Extreme™

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function

Natural Remedies

Itching to Find Dry Skin Relief? Itching to Find Dry Skin Relief?
Block Acid Reflux to Prevent Esophageal Problems! Block Acid Reflux to Prevent Esophageal Problems!
A Hard-Working Molecule that May Help Ease Pain & Brighten Mood A Hard-Working Molecule that May Help Ease Pain & Brighten Mood
Herbal Inflammation Management for Whole Body Health Herbal Inflammation Management for Whole Body Health
Vitamin K-2 – A Key Player in Cardiovascular and Bone Health Vitamin K-2 – A Key Player in Cardiovascular and Bone Health

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map