ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

B Vitamins May Protect Against Damaging Effects of Air Pollution, and Improve Cognition and Psychiat...

Relief for IBS, Colitis, Crohn’s And More

Can Magnesium Relieve Your Tinnitus?

Restless Leg Syndrome (RLS) - are you running a marathon each night?

Resveratrol Proven to Slow Brain Aging

Magnesium Protects Against Stroke, Heart Disease and Diabetes

Fruits and vegetables' latest superpower? Lowering blood pressure

Neroli Oil: The Pleasantly Fragrant Citrus Oil

Restoring NAD+ could reduce DNA damage accumulation

Whole-body vibration may be as effective as regular exercise

 
Print Page
Email Article

Oxidative Damage and Progression to Alzheimer's Disease in Patients with Mild Cognitive Impairment – Source: Journal of Alzheimers Disease, Aug 6, 2010

  [ 8 votes ]   [ Discuss This Article ]
By I Baldeiras, et al. • www.ProHealth.com • August 18, 2010


Recent studies show that most of the oxidative changes [free radical damage to all cellular components] found in Alzheimer's disease (AD) are already present in mild cognitive impairment (MCI) patients.

The question arises as to whether oxidative stress has a role in the progression of MCI to AD.

We conducted a longitudinal study [tracked over time] on 70 MCI patients, and the peripheral blood levels of a broad spectrum of non-enzymatic and enzymatic antioxidant defenses, as well as lipid and protein oxidation markers, and nitrogen oxidative species were determined.

At baseline, there were no differences in any of the indexes of oxidative damage between stable MCI patients (MCI-MCI) and patients that progressed to AD (MCI-AD).

Cellular levels of lipid peroxidation markers increased in both groups and this was accompained in MCI-AD, but not in MCI-MCI patients, by a significant decrease in cellular antioxidant defenses (oxidyzed/reduced glutathione ratio and vitamin E). [Note: Vitamin E is actually a family of fat-soluble vitamins called tocopherols/tocotrienols that are active throughout the body and work with other nutrients including vitamin C, glutathione, selenium and vitamin B-3 to keep oxygen molecules from becoming too reactive/destructive.]

Among MCI-AD patients, the longitudinal decrease in cellular vitamin E was associated with the deterioration in cognitive performance.

These results suggest:

• That accumulation of oxidative damage may start in pre-symptomatic phases of AD pathology.

• And that progression to AD might be related to depletion of antioxidant defenses.

Source: Journal of Alzheimers Disease, Aug 6, 2010. PMID: 20693652, by Baldeiras I, Santana I, Proença MT, Garrucho MH, Pascoal R, Rodrigues A, Duro D, Oliveira CR. Laboratory of Neurochemistry, Neurology Department, Coimbra University Hospital; Portugal Center for Neuroscience and Cell Biology Faculty of Medicine, University of Coimbra, Portugal.




Post a Comment

Featured Products From the ProHealth Store
Optimized Curcumin Longvida® Selenium Vitamin E with Mixed Tocopherols

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Selenium Selenium
Activates antioxidant glutathione for cell protection
Vitamin E with Mixed Tocopherols Vitamin E with Mixed Tocopherols
The core antioxidant for everyday health
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils

Natural Remedies

Herbal Rescue for High Blood Sugar Herbal Rescue for High Blood Sugar
Anti-Inflammatory Properties of Tart Cherry Anti-Inflammatory Properties of Tart Cherry
Everything You Always Wanted to Know About Sleep But Were Too Tired to Ask Everything You Always Wanted to Know About Sleep But Were Too Tired to Ask
Block Acid Reflux to Prevent Esophageal Problems! Block Acid Reflux to Prevent Esophageal Problems!
Strengthen Cell Function with Energy-Boosting Niagen Strengthen Cell Function with Energy-Boosting Niagen

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map