ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Fighting Heartburn and Gerd Naturally – And Safely!

Natural Bladder Control, Go Less and Live More

Vital Molecule Increases Cellular Energy and Improves Cognitive Function

Top Vitamin and Mineral Deficiencies — Are You at Risk?

Trimming the spare tire: Canola oil may cut belly fat

How Pomegranate May Protect Against Cancer

Omega Fix for Obesity: How the Right Fats Fight Fat

The Onion: Cancer Fighter and Food Preserver

Probiotics improve cognition in Alzheimer's patients

Curcumin Reverses the Cellular Damage of Chronic Stress

 
Print Page
Email Article

RA ‘signaling protein’ reverses Alzheimer’s plaque & memory loss in animals: Major breakthrough seen

  [ 20 votes ]   [ Discuss This Article ]
www.ProHealth.com • August 25, 2010


“We were pretty amazed that the treatment completely reversed cognitive impairment in 20 days,” the researchers state, and luckily a human form of the protein is already FDA approved with a good safety record for immune support of certain cancer patients.

A signaling protein released during rheumatoid arthritis dramatically reduced Alzheimer’s disease pathology and reversed the memory impairment of mice bred to develop symptoms of the neurodegenerative disease, a new study by the University of South Florida reports. Researchers found that the protein, GM-CSF, likely stimulates the body’s natural scavenger cells to attack and remove Alzheimer’s amyloid deposits in the brain.

The study was published online Aug 23 in the Journal of Alzheimer’s Disease. (See “GM-CSF upregulated in Rheumatoid Arthritis reverses cognitive impairment and amyloidosis in Alzheimer mice.”)

People with rheumatoid arthritis, a chronic disease leading to inflammation of joints and surrounding tissue, are less likely than those without arthritis to develop Alzheimer’s.

•  While it was commonly assumed that non-steroidal anti-inflammatory drugs (NSAIDs) may help prevent onset and progression of Alzheimer’s disease,

•  Recent NSAID clinical trials proved unsuccessful for patients with Alzheimer’s.

The USF researchers are among the first to look at what role innate immunity gone awry in rheumatoid arthritis may play in protecting against Alzheimer’s disease.

“Our findings provide a compelling explanation for why rheumatoid arthritis is a negative risk factor for Alzheimer’s disease,” said principal investigator Huntington Potter, PhD, http://health.usf.edu/medicine/faculty_council/President+-+Huntington+Potter+PhD.htm a professor of molecular medicine at USF’s Health Byrd Alzheimer’s Institute and director of the Florida Alzheimer’s Disease Research Center.

“Moreover, the recombinant human form of GM-CSF (Leukine®) is already approved by the FDA and has been used for years to treat certain cancer patients who need to generate more immune cells,” Dr. Potter said.

“Our study, along with the drug’s track record for safety, suggests Leukine should be tested in humans as a potential treatment for Alzheimer’s disease.”

The researchers analyzed three rheumatoid arthritis growth factors in mouse models and identified the signaling protein GM-CSF as the most promising for potential protective benefit against Alzheimer’s disease. Then, they peripherally injected GM-CSF into two groups of mice – those genetically altered to develop memory problems mimicking Alzheimer’s disease and normal, aged mice. Behavioral tests confirmed the Alzheimer’s mice were exhibiting signs of memory impairment at age 12 months. Another two control groups of mice - Alzheimer’s mice and normal mice - were administered saline (placebo).

After the 10th day of injections, all the mice began a series of behavioral testing. At the end of the 20-day study:

•  The cognitively impaired mice treated with GM-CSF performed substantially better on tests measuring their working memory and learning.

•  In fact, their memories were similar to normal aged mice without dementia.

•  Even the normal mice treated with GM-CSF performed slightly better than their untreated peers.

•  The Alzheimer’s mice administered saline continued to do poorly on the tests.

“We were pretty amazed that the treatment completely reversed cognitive impairment in 20 days,” said Tim Boyd, PhD, who, together with Steven Bennett, PhD, is a study lead author.

•  In addition, the brains of GM-CSF-treated Alzheimer’s mice showed more than a 50-percent decrease in beta amyloid, a substance forming the sticky clumps of plaques that are a hallmark of Alzheimer’s disease.

•  This reduction in Alzheimer’s plaques and associated restoration of memory was accompanied by more immune cells known as microglia in the brain. Microglia are like the body’s natural garbage collection cells that rush to damaged or inflamed areas to get rid of toxic substances.

The researchers suggest that GM-CSF - boosted during the immune system overdrive of rheumatoid arthritis - helps harness the beneficial properties of inflammation in the brain.

The protein may do this by recruiting more microglia from the peripheral blood into the brain to remove Alzheimer’s plaques, Dr. Potter said.

An apparent increase in neural cell connections in the brains of the GM-CSF-treated mice may also help explain GM-CSF’s association with improving memory decline in Alzheimer’s disease, the researchers said.

The USF Health Byrd Alzheimer’s Institute  plans to begin a pilot clinical trial this year investigating GM-CSF (Leukine) in patients with mild or moderate Alzheimer’s disease.
___
Source: University of South Florida news release, Aug 23, 2010




Post a Comment

Featured Products From the ProHealth Store
Mitochondria Ignite™ with NT Factor® Optimized Curcumin Longvida® Ultra EPA  - Fish Oil


Article Comments



Be the first to comment on this article!

Post a Comment


 
Natural Pain Relief Supplements

Featured Products

FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function

Natural Remedies

Fight Inflammation and Promote Cognitive Health with High-OPC Grape Seed Fight Inflammation and Promote Cognitive Health with High-OPC Grape Seed
Natural Support for Mood, Sleep and Mental Focus? L-theanine Natural Support for Mood, Sleep and Mental Focus? L-theanine
When a Negative is Positive - Goodnighties Recovery Sleepwear When a Negative is Positive - Goodnighties Recovery Sleepwear
Relief for Dry, Itchy Skin Caused by Fibromyalgia Relief for Dry, Itchy Skin Caused by Fibromyalgia
Energy Breakthrough - One Fibromyalgia Patient’s Fortuitous Discovery Energy Breakthrough - One Fibromyalgia Patient’s Fortuitous Discovery

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map