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80% of depressed subjects achieved remission with noninvasive electrical stimulation of facial nerve - UCLA

  [ 18 votes ]   [ Discuss This Article ] • September 3, 2010

Little ‘TNS’ device stimulates trigeminal nerve during sleep via stick-on disks on forehead.

Major depression is a common and disabling brain condition marked not only by the presence of depressed mood but also by its effects on sleep, energy, decision-making, memory and thoughts of death or of suicide.
Major depression affects 15 million adults in the U.S., and the World Health Organization projects that by 2020 it will be the largest contributor to disability in the world after heart disease.
While antidepressants have helped many to recover and resume their lives:

• Only 30% of patients will experience full remission with the first medication they use. Patients typically move on to try a series of other antidepressants.

• A persistent problem with such drugs has been major side effects, including obesity, sexual dysfunction, fatigue, drowsiness and nausea.
Now, a unique new therapy that applies electrical stimulation to a major nerve emanating from the brain is showing promise.
In a recently completed clinical trial at UCLA, trigeminal nerve stimulation (TNS) achieved an average of a 70%  reduction in symptom severity over an eight-week study period. [See diagram showing the three branches of trigeminal nerve on the face.]

The study's principal investigator, neuroscientist Ian A. Cook, MD, presented the results at a recent National Institutes of Health conference on depression and other psychiatric disorders.

Dr. Cook, a professor of psychiatry at UCLA’s Semel Institute for Neuroscience and Human Behavior, reported that 80% of the subjects achieved remission, a highly significant result in this pilot study.
TNS is Not New to UCLA.

It was pioneered for treatment-resistant epilepsy in humans by Dr. Christopher M. DeGiorgio, a UCLA professor of neurology. The results of a positive 12-patient feasibility trial in epilepsy were reported last year in the journal Neurology. A larger, double-blind pilot epilepsy clinical trial is underway at UCLA and the University of Southern California.

The Device

The stimulator that was used in the depression clinical trial is about the size of a large cell phone. Two wires from the stimulator are passed under the clothing and connected to electrodes attached to the forehead by adhesive. The electrodes transmit an electrical current to the nerve.

All the patients in the trial used the device for approximately eight hours every night while asleep. In contrast to antidepressants, no major side effects were noted.
"The major branches of the trigeminal nerve in the face are located close to the surface of the skull and can be stimulated either with non-invasive external electrodes, as we used in this trial, or with minimally invasive subcutaneous electrodes," Cook said.
He added that some patients may prefer to have miniature subcutaneous electrodes implanted under the skin rather than applying new electrodes daily.
A Signaling Pathway

In describing TNS, DeGiorgio, co-principal investigator for the depression trial, explained that what is remarkable about the TNS approach is that it is possible to send signals to key structures deep in the brain without penetrating into the skull.
Cook hypothesized that electrical stimulation of the trigeminal nerve generates a cascading sequence of events in the existing neuronal infrastructure. In essence, he said, "TNS provides a high-bandwidth pathway into the brain."
Accelerated Development for Public Benefit

To help bring the TNS out of the laboratory and into patient care, UCLA's Office of Intellectual Property recently executed an exclusive worldwide license for the TNS with NeuroSigma, a Los Angeles-based neuromodulation company formed in 2008 to commercialize promising technologies developed at leading universities and research institutions.

Drs. DeGiorgio and Cook are among UCLA's inventors of the TNS technology and are unpaid advisers to NeuroSigma. Dr. Antonio De Salles and Jack Judy, also UCLA faculty members, are co-founders of NeuroSigma and are minority shareholders. They report no role in this project.
The project was supported by the Joanne and George Miller and Family Endowment in Depression Research and by an anonymous philanthropic donation to UCLA.

TNS & Other Depression Trials Recruiting at UCLA

For more information about depression research projects currently open for enrollment at UCLA, including various antidepressant medications, TMS, and electrical trigeminal nerve stimulation, go to


Source: University of California Los Angeles news release, Sep 2, 2010

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