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Thyroid autoimmunity may represent a predisposition for the development of fibromyalgia? – Source: Rheumatology International, Nov 18, 2010

  [ 15 votes ]   [ 5 Comments ]
By Laura Bazzichi, et al. • • November 19, 2010

In our previous study, we observed that the presence of autoimmune thyroid disease worsens fibromyalgia (FM) symptoms. ["Association between thyroid autoimmunity and fibromyalgia disease severity," Clinical Rheumatology, 2007.]

The aims of this study are to evaluate whether there is a predisposition for the development of FM in patients with Hashimoto's thyroiditis (HT) with or without subclinical hypothyroidism (SCH) and in patients with SCH alone, and what is the weight of antithyroid antibody positivity and SCH on FM comorbidity.

Fifty-two patients, 39 affected by HT with or without SCH and 13 by SCH, were matched with 37 patients affected by FM and 25 healthy subjects.

Blood samples were collected from all study subjects for the determination of serum TSH, free triiodothyronine, free thyroxine, antithyroperoxidase antibody (TPOAb), antithyroglobulin antibody (TgAb) and non-organ-specific autoantibodies.

Clinical assessment of patients and controls included the "Fibromyalgia Impact Questionnaire" (FIQ), while pain severity was evaluated using a visual analogue scale (VAS). Patients and controls were also characterized by the presence of diffuse pain, fatigue, paresthesiae, muscle spasms, non-restful sleep, tension headache and presence of mood disorders.

• FM comorbidity resulted in 12 HT subjects (31%) and none in SCH patient.

• In particular, FM comorbidity in HT patients without SCH was 33.3% and in HT patients with SCH was 28.5%.

Based on our data, we speculate that maybe there is more than a hypothesis regarding the cause-effect relation between thyroid autoimmunity and the presence of FM, thus suggesting a hypothetical role of thyroid autoimmunity in FM pathogenesis.

Source: Rheumatology International, Nov 18, 2010. PMID: 21085966, by Bazzichi L, Rossi A, Zirafa C, Monzani F, Tognini S, Dardano A, Santini F, Tonacchera M, De Servi M, Giacomelli C, De Feo F, Doveri M, Massimetti G, Bombardieri S. Division of Rheumatology, Department of Internal Medicine, University of Pisa, Pisa, Italy., [Email:]

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Article Comments Post a Comment

Posted by: Celia2000
Dec 1, 2010
I have both of these, however I developed FM 15 years before I was diagnosed with Hashimoto's. What does this mean in terms of this article?
Reply Reply

fibro and thyroid
Posted by: Sandy10m
Dec 2, 2010
I also have fibro, but my thyroid was sub-clinically low, meaning that I had all the symptoms of low thyroid, but my blood tests came back normal. A very smart nutritionist put me on a natural form of thyroid supplementation (Spectra) on a slow increase schedule. I immediately started to feel better, and today my fibro is mostly under control. So, since I don't have Hashimoto's, or any diagnosed thyroid problem, it is entirely possible that a low thyroid condition (with or without low blood tests) is definitely connected to fibro. Your thyroid could have been in distress 15 years ago, but the Hashimoto's might only have occurred more recently. This is one possibility anyway.
Reply Reply

thyroid autoimmunity and predispositon for FM..
Posted by: Emari411
Dec 4, 2010
Sandy10M I can't thank you enough for giving me some hope. Is it possible to contact you in any way to find out your location and/or the name of your nutritionist. I've been floundering for a very long time and this sounds promising to me. Thanks..Emari


Duh. Some doctors have known this for years.
Posted by: evilgalblues
Dec 6, 2010
Dr. John Lowe wrote 'The Metabolic Treatment of Fibromyalgia' on this subject and has been preaching it for years. Once I got proper treatment for my undiagnosed severe Hashimoto's, my FM symptoms got under control and I just have my other co-diseases to deal with most of the time. I can tell as soon as my thyroid gets out of balance tho- the FM comes back with a vengeance.
Reply Reply

Would like recommendations!
Posted by: rwrightsox
Dec 30, 2010
Hello fellow sufferers, and it sounds like some are not suffering anymore so good for you! I'm on to my 10th specialist next week. Have done much research over the last 7 years of being very ill! I truly believe most of my illness is from undertreated thyroid disease, Hashimotos to be precise and lead to Fibromyalgia/CFS being labeled upon me! After suffering on Levo. for 6 years finally got off that and got onto NDT, Erfa from Canada, similar to Armour. Now I think I am one of those rare pt.'s that doesn't even respond to that, the meds are just circulating in my blood, not getting to the cells and tissues to make me well! I know after research low Ferritin, low Vit. D, low Vit B12, doesn't help this so I'm taking lots of supplements and not getting well,even getting worse!I hear some pt.'s respond to T3 only treatment. Is there anyone out there that has responded to this or other treatments when NOTHING else worked?? If you could please email me your treatment plans, etc...I have alot of ideas for this new specialist but would appreciate any help I can get. Thank you in advance, I wish a healthy peaceful 2011 for everyone, Renee


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