ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Fighting Heartburn and Gerd Naturally – And Safely!

Vital Molecule Increases Cellular Energy and Improves Cognitive Function

Natural Bladder Control, Go Less and Live More

Top Vitamin and Mineral Deficiencies — Are You at Risk?

Trimming the spare tire: Canola oil may cut belly fat

How Pomegranate May Protect Against Cancer

Omega Fix for Obesity: How the Right Fats Fight Fat

Curcumin Reverses the Cellular Damage of Chronic Stress

The Onion: Cancer Fighter and Food Preserver

Probiotics improve cognition in Alzheimer's patients

 
Print Page
Email Article

Northwestern discovers molecular cause of PTSD - and drug that could head it off

  [ 13 votes ]   [ Discuss This Article ]
www.ProHealth.com • December 9, 2010


“We were able to stop the development of exaggerated fear with a simple, single drug treatment and found the window of time we have to intervene” in animals. “This means we could have a prevention approach for humans."

Post-traumatic stress syndrome – when a severely stressful event triggers exaggerated and chronic fear – affects nearly 8 million people in the United States and is hard to treat.

In a preclinical study, Northwestern Medicine scientists have for the first time identified the molecular cause of the debilitating condition and prevented it from occurring by injecting calming drugs into the brain within five hours of a traumatic event.  

Northwestern researchers discovered the brain becomes overly stimulated after a traumatic event causes an ongoing, frenzied interaction between two brain proteins - long after they should have disengaged.

“It’s like they keep dancing even after the music stops,” explained principal investigator Dr. Jelena Radulovic, MD, PhD, associate professor of psychiatry and behavioral sciences at Northwestern University Feinberg School of Medicine and director of the Dunbar Laboratory for Research on Memory and Fear.

When newly developed research drugs MPEP and MTEP were injected into the hippocampus, the calming drugs ended “the dance.”

“We were able to stop the development of exaggerated fear with a simple, single drug treatment and found the window of time we have to intervene,” Dr. Radulovic said. “Five hours is a huge window to prevent this serious disorder.” Past studies have tried to treat the extreme fear responses, after they have already developed, she noted.

The study, conducted with mice, was published Dec. 1 in the journal Biological Psychiatry. ["Metabolic glutamate receptor 5/Homer interactions underlie stress effects on fear."]

An exaggerated fear disorder can be triggered by combat, an earthquake, a tsunami, rape or any traumatic psychological or physical event. 

“People with this syndrome feel danger in everything that surrounds them,” Dr. Radulovic said.

“They are permanently alert and aroused because they expect something bad to happen,” she adds. “They have insomnia; their social and family bonds are severed or strained. They avoid many situations because they are afraid something bad will happen. Even the smallest cues that resemble the traumatic event will trigger a full-blown panic attack.”

In a panic attack, a person’s heart rate shoots up, they may gasp for breath, sweat profusely and have a feeling of impending death.

Many people bounce back to normal functioning after stressful or dangerous situations have passed. Others may develop an acute stress disorder that goes away after a short period of time. But some go on to develop post-traumatic stress syndrome, which can appear after a time lag.

The stage is set for post-traumatic stress disorder after a stressful event causes a natural flood of glutamate, a neurotransmitter that excites the neurons.

The excess glutamate dissipates after 30 minutes, but the neurons remain frenzied. The reason is the glutamate interacts with a second protein (Homer1a), which continues to stimulate the glutamate receptor, even when glutamate is gone.

For the study, Northwestern scientists first subjected mice to a one-hour immobilization, which is distressing to them but not painful. Next, the mice explored the inside of a box and, after they perceived it as safe, received a brief electric shock. Usually after a brief shock in the box, the animals develop normal fear conditioning. If they are returned to the box, they will freeze in fear about 50% of the time. However, after the second stressful experience, these mice froze 80% to 90% of the time.

The animals’ exaggerated chronic fear response continued for at least one month and resembles post-traumatic stress disorder in humans, Dr. Radulovic said.

For the second part of the study, Dr. Radulovic and postdoc fellow Natalie Tronson, PhD, repeated the two stressful experiences with the mice but then injected them with MPEP and MTEP five hours after the immobilization.

This time the mice did not develop the exaggerated fear response and froze for only 50% of the time. “The mice’s fear responses were completely normal,” Radulovic said. “Their memories of the stressful event didn’t trigger the extreme responses anymore.”

“This means we could have a prevention approach for humans exposed to acute, severe stressful events.”

The research was supported by the National Institute of Mental Health.
___
Source: Northwestern University press release, by Marla Paul, Dec 6, 2010




Post a Comment

Featured Products From the ProHealth Store
Ultra EPA  - Fish Oil Mitochondria Ignite™ with NT Factor® Energy NADH™ 12.5mg


Article Comments



Be the first to comment on this article!

Post a Comment


 
Natural Pain Relief Supplements

Featured Products

Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils

Natural Remedies

Stop Bacteria With Nature's Antibiotics Stop Bacteria With Nature's Antibiotics
Mitochondria-Booster NIAGEN® Shows Promise in First Human Clinical Trial Mitochondria-Booster NIAGEN® Shows Promise in First Human Clinical Trial
Safely Burn Away Body Fat Safely Burn Away Body Fat
Live Without Anxiety or Stress Live Without Anxiety or Stress
Improve Cardiovascular and Metabolic Health with Omega-7 Improve Cardiovascular and Metabolic Health with Omega-7

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map