ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Meta-analysis links vitamin D deficiency with increased risk of mortality during 10.5 year median pe...

Prevent Or Reverse Diabetes: An Amazing Herbal Intervention

Exercise and Vitamin D Better Together for Heart Health

VIDEO: Essential Oils for Weight Loss

Can Valerian Root Help You Sleep Better?

Can Ginkgo Give Your Brain a Boost?

Fighting Statin-Induced Diabetes with CoQ10

Eight servings of veggies a day is clearly best for the heart

The Many Wonders of Calming Sandalwood Oil

Curcumin — A Novel Treatment Alternative for Depression

 
Print Page
Email Article

Virologists discover how cells fight Epstein-Barr virus & how EBV works to get the upper hand; eye future therapies

  [ 13 votes ]   [ Discuss This Article ]
www.ProHealth.com • December 22, 2010


About 90% of people are infected at some time in their lives with Epstein-Barr virus (EBV), usually with no ill effects. But individuals with compromised immune systems (such as people with HIV retrovirus infection or organ transplants) have a greater risk of cancer occurring because of this herpesvirus.

Scientists at the Duke Cancer Institute have discovered a pathway that infected cells use to root out EBV infections, a finding that has implications for understanding the human response to cancer-causing viruses in general and, they hope, may yield anti-EBV therapies.

"Using cell culture studies, we have uncovered a major pathway that the infected host cell activates to prevent an oncogenic virus from causing cancer," says Duke virologist Dr. Micah Luftig, PhD, senior author of the study published Dec 15 by Cell Host and Microbe.(1) "We proposed that the cell was sensing that the virus is trying to take over. When this oncogenic stress response is activated, it keeps the virus in check, and now we know why."

The Luftig group also learned how the Epstein-Barr virus overcomes the cell's response.

"The findings may eventually yield therapies to benefit people who don't have good immune systems and who need protection from a threatening EBV infection," Luftig said. Very early in many people's lives, there is a huge expansion of immune system B cells infected with EBV. But thanks to the oncogenic stress response and a strong immune system, the majority of these infected cells are killed off and the person remains healthy.

Dr. Luftig and his group, including lead authors Pavel Nikitin and Chris Yan, found two enzymes, called kinases, which were critical in mediating this oncogenic stress response and preventing unchecked B-cell cell growth, called immortalization.

When the scientists blocked the ATM and Chk2 kinases, unchecked growth resulted in 10 times more infected cells. This burgeoning cell growth is related to several types of cancer, including post-transplant lymphoproliferative disorder, in which a transplant patient gets a form of lymphoma because of B-cell proliferation, and HIV-associated B-cell lymphomas among others.

"This finding can be extended to the general case of any oncogene being activated that might start the process of tumor formation," Luftig said. "About 20% of all human cancers are caused by infectious agents, and about 80% of these infections are viral." Another example of a viral infection leading to cancer is the human papillomavirus, implicated in cervical cancer.

Epstein-Barr virus infection can mean different courses for different people.

• In children 4-5 years old, a first infection with the virus may cause a mild illness,

• But if this primary infection happens during adolescence, the person may suffer a case of mononucleosis with heavy fatigue and other symptoms.

• In immune-compromised people, the virus can do much worse damage and cause forms of lymphoma.

____

Funding for this study came from the American Cancer Society, the National Cancer Institute, the Duke Center for AIDS Research, the Duke Comprehensive Cancer Center, and Golfers Against Cancer.

1. Reference article titled: “An ATM/Chk2-Mediated DNA Damage-Responsive Signaling Pathway Suppresses Epstein-Barr Virus Transformation of Primary Human B Cells” by Nikitin PA, Luftig MA, et al. Cell Host & Microbe, Dec 16, 2010

Source: Duke Cancer Institute news release, Dec 16, 2010




Post a Comment

Featured Products From the ProHealth Store
Optimized Curcumin Longvida® Ultra EPA  - Fish Oil Ultra ATP+, Double Strength

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function

Natural Remedies

When a Good Night's Sleep Is Just a Daydream... When a Good Night's Sleep Is Just a Daydream...
Sleep Like a Baby in Nature's Cradle Sleep Like a Baby in Nature's Cradle
Red Yeast Rice - Natural Option for Supporting Healthy Cholesterol Red Yeast Rice - Natural Option for Supporting Healthy Cholesterol
The Big Blue Fish that Helps Chase the Blues Away The Big Blue Fish that Helps Chase the Blues Away
When a Negative is Positive - Goodnighties Recovery Sleepwear When a Negative is Positive - Goodnighties Recovery Sleepwear

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map