ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Meta-analysis adds evidence to association between omega-3 supplementation and lower heart rate

Friendly User's Guide for the Timing of Nutritional Supplements

The Health Benefits of Manuka Honey

Increase Your Magnesium Intake

Love Your Lungs With Tomatoes and Apples

How to Get Rid of Stretch Marks Naturally

Top Tips to Boost Your Immunity

Essential Oils Lower Blood Pressure

Vitamin D supplementation could ease IBS symptoms

11 Amazing Health Benefits of Using Baking Soda

Print Page
Email Article

Plasma neuropeptide Y: A biomarker for symptom severity in chronic fatigue syndrome - Source: Behavioral and Brain Functions, Dec 29, 2010

  [ 12 votes ]   [ 2 Comments ]
By Mary Fletcher, Nancy Klimas, et al. • • December 30, 2010

[Note: to read the full text of this free access article, click HERE. The 'stress mediating' neurotransmitter neuropeptide Y is a major factor in the brain and body. For example, it affects food intake, anxiety, learning and memory, the cardiovascular system (e.g., contraction of vascular smooth muscle) and the neuroendocrine system/hormone secretion.]

Chronic fatigue syndrome (CFS) is a complex, multi-symptom illness with a multisystem pathogenesis involving alterations in the nervous, endocrine and immune systems.

Abnormalities in stress responses have been identified as potential triggers or mediators of CFS symptoms.

This study focused on the stress mediator neuropeptide Y (NPY). We hypothesized that NPY would be a useful biomarker for CFS.


The CFS patients (n=93) were from the Chronic Fatigue and Related Disorders Clinic at the University of Miami and met the 1994 case definition of Fukuda and colleagues.

Healthy sedentary controls (n=100)) were from NIH or VA funded studies.

Another fatiguing, multi-symptom illness, Gulf War Illness (GWI), was also compared to CFS.

We measured mediator neuropeptide Y (NPY) in plasma using a radioimmunoassay (RIA).

Psychometric measures, available for a subset of CFS patients, included: Perceived Stress Scale, Profile of Mood States, ATQ Positive &Negative Self-Talk Scores, the COPE, the Beck Depression Inventory, Fatigue Symptom Inventory, Cognitive Capacity Screening Examination, Medical Outcomes Survey Short Form-36, and the Quality of Life Scale.


Plasma NPY was elevated in CFS subjects, compared to controls (p=.000) and to GWI cases (p=.000).

Receiver operating characteristics (ROC) curve analyses indicated that the predictive ability of plasma NPY to distinguish CFS patients from healthy controls and from GWI was significantly better than chance alone.

In 42 patients with CFS, plasma NPY had significant correlations (<0.05) with perceived stress, depression, anger/hostility, confusion, negative thoughts, positive thoughts, general health, and cognitive status.

In each case the correlation (+ or -) was in the anticipated direction.

Conclusions: This study is the first in the CFS literature to report that plasma NPY is elevated compared to healthy controls and to a fatigued comparison group, GWI patients.

The significant correlations of NPY with stress, negative mood, general health, depression and cognitive function strongly suggest that this peptide be considered as a biomarker to distinguish subsets of CFS.

Source: Behavioral and Brain Functions, Dec 29, 2010;#6,p76. PMID, by Fletcher M, Rosenthal M, Antoni M, Ironson G, Zeng X, Barnes Z, Harvey J, Hurwitz B, Levis S, Broderick G, Klimas N. Department of Medicine, University of Miami Miller School of Medicine, Miami, Department of Psychology, University of Miami, Coral Gables, and Miami Veterans Administration Health Care Center, Miami, Florida, USA; Department of Medicine, University of Alberta, Canada.[Email:;;]

Post a Comment

Featured Products From the ProHealth Store
Mitochondria Ignite™ with NT Factor® Optimized Curcumin Longvida® Ultra EPA  - Fish Oil

Article Comments Post a Comment

Confidence level?
Posted by: IanH
Dec 30, 2010
What is the actual confidence limits of these results? "Plasma NPY was elevated in CFS subjects, compared to controls (p=.000) and to GWI cases (p=.000)."
Reply Reply

Posted by: Sandy10m
Jan 13, 2011
It is interesting to note that the researchers believe the GWI patients do not have CFS, yet CFS is one of their main symptom sets. I have been diagnosed with GWI and CFS, so I question whether they can make this assumption.
Reply Reply
Optimized Curcumin Longvida with Omega-3

Featured Products

FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get Energized with Malic Acid & Magnesium
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength

Natural Remedies

Top 3 Nutrients to Detox the Liver and Soothe Digestion Top 3 Nutrients to Detox the Liver and Soothe Digestion
Eating Fat is Good... Maybe... Could Be... Sometimes Eating Fat is Good... Maybe... Could Be... Sometimes
Supercharge Your Brain with Two Powerful Nutrients Supercharge Your Brain with Two Powerful Nutrients
Fatigue & Fibro Fog: Could You Have a B-12 Deficiency? Fatigue & Fibro Fog: Could You Have a B-12 Deficiency?
Could a B-12 Deficiency Be Causing Your Symptoms? Could a B-12 Deficiency Be Causing Your Symptoms?

ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
Credit Card Processing
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2018 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map