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Antibiotic provides continuing relief for many with irritable bowel syndrome without constipation – Cedars Sinai

  [ 16 votes ]   [ Discuss This Article ] • January 6, 2011

While the concept of bacteria playing a key role in this condition was controversial a decade ago, this research confirms that bacteria in the gut may trigger the symptoms.

A ground-breaking antibiotic therapy developed at Cedars-Sinai Medical Center is the first potential drug treatment to provide irritable bowel syndrome patients with long-lasting relief of their symptoms even after they stop taking the medication, according to a study published in Jan 6 by the New England Journal of Medicine. [“Refaximin Therapy for Patients with Irritable Bowel Syndrome without Constipation.”]

Unlike traditional therapies for irritable bowel syndrome, such as antidepressant and other medications that have benefits only while on the drug, patients in the study reported relief of their symptoms extended for weeks after completing treatment with rifaximin.

Rifaximin is a minimally absorbed antibiotic that stays in the gut, unlike other types of oral antibiotics which typically pass though the GI wall into the bloodstream.

Specifically, in two large Phase 3 trials about 40% of patients with diarrhea and bloating reported significant relief from bloating, less abdominal pain and improved stool consistency for up to 10 weeks.

While the concept of bacteria playing a key role in this condition was controversial when first unveiled a decade ago, this research confirms that overgrowth of certain bacteria triggers the symptoms of the chronic condition, affecting an estimated 30 million people in the United States.

These findings show that targeted antibiotics provide safe and effective long-lasting relief for this condition, said Mark Pimentel, MD, GI Motility Program director and principal investigator of the clinical trials at Cedars-Sinai.

“For years, the treatment options for IBS patients have been extremely limited,” Dr. Pimentel says.

“IBS often does not respond well to treatments currently available, such as dietary changes and fiber supplements alone. With this antibiotic treatment, the patients feel better, and they continue to feel better after stopping the drug. This means that we did something to strike at the cause of the disease.”

In two 600-plus patient double-blind trials, IBS patients with mild to moderate diarrhea and bloating were randomly assigned to take a 550 milligram dose of rifaximin or placebo three times daily for two weeks.

Study participants were then followed for 10 weeks more. About 40% of patients who took the drug reported they had significant relief from bloating, abdominal pain and loose or watery stools. Further, that relief was sustained for weeks after they stopped taking the antibiotic.

Doctors commonly categorize IBS patients with:

• A “constipation predominant” condition,

• A “diarrhea-predominant” condition,

• Or an alternating pattern of diarrhea and constipation.

In addition, patients often experience abdominal pain or cramps, excess gas or bloating, and visible abdominal distension.

Because the cause of the disease had been elusive, treatments for the disease historically have focused on relieving its symptoms with medications that either slow or speed up the digestive process.

Earlier research by Dr. Pimentel and colleagues documented a link between bloating, the most common symptom, and bacterial fermentation in the gut related to small intestine bacterial overgrowth, or SIBO.

Rifaximin is approved by the U.S. Food and Drug Administration to treat travelers’ diarrhea (specifically E. coli) and hepatic encephalopathy. [This is a worsening of brain function resulting from reduced liver function, thought to be "mediated to a large extent by ammonia" generated by bacteria in the colon.]

Besides Cedars-Sinai, other centers participating in the clinical trials included Beth Israel Deaconess Medical Center in Boston, University of Michigan Medical Center in Ann Arbor, University of North Carolina at Chapel Hill, and Connecticut Gastroenterology Institute in Bristol, Conn.

Note: Rifaximin is marketed by Salix Pharmaceuticals Inc. Salix also provided funding for the studies. Dr. Pimentel discovered the use of rifaximin for IBS, and Cedars-Sinai holds patent rights to this discovery and has licensed rights to the invention to Salix. Dr. Pimentel is a consultant to Salix, Inc, and serves on its scientific advisory board.

Source: Cedars-Sinai Medical Center (Los Angeles) news release, Jan 6, 2011

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