Objectives: To determine whether interstitial cystitis/painful bladder syndrome (IC/PBS) in women is associated with antecedent sexual and reproductive characteristics.
Methods: By multivariate analyses, 312 incident IC/PBS cases were compared with matched controls for antecedent sexual and reproductive characteristics, adjusted by demographics, previous surgery, and nonbladder syndromes (NBSs), such as chronic pelvic pain, irritable bowel syndrome, and panic disorder.
Results: IC/PBS was significantly associated with:
• Previous female hormone use,
• A history of fewer pregnancies (in premenopausal women),
• And antecedent nonbladder syndromess, especially when expressed by the number of such syndromes.
Conclusions: Three antecedents to IC/PBS were prominent.
• Female hormone use was consistent with a pharmacologic effect or as a marker of its indications.
• A history of fewer pregnancies among premenopausal, but not postmenopausal, women with IC/PBS was consistent with pregnancy postponing the occurrence of IC/PBS, a marker for decisions to avoid pregnancy, or a result of recruitment bias.
• Nonbladder syndromes, especially the total number experienced by the participant, had the strongest correlation with IC/PBS.
This finding suggests that knowledge of the pathogeneses of these nonbladder syndromes, many of which are functional somatic syndromes, might reveal that of IC/PBS.
Source: Urology, Jan 6, 2011. PMID: 21215994, by Warren JW, Clauw DJ, Wesselmann U, Langenberg PW, Howard FM, Morozov V. Department of Medicine, University of Maryland School of Medicine, Baltimore; Department of Epidemiology and Public Health, University of Maryland School of Medicine; Departments of Anesthesiology, Medicine, University of Michigan School of Medicine, Ann Arbor; Department of Anesthesiology, University of alabama School of Medicine, Birmingham; Departs of Obstetrics and Gynecology, University of Rochester School of Medicine, New York, USA.