ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

16 Tips from 16 Years Sick

Fibromyalgia Fare Fit for All Seasons

Tangerine Oil: A Citrusy Essential Oil With Well-Rounded Uses

New Study Shows Artificial Sweeteners Lead to Diabetes

Essential Oils — An Effective and Healthy Option to Treat Headaches

Antioxidant treatment could halt neurodegeneration in early Parkinson's

Higher vitamin D levels associated with less severe disease in NAFLD patients

How zinc helps fight esophageal cancer

Krill Oil: Make This Omega-3 Supplement Part of Your Health Regimen

Everything You Need to Know About Black Cohosh

 
Print Page
Email Article

Cancer research “suggests inflammation, EBV infection and other conditions leading to NF-kB activation may promote XMRV spread in man”

  [ 7 votes ]   [ Discuss This Article ]
www.ProHealth.com • January 30, 2011


Abstract: “NF-kappa B Activation Stimulates Transcription and Replication of Xenotropic Murine Leukemia Virus-Related Virus in Human B-lineage and Prostate Carcinoma Cells” – Source: Journal of Virology, Jan 26, 2011

Authors: S Sakakibara, et al., National Cancer Institute

Xenotropic murine leukemia virus-related virus (XMRV) is a gammaretrovirus linked to prostate carcinoma and chronic fatigue syndrome.

Here we report that NF-kappaB [NF-kB] activation can markedly increase XMRV production.

The inflammatory cytokine TNFalpha, which activates NF-?B, significantly augmented viral Gag protein production in XMRV-infected cells.

Reporter assays showed that TNFalpha and Epstein-Barr virus LMP1 (latent membrane protein 1), an intrinsic NF-kB activator, increased LTR-dependent XMRV transcription.

We identify two NF-?B binding sites (designated kB-1 and kB-2) in the long terminal repeat (LTR) U3 region of XMRV, and demonstrate that both sites bind to the NF-?B component p65/RelA.

Mutation of the kB-1 site, but not the kB-2 site, impaired responsiveness to TNFalpha and LMP1 in reporter assays.

A mutant XMRV at the kB-1 site replicated significantly less efficiently than the wild-type XMRV in the prostate carcinoma LNCaP, DU145 and PC3 cell lines, HEK293 cells, the EBV-immortalized cell line IB4 and the Burkitt's lymphoma cell line BJAB.

These results:

• Demonstrate that TNFalpha and EBV LMP1 enhance XMRV replication in prostate carcinoma and B-lineage cells through the kB-1 site in the XMRV LTR,

• Suggesting that inflammation, EBV infection and other conditions leading to NF-kB activation may promote XMRV spread in man.

Source: Journal of Virology, Jan 26, 2011. PMID: 21270144, by Sakakibara S, Sakakibara K, Tosato G. Laboratory of Cellular Oncology, and Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. [Email: sakakibs@mail.nih.gov]





Post a Comment

Featured Products From the ProHealth Store
Mitochondria Ignite™ with NT Factor® Ultra ATP+, Double Strength Vitamin D3 Extreme™


Article Comments



Be the first to comment on this article!

Post a Comment


 
Optimized Curcumin Longvida with Omega-3

Featured Products

Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health

Natural Remedies

Aching Muscles? Top 10 Nutrients to Take Back Your Life Aching Muscles? Top 10 Nutrients to Take Back Your Life
Inflammation Disrupts Memory - What Can You Do to Protect Your Brain? Inflammation Disrupts Memory - What Can You Do to Protect Your Brain?
Itching to Find Dry Skin Relief? Itching to Find Dry Skin Relief?
The Surprising Benefits of Probiotics - What You Didn't Know The Surprising Benefits of Probiotics - What You Didn't Know
How Glutathione Can Save Your Life How Glutathione Can Save Your Life

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map