ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Is Magnesium the Missing Link in Your Heart Healthy Routine?

A Little Zinc Goes a Long Way

Supplementation with vitamin D associated with improved testosterone, erectile function among middle...

More evidence for calorie restriction’s longevity effect

Vitamin D deficiency increases risk of chronic headache

Wearable biosensors can flag illness, Lyme disease, risk for diabetes; low airplane oxygen

VIDEO: The Best Brain Foods That Help Increase Your Memory!

Iron (And More) For Lasting, Natural Energy

Get the Most From Your Green Tea

Affordable Care Act made cancer screening more accessible for millions, study finds

 
Print Page
Email Article

New Curcumin Compound May Protect, Rebuild Brain Cells After Stroke – Cedars-Sinai; Salk Institute

  [ 19 votes ]   [ Discuss This Article ]
www.ProHealth.com • February 11, 2011


Animal trials have demonstrated the compound's ability to cross the blood-brain barrier and play a role in cell & neuron support & repair.

Whether or not you’re fond of Indian, Southeast Asian and Middle Eastern food, stroke researchers at Cedars-Sinai Medical Center think you may become a fan of one of their key spices.

The scientists created a new molecule from curcumin, a chemical component of the golden-colored spice turmeric, and found in laboratory experiments that it affects mechanisms that protect and help regenerate brain cells after stroke. Research scientist Paul A. Lapchak, PhD, director of Translational Research in the Department of Neurology at Cedars-Sinai Medical Center, presented these findings(1) Feb 9 at the American Heart Association International Stroke Conference in Los Angeles.

Only one drug is now approved for ischemic stroke, which occurs when a clot blocks blood flow to the brain. Commonly called a “clot-busting drug,” tissue plasminogen activator (tPA) is injected intravenously to dissolve clots and reinstate blood flow. If blood and oxygen are restored in time, consequences of the stroke, such as speech, memory, movement and other impairments, may be reduced.

The new curcumin-hybrid compound - CNB-001 - does not attack clots but instead repairs stroke damage at the molecular level that feed and support the all-important brain cells, neurons.

Curcumin has been studied for its potential to treat brain injury and disease, and while the substance itself looks promising, it has several drawbacks, especially as an emergency stroke treatment, which must be quick to be effective: It is not well absorbed in the body, fails to reach its target in high concentrations, becomes depleted quickly, and is blocked from entering the brain by a natural protective mechanism called the blood-brain barrier.

“CNB-001 has many of the same benefits of curcumin but appears to be a better choice of compound for acute stroke,” says Lapchak, “because it:

• Crosses the blood-brain barrier,

• Is quickly distributed in the brain,

• And moderates several critical mechanisms involved in neuronal survival.”

Lapchak adds that he and his colleagues expect the new drug to move to human clinical trials soon.

When brain tissue is deprived of blood and oxygen, a cascading series of interrelated events triggers at the molecular level, breaking down the normal electrical and chemical “signaling pathways” responsible for nourishing and supporting neurons. The environment quickly becomes toxic, killing brain cells and destroying their support structures.

Theoretically, interrupting these harmful events and restoring normal pathway function could prevent cell death and the memory and behavioral deficits that result, but it will take a cocktail of drugs or a drug capable of targeting many mechanisms to correct the many pathways damaged by stroke, Lapchak says.

CNB-001 protects brain cells from damage by repairing four major pathways. One mechanism also plays a major role in the growth and survival of neurons.

The drug reduced stroke-caused “motor deficits” - problems of muscle and movement control - in this laboratory study. It was effective when administered up to an hour after stroke, which correlates with about three hours in humans, the same time frame for which tPA is currently approved.

Lapchak and colleagues at the Salk Institute for Biological Studies used the same laboratory rabbit model to mimic human stroke that earlier researchers had employed before the clot-busting drug tPA entered clinical trials.

Patrick D. Lyden, MD, chairman of Cedars-Sinai’s Department of Neurology, helped lead a major trial that resulted in the Food and Drug Administration’s 1996 approval of tPA, still considered the stroke treatment gold standard.

Those who cook Indian, Thai, Malay and Persian dishes know turmeric well for its zesty flavor used in curries, and for the rich color it imparts to food. Turmeric also has a long history of use in Ayurvedic and Chinese traditional medicine.

Grants from the National Institute of Neurological Disorders and Stroke, part of the National Institutes of Health, supported the CNB-001 study (NS060685 to PAL).

[Ed Note: for more information on why curcumin has been a staple of Ayervedic medicine for more than 4,000 years, and on emerging research to discover the reasons for its benefits, see "Curcumin - a Golden Gift of Nature with Benefits Still Untold."]

_____

1. Abstracts of newly-published articles on this research include:

Expert Opinion on Investigational Drugs, Jan 2011: “Neuroprotective and neurotrophic curcuminoids to treat stroke: A translational Perspective,” a review of data published 2002-2010 by Paul A Lapchak, PhD, Cedars-Sinai Medical Center, Department of Neurology, Los Angeles, California, USA. [Email: Paul.Lapchak@cshs.org]

Journal of Neurochemistry, Jan 2011: “Delayed treatment with a novel neurotrophic compound reduces behavioral deficits in rabbit ischemic stroke,” Paul A Lapchak, David R Schubert, Pamela A Maher. Cedars Sinai Medical Center, Los Angeles, The Salk Institute, Cellular Neurobiology Laboratories, La Jolla, California, USA. [Email: Schubert@salk.edu]

2.  Abstracts of the four Stroke Conference poster presentations on this research can be found in a PDF file, pages 39-42 (http://stroke.ahajournals.org/cgi/reprint/STR.0b013e3182074d9b)

Source: Cedars-Sinai Medical Center news release Feb 9, 2011; and 2011 International Stroke conference and Nursing Symposium Poster Presentation Abstracts.




Post a Comment

Featured Products From the ProHealth Store
Curcumin, Longvida™ Ultra EPA  - Fish Oil Energy NADH™ 12.5mg

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Curcumin, Longvida™ Curcumin, Longvida™
Helps Support Cognition, Memory & Overall Health
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Curcumin 95 (Tumeric) Curcumin 95 (Tumeric)
Natural Relief for Aching Joints & Digestive Upset

Natural Remedies

Sunshine Vitamin Has D-lightful Health Benefits Sunshine Vitamin Has D-lightful Health Benefits
Research Links Green Tea to Weight Loss Research Links Green Tea to Weight Loss
Mitochondria-Booster NIAGEN® Shows Promise in First Human Clinical Trial Mitochondria-Booster NIAGEN® Shows Promise in First Human Clinical Trial
Coping When Colds or Flu Catch Up with You Coping When Colds or Flu Catch Up with You
Astaxanthin - A Little-Known but Power-Packed Nutrient Astaxanthin - A Little-Known but Power-Packed Nutrient

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map